You will never walk alone : co-dispersal of JC polyomavirus with human populations
JC polyomavirus (JCPyV) is one of the most prevalent human viruses. Findings based on the geographic distribution of viral subtypes suggested that JCPyV codiverged with human populations. This view was however challenged by data reporting a much more recent origin and expansion of JCPyV. We collecte...
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Online Access: | http://hdl.handle.net/2434/779339 https://doi.org/10.1093/molbev/msz227 |
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ftunivmilanoair:oai:air.unimi.it:2434/779339 2024-02-11T10:01:35+01:00 You will never walk alone : co-dispersal of JC polyomavirus with human populations D Forni R Cagliani M Clerici U Pozzoli M Sironi D. Forni R. Cagliani M. Clerici U. Pozzoli M. Sironi 2020-02 http://hdl.handle.net/2434/779339 https://doi.org/10.1093/molbev/msz227 eng eng Oxford University press info:eu-repo/semantics/altIdentifier/pmid/31593241 info:eu-repo/semantics/altIdentifier/wos/WOS:000518533800012 volume:42 issue:2 firstpage:442 lastpage:454 numberofpages:13 journal:MOLECULAR BIOLOGY AND EVOLUTION http://hdl.handle.net/2434/779339 doi:10.1093/molbev/msz227 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85076831640 info:eu-repo/semantics/openAccess JC polyomaviru codispersal human population phylogeography molecular dating Settore MED/04 - Patologia Generale info:eu-repo/semantics/article 2020 ftunivmilanoair https://doi.org/10.1093/molbev/msz227 2024-01-23T23:40:45Z JC polyomavirus (JCPyV) is one of the most prevalent human viruses. Findings based on the geographic distribution of viral subtypes suggested that JCPyV codiverged with human populations. This view was however challenged by data reporting a much more recent origin and expansion of JCPyV. We collected information on ∼1,100 worldwide strains and we show that their geographic distribution roughly corresponds to major human migratory routes. Bayesian phylogeographic analysis inferred a Subsaharan origin for JCPyV, although with low posterior probability. High confidence inference at internal nodes provided strong support for a long-standing association between the virus and human populations. In line with these data, pairwise FST values for JCPyV and human mtDNA sampled from the same areas showed a positive and significant correlation. Likewise, very strong relationships were found when node ages in the JCPyV phylogeny were correlated with human population genetic distances (nuclear-marker based FST). Reconciliation analysis detected a significant cophylogenetic signal for the human population and JCPyV trees. Notably, JCPyV also traced some relatively recent migration events such as the expansion of people from the Philippines/Taiwan area into Remote Oceania, the gene flow between North-Eastern Siberian and Ainus, and the Koryak contribution to Circum-Arctic Americans. Finally, different molecular dating approaches dated the origin of JCPyV in a time frame that precedes human out-of-Africa migration. Thus, JCPyV infected early human populations and accompanied our species during worldwide dispersal. JCPyV typing can provide reliable geographic information and the virus most likely adapted to the genetic background of human populations. Article in Journal/Newspaper Arctic Koryak The University of Milan: Archivio Istituzionale della Ricerca (AIR) Arctic Molecular Biology and Evolution 37 2 442 454 |
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Open Polar |
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The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
op_collection_id |
ftunivmilanoair |
language |
English |
topic |
JC polyomaviru codispersal human population phylogeography molecular dating Settore MED/04 - Patologia Generale |
spellingShingle |
JC polyomaviru codispersal human population phylogeography molecular dating Settore MED/04 - Patologia Generale D Forni R Cagliani M Clerici U Pozzoli M Sironi You will never walk alone : co-dispersal of JC polyomavirus with human populations |
topic_facet |
JC polyomaviru codispersal human population phylogeography molecular dating Settore MED/04 - Patologia Generale |
description |
JC polyomavirus (JCPyV) is one of the most prevalent human viruses. Findings based on the geographic distribution of viral subtypes suggested that JCPyV codiverged with human populations. This view was however challenged by data reporting a much more recent origin and expansion of JCPyV. We collected information on ∼1,100 worldwide strains and we show that their geographic distribution roughly corresponds to major human migratory routes. Bayesian phylogeographic analysis inferred a Subsaharan origin for JCPyV, although with low posterior probability. High confidence inference at internal nodes provided strong support for a long-standing association between the virus and human populations. In line with these data, pairwise FST values for JCPyV and human mtDNA sampled from the same areas showed a positive and significant correlation. Likewise, very strong relationships were found when node ages in the JCPyV phylogeny were correlated with human population genetic distances (nuclear-marker based FST). Reconciliation analysis detected a significant cophylogenetic signal for the human population and JCPyV trees. Notably, JCPyV also traced some relatively recent migration events such as the expansion of people from the Philippines/Taiwan area into Remote Oceania, the gene flow between North-Eastern Siberian and Ainus, and the Koryak contribution to Circum-Arctic Americans. Finally, different molecular dating approaches dated the origin of JCPyV in a time frame that precedes human out-of-Africa migration. Thus, JCPyV infected early human populations and accompanied our species during worldwide dispersal. JCPyV typing can provide reliable geographic information and the virus most likely adapted to the genetic background of human populations. |
author2 |
D. Forni R. Cagliani M. Clerici U. Pozzoli M. Sironi |
format |
Article in Journal/Newspaper |
author |
D Forni R Cagliani M Clerici U Pozzoli M Sironi |
author_facet |
D Forni R Cagliani M Clerici U Pozzoli M Sironi |
author_sort |
D Forni |
title |
You will never walk alone : co-dispersal of JC polyomavirus with human populations |
title_short |
You will never walk alone : co-dispersal of JC polyomavirus with human populations |
title_full |
You will never walk alone : co-dispersal of JC polyomavirus with human populations |
title_fullStr |
You will never walk alone : co-dispersal of JC polyomavirus with human populations |
title_full_unstemmed |
You will never walk alone : co-dispersal of JC polyomavirus with human populations |
title_sort |
you will never walk alone : co-dispersal of jc polyomavirus with human populations |
publisher |
Oxford University press |
publishDate |
2020 |
url |
http://hdl.handle.net/2434/779339 https://doi.org/10.1093/molbev/msz227 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Koryak |
genre_facet |
Arctic Koryak |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/31593241 info:eu-repo/semantics/altIdentifier/wos/WOS:000518533800012 volume:42 issue:2 firstpage:442 lastpage:454 numberofpages:13 journal:MOLECULAR BIOLOGY AND EVOLUTION http://hdl.handle.net/2434/779339 doi:10.1093/molbev/msz227 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85076831640 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1093/molbev/msz227 |
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Molecular Biology and Evolution |
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37 |
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2 |
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442 |
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