Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics.
Objectives Exposure to persistent organohalogen pollutants was suggested to impair male reproductive function. A gene-environment interaction has been proposed. No genes modifying the effect of persistent organohalogen pollutants on reproductive organs have yet been identified. We aimed to investiga...
Published in: | Pharmacogenetics and Genomics |
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Main Authors: | , , , , , , , , , , , , , , , , |
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Hagerstown
2007
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Online Access: | http://hdl.handle.net/11380/584934 https://doi.org/10.1097/01.fpc.0000236329.26551.78 |
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ftunivmodena:oai:iris.unimore.it:11380/584934 2024-04-21T08:03:58+00:00 Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. GIWERCMAN A RYLANDER L RIGNELL HYDBOM A JONSSON BA PEDERSEN HS LUDWICKI JK LESOVOY V ZVYEZDAY V SPANO M BIZZARO D BONEFELD JORGENSEN EC TOFT G BONDE JP GIWERCMAN C TIIDO T GIWERCMAN YL MANICARDI, Gian Carlo Giwercman, A Rylander, L RIGNELL HYDBOM, A Jonsson, Ba Pedersen, H Ludwicki, Jk Lesovoy, V Zvyezday, V Spano, M Manicardi, Gian Carlo Bizzaro, D BONEFELD JORGENSEN, Ec Toft, G Bonde, Jp Giwercman, C Tiido, T Giwercman, Yl 2007 STAMPA http://hdl.handle.net/11380/584934 https://doi.org/10.1097/01.fpc.0000236329.26551.78 eng eng Hagerstown London : Lippincott Williams & Wilkins, 2005- country:PHILADELPHIA info:eu-repo/semantics/altIdentifier/pmid/17502831 info:eu-repo/semantics/altIdentifier/wos/WOS:000246931900002 volume:17 issue:6 firstpage:391 lastpage:401 journal:PHARMACOGENETICS AND GENOMICS http://hdl.handle.net/11380/584934 doi:10.1097/01.fpc.0000236329.26551.78 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33847668918 androgen-receptor CAG-repeat gene-environment-interaction persistent-organohalogen-pollutant semen-quality info:eu-repo/semantics/article 2007 ftunivmodena https://doi.org/10.1097/01.fpc.0000236329.26551.78 2024-03-28T01:24:40Z Objectives Exposure to persistent organohalogen pollutants was suggested to impair male reproductive function. A gene-environment interaction has been proposed. No genes modifying the effect of persistent organohalogen pollutants on reproductive organs have yet been identified. We aimed to investigate whether the CAG and GGN polymorphisms in the androgen receptor gene modify the effect of persistent organohalogen pollutant exposure on human sperm characteristics. Methods Semen and blood from 680 men [mean (SD) age 34 (10) years] from Greenland, Sweden, Warsaw (Poland) and Kharkiv (Ukraine) were collected. Persistent organohalogen pollutant exposure was assessed by measuring serum levels of 2,2,4,4,5,5'-hexachlorobiphenyl (CB-153) and dichlorodiphenyl dichloroethene (p,p'-DDE). Semen characteristics (volume, sperm concentration, total count proportion of progressively motile and morphology) and DNA fragmentation index (DFI) were determined. CAG and GGN repeat lengths were determined by direct sequencing of leukocyte DNA. Results A statistically significant interaction was found between the CB-153 group and CAG repeat category in relation to sperm concentration and total sperm count (P=0.03 and 0.01, respectively). For p,p'-DDE, in the European cohorts a significant interaction was found in relation to DFI (P=0.01). For CAG<20, sperm concentration and total sperm count were 35 and 42% lower, respectively, when the group with CB-153 exposure above median was compared with that below the median. DF1 was 40% higher in the high p,p'-DDE exposure group for CAG < 21. Conclusions This study indicated that the androgen receptor CAG repeat length might modify the susceptibility of an individual to the adverse effects of persistent organohalogen pollutant exposure on semen quality. Other studies regarding this matter are warranted. Article in Journal/Newspaper Greenland Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) Pharmacogenetics and Genomics 17 6 391 401 |
institution |
Open Polar |
collection |
Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
op_collection_id |
ftunivmodena |
language |
English |
topic |
androgen-receptor CAG-repeat gene-environment-interaction persistent-organohalogen-pollutant semen-quality |
spellingShingle |
androgen-receptor CAG-repeat gene-environment-interaction persistent-organohalogen-pollutant semen-quality GIWERCMAN A RYLANDER L RIGNELL HYDBOM A JONSSON BA PEDERSEN HS LUDWICKI JK LESOVOY V ZVYEZDAY V SPANO M BIZZARO D BONEFELD JORGENSEN EC TOFT G BONDE JP GIWERCMAN C TIIDO T GIWERCMAN YL MANICARDI, Gian Carlo Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. |
topic_facet |
androgen-receptor CAG-repeat gene-environment-interaction persistent-organohalogen-pollutant semen-quality |
description |
Objectives Exposure to persistent organohalogen pollutants was suggested to impair male reproductive function. A gene-environment interaction has been proposed. No genes modifying the effect of persistent organohalogen pollutants on reproductive organs have yet been identified. We aimed to investigate whether the CAG and GGN polymorphisms in the androgen receptor gene modify the effect of persistent organohalogen pollutant exposure on human sperm characteristics. Methods Semen and blood from 680 men [mean (SD) age 34 (10) years] from Greenland, Sweden, Warsaw (Poland) and Kharkiv (Ukraine) were collected. Persistent organohalogen pollutant exposure was assessed by measuring serum levels of 2,2,4,4,5,5'-hexachlorobiphenyl (CB-153) and dichlorodiphenyl dichloroethene (p,p'-DDE). Semen characteristics (volume, sperm concentration, total count proportion of progressively motile and morphology) and DNA fragmentation index (DFI) were determined. CAG and GGN repeat lengths were determined by direct sequencing of leukocyte DNA. Results A statistically significant interaction was found between the CB-153 group and CAG repeat category in relation to sperm concentration and total sperm count (P=0.03 and 0.01, respectively). For p,p'-DDE, in the European cohorts a significant interaction was found in relation to DFI (P=0.01). For CAG<20, sperm concentration and total sperm count were 35 and 42% lower, respectively, when the group with CB-153 exposure above median was compared with that below the median. DF1 was 40% higher in the high p,p'-DDE exposure group for CAG < 21. Conclusions This study indicated that the androgen receptor CAG repeat length might modify the susceptibility of an individual to the adverse effects of persistent organohalogen pollutant exposure on semen quality. Other studies regarding this matter are warranted. |
author2 |
Giwercman, A Rylander, L RIGNELL HYDBOM, A Jonsson, Ba Pedersen, H Ludwicki, Jk Lesovoy, V Zvyezday, V Spano, M Manicardi, Gian Carlo Bizzaro, D BONEFELD JORGENSEN, Ec Toft, G Bonde, Jp Giwercman, C Tiido, T Giwercman, Yl |
format |
Article in Journal/Newspaper |
author |
GIWERCMAN A RYLANDER L RIGNELL HYDBOM A JONSSON BA PEDERSEN HS LUDWICKI JK LESOVOY V ZVYEZDAY V SPANO M BIZZARO D BONEFELD JORGENSEN EC TOFT G BONDE JP GIWERCMAN C TIIDO T GIWERCMAN YL MANICARDI, Gian Carlo |
author_facet |
GIWERCMAN A RYLANDER L RIGNELL HYDBOM A JONSSON BA PEDERSEN HS LUDWICKI JK LESOVOY V ZVYEZDAY V SPANO M BIZZARO D BONEFELD JORGENSEN EC TOFT G BONDE JP GIWERCMAN C TIIDO T GIWERCMAN YL MANICARDI, Gian Carlo |
author_sort |
GIWERCMAN A |
title |
Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. |
title_short |
Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. |
title_full |
Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. |
title_fullStr |
Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. |
title_full_unstemmed |
Androgen receptor gene CAG repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. |
title_sort |
androgen receptor gene cag repeat length as a modifier of the association between persistent organohalogen pollutant exposure markers and semen characteristics. |
publisher |
Hagerstown |
publishDate |
2007 |
url |
http://hdl.handle.net/11380/584934 https://doi.org/10.1097/01.fpc.0000236329.26551.78 |
genre |
Greenland |
genre_facet |
Greenland |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/17502831 info:eu-repo/semantics/altIdentifier/wos/WOS:000246931900002 volume:17 issue:6 firstpage:391 lastpage:401 journal:PHARMACOGENETICS AND GENOMICS http://hdl.handle.net/11380/584934 doi:10.1097/01.fpc.0000236329.26551.78 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33847668918 |
op_doi |
https://doi.org/10.1097/01.fpc.0000236329.26551.78 |
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Pharmacogenetics and Genomics |
container_volume |
17 |
container_issue |
6 |
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