Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE-Deficient Mice
SCOPE: Antarctic krill is a great source of n-3 fatty acids and high-quality proteins. Aim of the study was to evaluate the effect of Antarctic krill components on plasma lipids and atherosclerosis development. METHODS AND RESULTS: Sixty apoEKO mice were divided into four groups and fed Western diet...
Published in: | Molecular Nutrition & Food Research |
---|---|
Main Authors: | , , , , , , , , , |
Other Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley
2017
|
Subjects: | |
Online Access: | http://hdl.handle.net/2434/529717 https://doi.org/10.1002/mnfr.201700098 |
id |
ftunivmilanoair:oai:air.unimi.it:2434/529717 |
---|---|
record_format |
openpolar |
spelling |
ftunivmilanoair:oai:air.unimi.it:2434/529717 2024-02-11T09:57:33+01:00 Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE-Deficient Mice C. Parolini Bjorndal, Bodil M. Busnelli S. Manzini G.S. Ganzetti F. Dellera Ramsvik, Marie Bruheim, Inge Berge, Rolf Kristian G.M. Chiesa C. Parolini B. Bodil M. Busnelli S. Manzini G.S. Ganzetti F. Dellera R. Marie B. Inge B. Rolf Kristian G.M. Chiesa 2017-12 http://hdl.handle.net/2434/529717 https://doi.org/10.1002/mnfr.201700098 eng eng Wiley info:eu-repo/semantics/altIdentifier/pmid/28812326 info:eu-repo/semantics/altIdentifier/wos/WOS:000417459400009 volume:61 issue:12 firstpage:1 lastpage:10 numberofpages:10 journal:MOLECULAR NUTRITION & FOOD RESEARCH http://hdl.handle.net/2434/529717 doi:10.1002/mnfr.201700098 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85037573906 info:eu-repo/semantics/closedAccess antarctic krill apoE-deficient mice atherosclerosi krill oil krill protein Settore BIO/14 - Farmacologia Settore BIO/16 - Anatomia Umana Settore BIO/17 - Istologia info:eu-repo/semantics/article 2017 ftunivmilanoair https://doi.org/10.1002/mnfr.201700098 2024-01-23T23:39:56Z SCOPE: Antarctic krill is a great source of n-3 fatty acids and high-quality proteins. Aim of the study was to evaluate the effect of Antarctic krill components on plasma lipids and atherosclerosis development. METHODS AND RESULTS: Sixty apoEKO mice were divided into four groups and fed Western diet (CONTROL) or Western-like diets, differing for protein or fat content. Specifically, casein or fat in CONTROL was partially replaced by krill proteins (PRO), krill oil (KRILL OIL), or both (KRILL OIL+PRO). In KRILL OIL+PRO and KRILL OIL, cholesterol levels were significantly lower than in CONTROL group. Atherosclerosis in aorta of PRO, KRILL OIL and KRILL OIL+PRO was lower than in CONTROL, whereas, at the aortic sinus, atherosclerosis reduction was only observed in KRILL OIL. Liver steatosis, commonly present in CONTROL and PRO animals, was sporadic in KRILL OIL+PRO and KRILL OIL mice. Krill oil containing diets affected the expression of genes involved in cholesterol metabolism, mainly HMG-CoA reductase. No reduced systemic inflammation was found in all groups. CONCLUSION: Krill oil containing diets were able to reduce cholesterol levels, inhibit plaque development and prevent liver damage. Krill proteins also reduced atherosclerosis development through mechanisms not involving lipid metabolism. Article in Journal/Newspaper Antarc* Antarctic Antarctic Krill The University of Milan: Archivio Istituzionale della Ricerca (AIR) Antarctic Molecular Nutrition & Food Research 61 12 1700098 |
institution |
Open Polar |
collection |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
op_collection_id |
ftunivmilanoair |
language |
English |
topic |
antarctic krill apoE-deficient mice atherosclerosi krill oil krill protein Settore BIO/14 - Farmacologia Settore BIO/16 - Anatomia Umana Settore BIO/17 - Istologia |
spellingShingle |
antarctic krill apoE-deficient mice atherosclerosi krill oil krill protein Settore BIO/14 - Farmacologia Settore BIO/16 - Anatomia Umana Settore BIO/17 - Istologia C. Parolini Bjorndal, Bodil M. Busnelli S. Manzini G.S. Ganzetti F. Dellera Ramsvik, Marie Bruheim, Inge Berge, Rolf Kristian G.M. Chiesa Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE-Deficient Mice |
topic_facet |
antarctic krill apoE-deficient mice atherosclerosi krill oil krill protein Settore BIO/14 - Farmacologia Settore BIO/16 - Anatomia Umana Settore BIO/17 - Istologia |
description |
SCOPE: Antarctic krill is a great source of n-3 fatty acids and high-quality proteins. Aim of the study was to evaluate the effect of Antarctic krill components on plasma lipids and atherosclerosis development. METHODS AND RESULTS: Sixty apoEKO mice were divided into four groups and fed Western diet (CONTROL) or Western-like diets, differing for protein or fat content. Specifically, casein or fat in CONTROL was partially replaced by krill proteins (PRO), krill oil (KRILL OIL), or both (KRILL OIL+PRO). In KRILL OIL+PRO and KRILL OIL, cholesterol levels were significantly lower than in CONTROL group. Atherosclerosis in aorta of PRO, KRILL OIL and KRILL OIL+PRO was lower than in CONTROL, whereas, at the aortic sinus, atherosclerosis reduction was only observed in KRILL OIL. Liver steatosis, commonly present in CONTROL and PRO animals, was sporadic in KRILL OIL+PRO and KRILL OIL mice. Krill oil containing diets affected the expression of genes involved in cholesterol metabolism, mainly HMG-CoA reductase. No reduced systemic inflammation was found in all groups. CONCLUSION: Krill oil containing diets were able to reduce cholesterol levels, inhibit plaque development and prevent liver damage. Krill proteins also reduced atherosclerosis development through mechanisms not involving lipid metabolism. |
author2 |
C. Parolini B. Bodil M. Busnelli S. Manzini G.S. Ganzetti F. Dellera R. Marie B. Inge B. Rolf Kristian G.M. Chiesa |
format |
Article in Journal/Newspaper |
author |
C. Parolini Bjorndal, Bodil M. Busnelli S. Manzini G.S. Ganzetti F. Dellera Ramsvik, Marie Bruheim, Inge Berge, Rolf Kristian G.M. Chiesa |
author_facet |
C. Parolini Bjorndal, Bodil M. Busnelli S. Manzini G.S. Ganzetti F. Dellera Ramsvik, Marie Bruheim, Inge Berge, Rolf Kristian G.M. Chiesa |
author_sort |
C. Parolini |
title |
Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE-Deficient Mice |
title_short |
Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE-Deficient Mice |
title_full |
Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE-Deficient Mice |
title_fullStr |
Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE-Deficient Mice |
title_full_unstemmed |
Effect of Dietary Components from Antarctic Krill on Atherosclerosis in apoE-Deficient Mice |
title_sort |
effect of dietary components from antarctic krill on atherosclerosis in apoe-deficient mice |
publisher |
Wiley |
publishDate |
2017 |
url |
http://hdl.handle.net/2434/529717 https://doi.org/10.1002/mnfr.201700098 |
geographic |
Antarctic |
geographic_facet |
Antarctic |
genre |
Antarc* Antarctic Antarctic Krill |
genre_facet |
Antarc* Antarctic Antarctic Krill |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/28812326 info:eu-repo/semantics/altIdentifier/wos/WOS:000417459400009 volume:61 issue:12 firstpage:1 lastpage:10 numberofpages:10 journal:MOLECULAR NUTRITION & FOOD RESEARCH http://hdl.handle.net/2434/529717 doi:10.1002/mnfr.201700098 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85037573906 |
op_rights |
info:eu-repo/semantics/closedAccess |
op_doi |
https://doi.org/10.1002/mnfr.201700098 |
container_title |
Molecular Nutrition & Food Research |
container_volume |
61 |
container_issue |
12 |
container_start_page |
1700098 |
_version_ |
1790593086878908416 |