Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides
Supported lipase from Candida antarctica (Chirazyme®) was employed for a regioselective protection of the 2-azido derivatives 1 and 2, synthetic equivalents of β-D-Gal(1→3)-D-GlcNAc and β-D-Gal(1→4)-D-GlcNAc (N-acetyl lactosamine), respectively. The selectivity of the enzyme towards 1 and 2 was also...
| Published in: | Tetrahedron: Asymmetry |
|---|---|
| Main Authors: | , , , |
| Other Authors: | , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Pergamon
2000
|
| Subjects: | |
| Online Access: | http://hdl.handle.net/10281/17012 https://doi.org/10.1016/S0957-4166(00)00342-6 |
| _version_ | 1833106753934327808 |
|---|---|
| author | LA FERLA, BARBARA Lay, L Russo, G Panza, L. |
| author2 | LA FERLA, B Lay, L Russo, G Panza, L |
| author_facet | LA FERLA, BARBARA Lay, L Russo, G Panza, L. |
| author_sort | LA FERLA, BARBARA |
| collection | Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) |
| container_issue | 18 |
| container_start_page | 3647 |
| container_title | Tetrahedron: Asymmetry |
| container_volume | 11 |
| description | Supported lipase from Candida antarctica (Chirazyme®) was employed for a regioselective protection of the 2-azido derivatives 1 and 2, synthetic equivalents of β-D-Gal(1→3)-D-GlcNAc and β-D-Gal(1→4)-D-GlcNAc (N-acetyl lactosamine), respectively. The selectivity of the enzyme towards 1 and 2 was also exploited for an easy separation of the mixture of the two compounds obtained from a straightforward synthetic approach. Copyright (C) 2000 Elsevier Science Ltd. |
| format | Article in Journal/Newspaper |
| genre | Antarc* Antarctica |
| genre_facet | Antarc* Antarctica |
| id | ftunivmilanobic:oai:boa.unimib.it:10281/17012 |
| institution | Open Polar |
| language | English |
| op_collection_id | ftunivmilanobic |
| op_container_end_page | 3651 |
| op_doi | https://doi.org/10.1016/S0957-4166(00)00342-6 |
| op_relation | info:eu-repo/semantics/altIdentifier/wos/WOS:000165324600001 volume:11 issue:18 firstpage:3647 lastpage:3651 numberofpages:5 journal:TETRAHEDRON-ASYMMETRY http://hdl.handle.net/10281/17012 |
| publishDate | 2000 |
| publisher | Pergamon |
| record_format | openpolar |
| spelling | ftunivmilanobic:oai:boa.unimib.it:10281/17012 2025-05-25T13:44:53+00:00 Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides LA FERLA, BARBARA Lay, L Russo, G Panza, L. LA FERLA, B Lay, L Russo, G Panza, L 2000 http://hdl.handle.net/10281/17012 https://doi.org/10.1016/S0957-4166(00)00342-6 eng eng Pergamon info:eu-repo/semantics/altIdentifier/wos/WOS:000165324600001 volume:11 issue:18 firstpage:3647 lastpage:3651 numberofpages:5 journal:TETRAHEDRON-ASYMMETRY http://hdl.handle.net/10281/17012 regioselectivity carbohydrate info:eu-repo/semantics/article 2000 ftunivmilanobic https://doi.org/10.1016/S0957-4166(00)00342-6 2025-04-28T01:57:17Z Supported lipase from Candida antarctica (Chirazyme®) was employed for a regioselective protection of the 2-azido derivatives 1 and 2, synthetic equivalents of β-D-Gal(1→3)-D-GlcNAc and β-D-Gal(1→4)-D-GlcNAc (N-acetyl lactosamine), respectively. The selectivity of the enzyme towards 1 and 2 was also exploited for an easy separation of the mixture of the two compounds obtained from a straightforward synthetic approach. Copyright (C) 2000 Elsevier Science Ltd. Article in Journal/Newspaper Antarc* Antarctica Università degli Studi di Milano-Bicocca: BOA (Bicocca Open Archive) Tetrahedron: Asymmetry 11 18 3647 3651 |
| spellingShingle | regioselectivity carbohydrate LA FERLA, BARBARA Lay, L Russo, G Panza, L. Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides |
| title | Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides |
| title_full | Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides |
| title_fullStr | Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides |
| title_full_unstemmed | Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides |
| title_short | Regioselective lipase acylation as a useful tool for separation and selective protection of β-D-Gal(1→4)-D-GlcNAc and β-D-Gal(1→3)-D-GlcNAc disaccharides |
| title_sort | regioselective lipase acylation as a useful tool for separation and selective protection of β-d-gal(1→4)-d-glcnac and β-d-gal(1→3)-d-glcnac disaccharides |
| topic | regioselectivity carbohydrate |
| topic_facet | regioselectivity carbohydrate |
| url | http://hdl.handle.net/10281/17012 https://doi.org/10.1016/S0957-4166(00)00342-6 |