Semen quality and exposure to persistent organochlorine pollutants
Background: Inconsistent results have been found in previous human studies on male reproductive toxicity of persistent organochlorine pollutants. The majority of studies have been conducted among selected populations of infertility clients or among occupational cohorts including a limited number of...
Published in: | Epidemiology |
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2006
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Online Access: | http://hdl.handle.net/11380/304021 https://doi.org/10.1097/01.ede.0000221769.41028.d2 |
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ftunivmodena:oai:iris.unimore.it:11380/304021 2024-04-14T08:12:26+00:00 Semen quality and exposure to persistent organochlorine pollutants G. Toft A. Rignell Hydbom E. Tyrkiel M. Shvets A. Giwercman CH Lindh HS Pedersen JK Ludwicki K. Lesovoy L. Hagmar M. Spano EC Bonefeld Jorgensen AM Thulstrup JP Bonde MANICARDI, Gian Carlo G., Toft A., Rignell Hydbom E., Tyrkiel M., Shvet A., Giwercman Ch, Lindh Hs, Pedersen Jk, Ludwicki K., Lesovoy L., Hagmar M., Spano Manicardi, Gian Carlo EC Bonefeld, Jorgensen Am, Thulstrup Jp, Bonde 2006 STAMPA http://hdl.handle.net/11380/304021 https://doi.org/10.1097/01.ede.0000221769.41028.d2 eng eng info:eu-repo/semantics/altIdentifier/pmid/16755259 info:eu-repo/semantics/altIdentifier/wos/WOS:000238740600016 volume:17 issue:4 firstpage:450 lastpage:458 journal:EPIDEMIOLOGY http://hdl.handle.net/11380/304021 doi:10.1097/01.ede.0000221769.41028.d2 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33748114135 MALE REPRODUCTIVE FUNCTION VECTOR-CONTROL WORKERS POLYCHLORINATED-BIPHENYLS SPERM FUNCTION POSTNATAL EXPOSURE LIMPOPO PROVINCE HORMONE-LEVELS DDT EXPOSURE SOUTH-AFRICA ADULT RATS info:eu-repo/semantics/article 2006 ftunivmodena https://doi.org/10.1097/01.ede.0000221769.41028.d2 2024-03-21T17:36:31Z Background: Inconsistent results have been found in previous human studies on male reproductive toxicity of persistent organochlorine pollutants. The majority of studies have been conducted among selected populations of infertility clients or among occupational cohorts including a limited number of participants. Methods: We conducted a cross-sectional study of semen quality and serum concentration of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) among 763 men. We included men from all regions in Greenland (n = 194), fishermen from Sweden (n = 185), inhabitants of the city of Kharkiv, Ukraine (n = 195), and inhabitants of the city of Warsaw, Poland (n = 189). Blood samples were analyzed for CB-153 and p,p'-DDE using gas chromatography-mass spectrometry and adjusted for serum lipids. Results: Sperm concentration was not impaired with increasing serum CB-153 or p,p'-DDE levels in any of the separate groups or overall. Similarly, the proportion of morphologically normal sperm was not associated with either CB-153 or p,p'-DDE blood concentration. However, sperm motility was inversely related to CB-153 concentration in Greenland and the Swedish fishermen population. Across all 4 regions, the sperm motility decreased on average by 3.6% (95% confidence interval = 1.7% to 5.6%) per one-unit increase in the log of blood CB-153 (ng/g lipid). The concentration of p,p'-DDE was negatively associated with sperm motility in the Greenlandic population and in the compiled dataset. Conclusion: Adult exposure to persistent organochlorine pollutants within the ranges observed in the present study is not likely to cause reduction in sperm concentration or morphology. However, higher exposure may be associated with impaired sperm motility. Article in Journal/Newspaper Greenland greenlandic Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) Greenland Epidemiology 17 4 450 458 |
institution |
Open Polar |
collection |
Archivio della ricerca dell'Università di Modena e Reggio Emilia (Unimore: IRIS) |
op_collection_id |
ftunivmodena |
language |
English |
topic |
MALE REPRODUCTIVE FUNCTION VECTOR-CONTROL WORKERS POLYCHLORINATED-BIPHENYLS SPERM FUNCTION POSTNATAL EXPOSURE LIMPOPO PROVINCE HORMONE-LEVELS DDT EXPOSURE SOUTH-AFRICA ADULT RATS |
spellingShingle |
MALE REPRODUCTIVE FUNCTION VECTOR-CONTROL WORKERS POLYCHLORINATED-BIPHENYLS SPERM FUNCTION POSTNATAL EXPOSURE LIMPOPO PROVINCE HORMONE-LEVELS DDT EXPOSURE SOUTH-AFRICA ADULT RATS G. Toft A. Rignell Hydbom E. Tyrkiel M. Shvets A. Giwercman CH Lindh HS Pedersen JK Ludwicki K. Lesovoy L. Hagmar M. Spano EC Bonefeld Jorgensen AM Thulstrup JP Bonde MANICARDI, Gian Carlo Semen quality and exposure to persistent organochlorine pollutants |
topic_facet |
MALE REPRODUCTIVE FUNCTION VECTOR-CONTROL WORKERS POLYCHLORINATED-BIPHENYLS SPERM FUNCTION POSTNATAL EXPOSURE LIMPOPO PROVINCE HORMONE-LEVELS DDT EXPOSURE SOUTH-AFRICA ADULT RATS |
description |
Background: Inconsistent results have been found in previous human studies on male reproductive toxicity of persistent organochlorine pollutants. The majority of studies have been conducted among selected populations of infertility clients or among occupational cohorts including a limited number of participants. Methods: We conducted a cross-sectional study of semen quality and serum concentration of 2,2',4,4',5,5'-hexachlorobiphenyl (CB-153) and 1,1-dichloro-2,2-bis (p-chlorophenyl)-ethylene (p,p'-DDE) among 763 men. We included men from all regions in Greenland (n = 194), fishermen from Sweden (n = 185), inhabitants of the city of Kharkiv, Ukraine (n = 195), and inhabitants of the city of Warsaw, Poland (n = 189). Blood samples were analyzed for CB-153 and p,p'-DDE using gas chromatography-mass spectrometry and adjusted for serum lipids. Results: Sperm concentration was not impaired with increasing serum CB-153 or p,p'-DDE levels in any of the separate groups or overall. Similarly, the proportion of morphologically normal sperm was not associated with either CB-153 or p,p'-DDE blood concentration. However, sperm motility was inversely related to CB-153 concentration in Greenland and the Swedish fishermen population. Across all 4 regions, the sperm motility decreased on average by 3.6% (95% confidence interval = 1.7% to 5.6%) per one-unit increase in the log of blood CB-153 (ng/g lipid). The concentration of p,p'-DDE was negatively associated with sperm motility in the Greenlandic population and in the compiled dataset. Conclusion: Adult exposure to persistent organochlorine pollutants within the ranges observed in the present study is not likely to cause reduction in sperm concentration or morphology. However, higher exposure may be associated with impaired sperm motility. |
author2 |
G., Toft A., Rignell Hydbom E., Tyrkiel M., Shvet A., Giwercman Ch, Lindh Hs, Pedersen Jk, Ludwicki K., Lesovoy L., Hagmar M., Spano Manicardi, Gian Carlo EC Bonefeld, Jorgensen Am, Thulstrup Jp, Bonde |
format |
Article in Journal/Newspaper |
author |
G. Toft A. Rignell Hydbom E. Tyrkiel M. Shvets A. Giwercman CH Lindh HS Pedersen JK Ludwicki K. Lesovoy L. Hagmar M. Spano EC Bonefeld Jorgensen AM Thulstrup JP Bonde MANICARDI, Gian Carlo |
author_facet |
G. Toft A. Rignell Hydbom E. Tyrkiel M. Shvets A. Giwercman CH Lindh HS Pedersen JK Ludwicki K. Lesovoy L. Hagmar M. Spano EC Bonefeld Jorgensen AM Thulstrup JP Bonde MANICARDI, Gian Carlo |
author_sort |
G. Toft |
title |
Semen quality and exposure to persistent organochlorine pollutants |
title_short |
Semen quality and exposure to persistent organochlorine pollutants |
title_full |
Semen quality and exposure to persistent organochlorine pollutants |
title_fullStr |
Semen quality and exposure to persistent organochlorine pollutants |
title_full_unstemmed |
Semen quality and exposure to persistent organochlorine pollutants |
title_sort |
semen quality and exposure to persistent organochlorine pollutants |
publishDate |
2006 |
url |
http://hdl.handle.net/11380/304021 https://doi.org/10.1097/01.ede.0000221769.41028.d2 |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
Greenland greenlandic |
genre_facet |
Greenland greenlandic |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/16755259 info:eu-repo/semantics/altIdentifier/wos/WOS:000238740600016 volume:17 issue:4 firstpage:450 lastpage:458 journal:EPIDEMIOLOGY http://hdl.handle.net/11380/304021 doi:10.1097/01.ede.0000221769.41028.d2 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33748114135 |
op_doi |
https://doi.org/10.1097/01.ede.0000221769.41028.d2 |
container_title |
Epidemiology |
container_volume |
17 |
container_issue |
4 |
container_start_page |
450 |
op_container_end_page |
458 |
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1796310233380814848 |