Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: A cross-sectional study
BACKGROUND: Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited. METHODS: Fertility was examined in four regions with contrasting blood levels of POPs. Pregnant women and their partners in Warsaw (Poland), Kharkiv (Ukrain...
Published in: | Environmental Health |
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Format: | Article in Journal/Newspaper |
Language: | English |
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London : BioMed Central, [2002-
2005
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Online Access: | http://hdl.handle.net/11380/455197 https://doi.org/10.1186/1476-069X-4-26 |
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ftunivmodena:oai:iris.unimore.it:11380/455197 2024-02-11T10:04:26+01:00 Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: A cross-sectional study GUNNAR TOFT ANNA AXMON ALEKSANDER GIWERCMAN ANE MARIE THULSTRUP ANNA RIGNELL HYDBOM HENNING SLOTH PEDERSEN JAN K. LUDWICKI VALENTINA ZVYEZDAY ANDERY ZINCHUK MARCELLO SPANO MANICARDI, Gian Carlo EVA C. BONEFELD JRGENSEN LARS HAGMAR JENS PETER BONDE AND INUENDO Gunnar, Toft Anna, Axmon Aleksander, Giwercman ANE MARIE, Thulstrup ANNA RIGNELL, Hydbom HENNING SLOTH, Pedersen JAN K., Ludwicki Valentina, Zvyezday Andery, Zinchuk Marcello, Spano Manicardi, Gian Carlo EVA C., BONEFELD JRGENSEN Lars, Hagmar JENS PETER BONDE AND, Inuendo 2005 ELETTRONICO http://hdl.handle.net/11380/455197 https://doi.org/10.1186/1476-069X-4-26 eng eng London : BioMed Central, [2002- info:eu-repo/semantics/altIdentifier/pmid/16280075 volume:4 firstpage:1 lastpage:26 numberofpages:26 journal:ENVIRONMENTAL HEALTH http://hdl.handle.net/11380/455197 doi:10.1186/1476-069X-4-26 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-28844489678 info:eu-repo/semantics/openAccess Persistent organochlorine pollutant reproduction serum levels of POPs info:eu-repo/semantics/article 2005 ftunivmodena https://doi.org/10.1186/1476-069X-4-26 2024-01-23T23:13:13Z BACKGROUND: Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited. METHODS: Fertility was examined in four regions with contrasting blood levels of POPs. Pregnant women and their partners in Warsaw (Poland), Kharkiv (Ukraine) and Greenland were consecutively enrolled during antenatal visits. Swedish fishermen and their spouses were recruited separately and independently of current pregnancy. Lipid adjusted serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (DDE) were available for both partners. Time to pregnancy interviews were obtained among 2269 women and 798 men provided a semen sample. RESULTS: Inuits had high levels of both POP markers, Swedish fishermen were high in CB-153 but low in DDE, men from Kharkiv were high in DDE and low in CB-153 while men from Warsaw were low in CB-153 and had intermediate DDE levels. Compared to Warsaw couples, fecundability was reduced among couples from Kharkiv [adjusted fecundability ratio (FR) 0.64 (95% CI 0.5-0.8)] and elevated in Swedish fishermen families [FR 1.26 (95% CI 1.0-1.6)]. Adjusted geometric means of sperm counts and morphology did not differ between regions while sperm motility was higher in men living in Warsaw. CONCLUSION: We observed regional differences in time to pregnancy and sperm motility that may be related to regional differences in POP blood levels, but other interpretations are also plausible. In particular, differences in access to safe contraception and in the prevalence of contraceptive failures are most likely to bias comparisons of time to pregnancy. Article in Journal/Newspaper Greenland inuits Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) Greenland Environmental Health 4 1 |
institution |
Open Polar |
collection |
Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
op_collection_id |
ftunivmodena |
language |
English |
topic |
Persistent organochlorine pollutant reproduction serum levels of POPs |
spellingShingle |
Persistent organochlorine pollutant reproduction serum levels of POPs GUNNAR TOFT ANNA AXMON ALEKSANDER GIWERCMAN ANE MARIE THULSTRUP ANNA RIGNELL HYDBOM HENNING SLOTH PEDERSEN JAN K. LUDWICKI VALENTINA ZVYEZDAY ANDERY ZINCHUK MARCELLO SPANO MANICARDI, Gian Carlo EVA C. BONEFELD JRGENSEN LARS HAGMAR JENS PETER BONDE AND INUENDO Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: A cross-sectional study |
topic_facet |
Persistent organochlorine pollutant reproduction serum levels of POPs |
description |
BACKGROUND: Persistent organochlorine pollutants (POPs) may interfere with reproductive function but direct evidence in humans is very limited. METHODS: Fertility was examined in four regions with contrasting blood levels of POPs. Pregnant women and their partners in Warsaw (Poland), Kharkiv (Ukraine) and Greenland were consecutively enrolled during antenatal visits. Swedish fishermen and their spouses were recruited separately and independently of current pregnancy. Lipid adjusted serum concentrations of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (DDE) were available for both partners. Time to pregnancy interviews were obtained among 2269 women and 798 men provided a semen sample. RESULTS: Inuits had high levels of both POP markers, Swedish fishermen were high in CB-153 but low in DDE, men from Kharkiv were high in DDE and low in CB-153 while men from Warsaw were low in CB-153 and had intermediate DDE levels. Compared to Warsaw couples, fecundability was reduced among couples from Kharkiv [adjusted fecundability ratio (FR) 0.64 (95% CI 0.5-0.8)] and elevated in Swedish fishermen families [FR 1.26 (95% CI 1.0-1.6)]. Adjusted geometric means of sperm counts and morphology did not differ between regions while sperm motility was higher in men living in Warsaw. CONCLUSION: We observed regional differences in time to pregnancy and sperm motility that may be related to regional differences in POP blood levels, but other interpretations are also plausible. In particular, differences in access to safe contraception and in the prevalence of contraceptive failures are most likely to bias comparisons of time to pregnancy. |
author2 |
Gunnar, Toft Anna, Axmon Aleksander, Giwercman ANE MARIE, Thulstrup ANNA RIGNELL, Hydbom HENNING SLOTH, Pedersen JAN K., Ludwicki Valentina, Zvyezday Andery, Zinchuk Marcello, Spano Manicardi, Gian Carlo EVA C., BONEFELD JRGENSEN Lars, Hagmar JENS PETER BONDE AND, Inuendo |
format |
Article in Journal/Newspaper |
author |
GUNNAR TOFT ANNA AXMON ALEKSANDER GIWERCMAN ANE MARIE THULSTRUP ANNA RIGNELL HYDBOM HENNING SLOTH PEDERSEN JAN K. LUDWICKI VALENTINA ZVYEZDAY ANDERY ZINCHUK MARCELLO SPANO MANICARDI, Gian Carlo EVA C. BONEFELD JRGENSEN LARS HAGMAR JENS PETER BONDE AND INUENDO |
author_facet |
GUNNAR TOFT ANNA AXMON ALEKSANDER GIWERCMAN ANE MARIE THULSTRUP ANNA RIGNELL HYDBOM HENNING SLOTH PEDERSEN JAN K. LUDWICKI VALENTINA ZVYEZDAY ANDERY ZINCHUK MARCELLO SPANO MANICARDI, Gian Carlo EVA C. BONEFELD JRGENSEN LARS HAGMAR JENS PETER BONDE AND INUENDO |
author_sort |
GUNNAR TOFT |
title |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: A cross-sectional study |
title_short |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: A cross-sectional study |
title_full |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: A cross-sectional study |
title_fullStr |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: A cross-sectional study |
title_full_unstemmed |
Fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: A cross-sectional study |
title_sort |
fertility in four regions spanning large contrasts in serum levels of widespread persistent organochlorines: a cross-sectional study |
publisher |
London : BioMed Central, [2002- |
publishDate |
2005 |
url |
http://hdl.handle.net/11380/455197 https://doi.org/10.1186/1476-069X-4-26 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland inuits |
genre_facet |
Greenland inuits |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/16280075 volume:4 firstpage:1 lastpage:26 numberofpages:26 journal:ENVIRONMENTAL HEALTH http://hdl.handle.net/11380/455197 doi:10.1186/1476-069X-4-26 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-28844489678 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/1476-069X-4-26 |
container_title |
Environmental Health |
container_volume |
4 |
container_issue |
1 |
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1790601031268171776 |