Adiponectin, leptin, cortisol, neuropeptide Y and profile of mood states in athletes participating in an ultramarathon during winter: An observational study

• Published in: Frontiers in Physiology
• Main Authors: Kienast, Camilla, Biere, Katharina, Coker, Robert H, Genov, Nikolai N, Jörres, Marc, Maggioni, Martina Anna, Mascarell-Maricic, Lea, Schalt, Adriane, Genov, Magdalena, Gunga, Hanns-Christian, Steinach, Mathias
• Other Authors: C. Kienast, K. Biere, R.H. Coker, N.N. Genov, M. Jörre, M.A. Maggioni, L. Mascarell-Maricic, A. Schalt, M. Genov, H. Gunga, M. Steinach
• Format: Article in Journal/Newspaper
• Language: English
• Published: Frontiers Research Foundation 2022
• Subjects: NPY (neuropeptide Y); adiponectin; cold climate; leptin; profile of mood states (POMS); ultramarathon; Settore BIO/09 - Fisiologia; Arctic; Yukon
• Online Access: https://hdl.handle.net/2434/951729; https://doi.org/10.3389/fphys.2022.970016

Background: The Montane® Yukon Arctic Ultra (YAU) is one of the longest (690km) and coldest (+10.6°C-43.9°C) ultramarathons worldwide. Taking part in an ultramarathon is associated with great physiological and psychological stress, which can affect one's mood, level of hormones, and peptides. The current study aimed to identify relationships between peptides, hormones, and mood states in participants during this ultramarathon. Methods: The study cohort consisted of 36 participants (19 men, 17 women, 38.64 ± 9.12years) split into a finisher (n = 10), non-finisher (n = 19), and control group (n = 7). Data were collected at four time points: baseline (PRE), during (D1 after 277km, D2 after 383km), and after the race (POST). Questionnaires were used to assess ratings of perceived exertion (RPE), total quality of recovery (TQR), and profile of mood states (POMS-SF). Serum NPY, leptin, adiponectin, and cortisol were measured. Results: Among non-finishers, scores for confusion, anger, depression, and tension-anxiety (PRE vs. D2, p < 0.05) increased, while vigor decreased (PRE vs. D1, p < 0.05). In contrast, finishers' tension-anxiety scores decreased (PRE vs. D1, p < 0.05). Fatigue increased in finishers (PRE vs. POST, p < 0.05) and non-finishers (PRE vs. D1, p < 0.05). In non-finishers, depressive mood correlated positively with leptin, anger, and confusion at several time points (p < 0.001). In finishers, NPY correlated with TQR at PRE (p < 0.05), while leptin correlated negatively with TQR at POST (p < 0.05). Tension-anxiety correlated highly with perceived exertion in non-finishers (p < 0.001) and with cortisol in finishers (p < 0.05) and non-finishers (p < 0.001). In finishers, confusion correlated negatively with NPY (p < 0.01). Conclusion: The study reveals an essential interplay between hormones and mood states affecting performance: Leptin was associated with anger and a depressive mood state in non-finishers and worse recovery in finishers. In contrast, NPY appeared linked ...