Valorisation of the invasive macroalgae Undaria pinnatifida (Harvey) Suringar for the green synthesis of gold and silver nanoparticles with antimicrobial and antioxidant potential
Bacterial and fungal infections are a challenging global problem due to the reported increasing resistance of pathogenic microorganisms to conventional antimicrobials. Nanomaterials are a promising strategy to fight infections caused by multidrug-resistant microbes. In this work, gold (Au@UP) and si...
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Multidisciplinary Digital Publishing Institute (MDPI)
2023
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Online Access: | https://hdl.handle.net/1822/86996 https://doi.org/10.3390/md21070397 |
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ftunivminho:oai:repositorium.sdum.uminho.pt:1822/86996 2024-01-28T10:07:49+01:00 Valorisation of the invasive macroalgae Undaria pinnatifida (Harvey) Suringar for the green synthesis of gold and silver nanoparticles with antimicrobial and antioxidant potential González-Ballesteros, Noelia Fernandes, Mário Machado, Raul Sampaio, Paula Gomes, Andreia C. Cavazza, Antonella Bigi, Franca Rodríguez-Argüelles, Maria Carmen 2023-07-09 application/pdf https://hdl.handle.net/1822/86996 https://doi.org/10.3390/md21070397 eng eng Multidisciplinary Digital Publishing Institute (MDPI) info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04050%2F2020/PT info:eu-repo/grantAgreement/EC/HE/101099423/EU SFRH/BD/147819/2019 info:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F00526%2F2018%2FCP1581%2FCT0021/PT https://www.mdpi.com/1660-3397/21/7/397 González-Ballesteros, N.; Fernandes, M.; Machado, R.; Sampaio, P.; Gomes, A.C.; Cavazza, A.; Bigi, F.; Rodríguez-Argüelles, M.C. Valorisation of the Invasive Macroalgae Undaria pinnatifida (Harvey) Suringar for the Green Synthesis of Gold and Silver Nanoparticles with Antimicrobial and Antioxidant Potential. Mar. Drugs 2023, 21, 397. https://doi.org/10.3390/md21070397 https://hdl.handle.net/1822/86996 1660-3397 doi:10.3390/md21070397 37504928 397 info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ Undaria pinnatifida Green synthesis Silver nanoparticles Gold nanoparticles Antibacterial activity Antifungal activity info:eu-repo/semantics/article 2023 ftunivminho https://doi.org/10.3390/md21070397 2023-12-29T00:10:41Z Bacterial and fungal infections are a challenging global problem due to the reported increasing resistance of pathogenic microorganisms to conventional antimicrobials. Nanomaterials are a promising strategy to fight infections caused by multidrug-resistant microbes. In this work, gold (Au@UP) and silver (Ag@UP) nanoparticles were produced for the first time by green synthesis using an aqueous extract of the invasive macroalgae Undaria pinnatifida (UP). The nanoparticles were characterized by a wide range of physicochemical techniques. Au@UP and Ag@UP demonstrated to be spherical and crystalline with an average size of 6.8 ± 1.0 nm and 14.1 ± 2.8 nm, respectively. Carbohydrates and proteins of the UP extract may participate in the synthesis and capping of the nanoparticles. The UP extract, Ag@UP, and Au@UP were assessed for their antimicrobial activity against Escherichia coli , Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans , and Candida auris. Ag@UP showed the highest antimicrobial activity with very low MIC and MBC values for all the tested bacteria, and Au@UP demonstrated to be very effective against biofilm-producing bacteria. The antifungal properties of both Ag@UP and Au@UP were remarkable, inhibiting hyphae formation. This study points towards a very promising biomedical exploitation of this invasive brown algae. This workhas been funded by the Horizon Europe Project "PERSEUS" [grant number 101099423]. The UK participants are supported by UKRI [grant number 10073017], by Xunta de Galicia Ref.: ED431C 2018, the “Contrato-Programa” UIDB/04050/2020 through the FCT I.P., and project ATLANTIDA—the platform for the monitoring of the north Atlantic Ocean and tools for the sustainable exploitation of the marine resources operation NORTE-01-0145-FEDER-000040, cofinanced by NORTE2020 through the European Regional Development Fund (ERDF). NGB was financed by the Ministry of Universities under application 33.50.460A.752 and by the European Mar. Drugs 2023, 21, 397 16 of 18 Union ... Article in Journal/Newspaper North Atlantic Universidade of Minho: RepositóriUM Marine Drugs 21 7 397 |
institution |
Open Polar |
collection |
Universidade of Minho: RepositóriUM |
op_collection_id |
ftunivminho |
language |
English |
topic |
Undaria pinnatifida Green synthesis Silver nanoparticles Gold nanoparticles Antibacterial activity Antifungal activity |
spellingShingle |
Undaria pinnatifida Green synthesis Silver nanoparticles Gold nanoparticles Antibacterial activity Antifungal activity González-Ballesteros, Noelia Fernandes, Mário Machado, Raul Sampaio, Paula Gomes, Andreia C. Cavazza, Antonella Bigi, Franca Rodríguez-Argüelles, Maria Carmen Valorisation of the invasive macroalgae Undaria pinnatifida (Harvey) Suringar for the green synthesis of gold and silver nanoparticles with antimicrobial and antioxidant potential |
topic_facet |
Undaria pinnatifida Green synthesis Silver nanoparticles Gold nanoparticles Antibacterial activity Antifungal activity |
description |
Bacterial and fungal infections are a challenging global problem due to the reported increasing resistance of pathogenic microorganisms to conventional antimicrobials. Nanomaterials are a promising strategy to fight infections caused by multidrug-resistant microbes. In this work, gold (Au@UP) and silver (Ag@UP) nanoparticles were produced for the first time by green synthesis using an aqueous extract of the invasive macroalgae Undaria pinnatifida (UP). The nanoparticles were characterized by a wide range of physicochemical techniques. Au@UP and Ag@UP demonstrated to be spherical and crystalline with an average size of 6.8 ± 1.0 nm and 14.1 ± 2.8 nm, respectively. Carbohydrates and proteins of the UP extract may participate in the synthesis and capping of the nanoparticles. The UP extract, Ag@UP, and Au@UP were assessed for their antimicrobial activity against Escherichia coli , Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans , and Candida auris. Ag@UP showed the highest antimicrobial activity with very low MIC and MBC values for all the tested bacteria, and Au@UP demonstrated to be very effective against biofilm-producing bacteria. The antifungal properties of both Ag@UP and Au@UP were remarkable, inhibiting hyphae formation. This study points towards a very promising biomedical exploitation of this invasive brown algae. This workhas been funded by the Horizon Europe Project "PERSEUS" [grant number 101099423]. The UK participants are supported by UKRI [grant number 10073017], by Xunta de Galicia Ref.: ED431C 2018, the “Contrato-Programa” UIDB/04050/2020 through the FCT I.P., and project ATLANTIDA—the platform for the monitoring of the north Atlantic Ocean and tools for the sustainable exploitation of the marine resources operation NORTE-01-0145-FEDER-000040, cofinanced by NORTE2020 through the European Regional Development Fund (ERDF). NGB was financed by the Ministry of Universities under application 33.50.460A.752 and by the European Mar. Drugs 2023, 21, 397 16 of 18 Union ... |
format |
Article in Journal/Newspaper |
author |
González-Ballesteros, Noelia Fernandes, Mário Machado, Raul Sampaio, Paula Gomes, Andreia C. Cavazza, Antonella Bigi, Franca Rodríguez-Argüelles, Maria Carmen |
author_facet |
González-Ballesteros, Noelia Fernandes, Mário Machado, Raul Sampaio, Paula Gomes, Andreia C. Cavazza, Antonella Bigi, Franca Rodríguez-Argüelles, Maria Carmen |
author_sort |
González-Ballesteros, Noelia |
title |
Valorisation of the invasive macroalgae Undaria pinnatifida (Harvey) Suringar for the green synthesis of gold and silver nanoparticles with antimicrobial and antioxidant potential |
title_short |
Valorisation of the invasive macroalgae Undaria pinnatifida (Harvey) Suringar for the green synthesis of gold and silver nanoparticles with antimicrobial and antioxidant potential |
title_full |
Valorisation of the invasive macroalgae Undaria pinnatifida (Harvey) Suringar for the green synthesis of gold and silver nanoparticles with antimicrobial and antioxidant potential |
title_fullStr |
Valorisation of the invasive macroalgae Undaria pinnatifida (Harvey) Suringar for the green synthesis of gold and silver nanoparticles with antimicrobial and antioxidant potential |
title_full_unstemmed |
Valorisation of the invasive macroalgae Undaria pinnatifida (Harvey) Suringar for the green synthesis of gold and silver nanoparticles with antimicrobial and antioxidant potential |
title_sort |
valorisation of the invasive macroalgae undaria pinnatifida (harvey) suringar for the green synthesis of gold and silver nanoparticles with antimicrobial and antioxidant potential |
publisher |
Multidisciplinary Digital Publishing Institute (MDPI) |
publishDate |
2023 |
url |
https://hdl.handle.net/1822/86996 https://doi.org/10.3390/md21070397 |
genre |
North Atlantic |
genre_facet |
North Atlantic |
op_relation |
info:eu-repo/grantAgreement/FCT/6817 - DCRRNI ID/UIDB%2F04050%2F2020/PT info:eu-repo/grantAgreement/EC/HE/101099423/EU SFRH/BD/147819/2019 info:eu-repo/grantAgreement/FCT/CEEC IND 2018/CEECIND%2F00526%2F2018%2FCP1581%2FCT0021/PT https://www.mdpi.com/1660-3397/21/7/397 González-Ballesteros, N.; Fernandes, M.; Machado, R.; Sampaio, P.; Gomes, A.C.; Cavazza, A.; Bigi, F.; Rodríguez-Argüelles, M.C. Valorisation of the Invasive Macroalgae Undaria pinnatifida (Harvey) Suringar for the Green Synthesis of Gold and Silver Nanoparticles with Antimicrobial and Antioxidant Potential. Mar. Drugs 2023, 21, 397. https://doi.org/10.3390/md21070397 https://hdl.handle.net/1822/86996 1660-3397 doi:10.3390/md21070397 37504928 397 |
op_rights |
info:eu-repo/semantics/openAccess http://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.3390/md21070397 |
container_title |
Marine Drugs |
container_volume |
21 |
container_issue |
7 |
container_start_page |
397 |
_version_ |
1789335959909695488 |