Bioinformatics challenges and potentialities in studying extreme environments
Biological systems show impressive adaptations at extreme environments. In extreme environments, directional selection pressure mechanisms acting upon mutational events often produce functional and structural innovations. Examples are the antifreeze proteins in Antarctic fish and their lack of hemog...
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ftunivmilanobic:oai:boa.unimib.it:10281/259004 2024-04-21T07:49:53+00:00 Bioinformatics challenges and potentialities in studying extreme environments Angione C Liò P Pucciarelli S Can B Conway M LOTTI, MARINA Bukhari H Mancini A Sezerman U Telatin A. Angelini, C Rancoita, P Rovetta, S Angione, C Liò, P Pucciarelli, S Can, B Conway, M Lotti, M Bukhari, H Mancini, A Sezerman, U Telatin, A 2016 http://hdl.handle.net/10281/259004 https://doi.org/10.1007/978-3-319-44332-4_16 eng eng Springer Verlag country:CH info:eu-repo/semantics/altIdentifier/isbn/9783319443317 ispartofbook:Lecture Notes in Computer Sciences volume:9874 firstpage:205 lastpage:219 numberofpages:15 serie:LECTURE NOTES IN COMPUTER SCIENCE alleditors:Angelini, C; Rancoita, P; Rovetta, S http://hdl.handle.net/10281/259004 doi:10.1007/978-3-319-44332-4_16 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84981263663 multi-omic multi-layer networks adaptation metabolism extreme environments info:eu-repo/semantics/bookPart 2016 ftunivmilanobic https://doi.org/10.1007/978-3-319-44332-4_16 2024-03-28T01:16:08Z Biological systems show impressive adaptations at extreme environments. In extreme environments, directional selection pressure mechanisms acting upon mutational events often produce functional and structural innovations. Examples are the antifreeze proteins in Antarctic fish and their lack of hemoglobin, and the thermostable properties of TAQ polymerase from thermophilic organisms. During the past decade, more than 4000 organisms have been part of genome-sequencing projects. This has enabled the retrieval of information about evolutionary relationships among all living organisms, and has increased the understanding of complex phenomena, such as evolution, adaptation, and ecology. Bioinformatics tools have allowed us to perform genome annotation, crosscomparison, and to understand the metabolic potential of living organisms. In the last few years, research in bioinformatics has started to migrate from the analysis of genomic sequences and structural biology problems to the analysis of genotype-phenotype mapping. We believe that the analysis of multi-omic information, particularly metabolic and transcriptomic data of organisms living in extreme environments, could provide important and general insights into the how natural selection in an ecosystem shapes the molecular constituents. Here we present a review of methods with the aim to bridge the gap between theoretical models, bioinformatics analysis and experimental settings. The amount of data suggests that bioinformatics could be used to investigate whether the adaptation is generated by interesting molecular inventions.We therefore review and discuss the methodology and tools to approach this challenge. Book Part Antarc* Antarctic Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) 205 219 |
institution |
Open Polar |
collection |
Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
op_collection_id |
ftunivmilanobic |
language |
English |
topic |
multi-omic multi-layer networks adaptation metabolism extreme environments |
spellingShingle |
multi-omic multi-layer networks adaptation metabolism extreme environments Angione C Liò P Pucciarelli S Can B Conway M LOTTI, MARINA Bukhari H Mancini A Sezerman U Telatin A. Bioinformatics challenges and potentialities in studying extreme environments |
topic_facet |
multi-omic multi-layer networks adaptation metabolism extreme environments |
description |
Biological systems show impressive adaptations at extreme environments. In extreme environments, directional selection pressure mechanisms acting upon mutational events often produce functional and structural innovations. Examples are the antifreeze proteins in Antarctic fish and their lack of hemoglobin, and the thermostable properties of TAQ polymerase from thermophilic organisms. During the past decade, more than 4000 organisms have been part of genome-sequencing projects. This has enabled the retrieval of information about evolutionary relationships among all living organisms, and has increased the understanding of complex phenomena, such as evolution, adaptation, and ecology. Bioinformatics tools have allowed us to perform genome annotation, crosscomparison, and to understand the metabolic potential of living organisms. In the last few years, research in bioinformatics has started to migrate from the analysis of genomic sequences and structural biology problems to the analysis of genotype-phenotype mapping. We believe that the analysis of multi-omic information, particularly metabolic and transcriptomic data of organisms living in extreme environments, could provide important and general insights into the how natural selection in an ecosystem shapes the molecular constituents. Here we present a review of methods with the aim to bridge the gap between theoretical models, bioinformatics analysis and experimental settings. The amount of data suggests that bioinformatics could be used to investigate whether the adaptation is generated by interesting molecular inventions.We therefore review and discuss the methodology and tools to approach this challenge. |
author2 |
Angelini, C Rancoita, P Rovetta, S Angione, C Liò, P Pucciarelli, S Can, B Conway, M Lotti, M Bukhari, H Mancini, A Sezerman, U Telatin, A |
format |
Book Part |
author |
Angione C Liò P Pucciarelli S Can B Conway M LOTTI, MARINA Bukhari H Mancini A Sezerman U Telatin A. |
author_facet |
Angione C Liò P Pucciarelli S Can B Conway M LOTTI, MARINA Bukhari H Mancini A Sezerman U Telatin A. |
author_sort |
Angione C |
title |
Bioinformatics challenges and potentialities in studying extreme environments |
title_short |
Bioinformatics challenges and potentialities in studying extreme environments |
title_full |
Bioinformatics challenges and potentialities in studying extreme environments |
title_fullStr |
Bioinformatics challenges and potentialities in studying extreme environments |
title_full_unstemmed |
Bioinformatics challenges and potentialities in studying extreme environments |
title_sort |
bioinformatics challenges and potentialities in studying extreme environments |
publisher |
Springer Verlag |
publishDate |
2016 |
url |
http://hdl.handle.net/10281/259004 https://doi.org/10.1007/978-3-319-44332-4_16 |
genre |
Antarc* Antarctic |
genre_facet |
Antarc* Antarctic |
op_relation |
info:eu-repo/semantics/altIdentifier/isbn/9783319443317 ispartofbook:Lecture Notes in Computer Sciences volume:9874 firstpage:205 lastpage:219 numberofpages:15 serie:LECTURE NOTES IN COMPUTER SCIENCE alleditors:Angelini, C; Rancoita, P; Rovetta, S http://hdl.handle.net/10281/259004 doi:10.1007/978-3-319-44332-4_16 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84981263663 |
op_doi |
https://doi.org/10.1007/978-3-319-44332-4_16 |
container_start_page |
205 |
op_container_end_page |
219 |
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