Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color
Red coloration of muscle tissue (flesh) is a unique trait in several salmonid genera, including Atlantic salmon. The color results from dietary carotenoids deposited in the flesh, whereas the color intensity is affected both by diet and genetic components. Herein we report on a genome-wide associati...
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Online Access: | https://hdl.handle.net/11250/2680141 https://doi.org/10.1038/s41598-019-56438-3 |
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ftunivmob:oai:nmbu.brage.unit.no:11250/2680141 2024-09-15T17:56:25+00:00 Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color Helgeland, Hanna Sodeland, Marte Zoric, Nina Torgersen, Jacob Seilø Grammes, Fabian Moen, Thomas Kjøglum, Sissel Lien, Sigbjørn Våge, Dag Inge 2020-01-17T09:40:07Z application/pdf https://hdl.handle.net/11250/2680141 https://doi.org/10.1038/s41598-019-56438-3 eng eng Universitetet i Agder: UiA-CCR urn:issn:2045-2322 https://hdl.handle.net/11250/2680141 https://doi.org/10.1038/s41598-019-56438-3 cristin:1775438 Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no Scientific Reports Peer reviewed Journal article 2020 ftunivmob https://doi.org/10.1038/s41598-019-56438-3 2024-07-19T03:05:57Z Red coloration of muscle tissue (flesh) is a unique trait in several salmonid genera, including Atlantic salmon. The color results from dietary carotenoids deposited in the flesh, whereas the color intensity is affected both by diet and genetic components. Herein we report on a genome-wide association study (GWAS) to identify genetic variation underlying this trait. Two SNPs on ssa26 showed strong associations to the flesh color in salmon. Two genes known to be involved in carotenoid metabolism were located in this QTL- region: beta-carotene oxygenase 1 (bco1) and beta-carotene oxygenase 1 like (bco1l). To determine whether flesh color variation is caused by one, or both, of these genes, functional studies were carried out including mRNA and protein expression in fish with red and pale flesh color. The catalytic abilities of these two genes were also tested with different carotenoids. Our results suggest bco1l to be the most likely gene to explain the flesh color variation observed in this population. publishedVersion Article in Journal/Newspaper Atlantic salmon Open archive Norwegian University of Life Sciences: Brage NMBU Scientific Reports 9 1 |
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Open Polar |
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Open archive Norwegian University of Life Sciences: Brage NMBU |
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ftunivmob |
language |
English |
description |
Red coloration of muscle tissue (flesh) is a unique trait in several salmonid genera, including Atlantic salmon. The color results from dietary carotenoids deposited in the flesh, whereas the color intensity is affected both by diet and genetic components. Herein we report on a genome-wide association study (GWAS) to identify genetic variation underlying this trait. Two SNPs on ssa26 showed strong associations to the flesh color in salmon. Two genes known to be involved in carotenoid metabolism were located in this QTL- region: beta-carotene oxygenase 1 (bco1) and beta-carotene oxygenase 1 like (bco1l). To determine whether flesh color variation is caused by one, or both, of these genes, functional studies were carried out including mRNA and protein expression in fish with red and pale flesh color. The catalytic abilities of these two genes were also tested with different carotenoids. Our results suggest bco1l to be the most likely gene to explain the flesh color variation observed in this population. publishedVersion |
format |
Article in Journal/Newspaper |
author |
Helgeland, Hanna Sodeland, Marte Zoric, Nina Torgersen, Jacob Seilø Grammes, Fabian Moen, Thomas Kjøglum, Sissel Lien, Sigbjørn Våge, Dag Inge |
spellingShingle |
Helgeland, Hanna Sodeland, Marte Zoric, Nina Torgersen, Jacob Seilø Grammes, Fabian Moen, Thomas Kjøglum, Sissel Lien, Sigbjørn Våge, Dag Inge Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
author_facet |
Helgeland, Hanna Sodeland, Marte Zoric, Nina Torgersen, Jacob Seilø Grammes, Fabian Moen, Thomas Kjøglum, Sissel Lien, Sigbjørn Våge, Dag Inge |
author_sort |
Helgeland, Hanna |
title |
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
title_short |
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
title_full |
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
title_fullStr |
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
title_full_unstemmed |
Genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
title_sort |
genomic and functional gene studies suggest a key role of beta-carotene oxygenase 1 like (bco1l) gene in salmon flesh color |
publishDate |
2020 |
url |
https://hdl.handle.net/11250/2680141 https://doi.org/10.1038/s41598-019-56438-3 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
Scientific Reports |
op_relation |
Universitetet i Agder: UiA-CCR urn:issn:2045-2322 https://hdl.handle.net/11250/2680141 https://doi.org/10.1038/s41598-019-56438-3 cristin:1775438 |
op_rights |
Navngivelse 4.0 Internasjonal http://creativecommons.org/licenses/by/4.0/deed.no |
op_doi |
https://doi.org/10.1038/s41598-019-56438-3 |
container_title |
Scientific Reports |
container_volume |
9 |
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1 |
_version_ |
1810432623250505728 |