Synthesis of the immunosuppressive agent 2-morpholinoethyl mycophenolate by a lipase-catalyzed transesterification
The synthesis of 2-morpholinoethyl mycophenolate was realized by an enzymic transesterification of simple esters of mycophenolic acid with 2-morpholinoethanol. Best results were achieved by a Candida antarctica lipase B (CAL B) catalyzed transesterification of Et mycophenolate in toluene. CAL B show...
| Published in: | Biocatalysis and Biotransformation |
|---|---|
| Main Authors: | , , , |
| Format: | Article in Journal/Newspaper |
| Language: | English |
| Published: |
Taylor & Francis
2006
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| Subjects: | |
| Online Access: | http://hdl.handle.net/2434/24670 https://doi.org/10.1080/10242420500520975 |
| _version_ | 1821750817685766144 |
|---|---|
| author | P. Ferraboschi P. Grisenti D. Pengo P. Prestileo |
| author2 | P. Ferraboschi P. Grisenti D. Pengo P. Prestileo |
| author_facet | P. Ferraboschi P. Grisenti D. Pengo P. Prestileo |
| author_sort | P. Ferraboschi |
| collection | The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
| container_issue | 3 |
| container_start_page | 209 |
| container_title | Biocatalysis and Biotransformation |
| container_volume | 24 |
| description | The synthesis of 2-morpholinoethyl mycophenolate was realized by an enzymic transesterification of simple esters of mycophenolic acid with 2-morpholinoethanol. Best results were achieved by a Candida antarctica lipase B (CAL B) catalyzed transesterification of Et mycophenolate in toluene. CAL B showed to selectively transform only the Et ester function leaving unreacted the other functional groups present on the substrate. By this way 2-morpholinoethyl mycophenolate was obtained in satisfactory yields from mycophenolic acid (84%). |
| format | Article in Journal/Newspaper |
| genre | Antarc* Antarctica |
| genre_facet | Antarc* Antarctica |
| id | ftunivmilanoair:oai:air.unimi.it:2434/24670 |
| institution | Open Polar |
| language | English |
| op_collection_id | ftunivmilanoair |
| op_container_end_page | 213 |
| op_doi | https://doi.org/10.1080/10242420500520975 |
| op_relation | info:eu-repo/semantics/altIdentifier/wos/WOS:000239382800005 volume:24 issue:3 firstpage:209 lastpage:213 journal:BIOCATALYSIS AND BIOTRANSFORMATION http://hdl.handle.net/2434/24670 doi:10.1080/10242420500520975 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33748349202 |
| publishDate | 2006 |
| publisher | Taylor & Francis |
| record_format | openpolar |
| spelling | ftunivmilanoair:oai:air.unimi.it:2434/24670 2025-01-16T19:21:27+00:00 Synthesis of the immunosuppressive agent 2-morpholinoethyl mycophenolate by a lipase-catalyzed transesterification P. Ferraboschi P. Grisenti D. Pengo P. Prestileo P. Ferraboschi P. Grisenti D. Pengo P. Prestileo 2006-05 http://hdl.handle.net/2434/24670 https://doi.org/10.1080/10242420500520975 eng eng Taylor & Francis info:eu-repo/semantics/altIdentifier/wos/WOS:000239382800005 volume:24 issue:3 firstpage:209 lastpage:213 journal:BIOCATALYSIS AND BIOTRANSFORMATION http://hdl.handle.net/2434/24670 doi:10.1080/10242420500520975 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-33748349202 Biocatalyzed transesterification Candida antarctica lipase B Immunosuppressant Mycophenolate mofetil Settore BIO/10 - Biochimica info:eu-repo/semantics/article 2006 ftunivmilanoair https://doi.org/10.1080/10242420500520975 2024-01-23T23:17:28Z The synthesis of 2-morpholinoethyl mycophenolate was realized by an enzymic transesterification of simple esters of mycophenolic acid with 2-morpholinoethanol. Best results were achieved by a Candida antarctica lipase B (CAL B) catalyzed transesterification of Et mycophenolate in toluene. CAL B showed to selectively transform only the Et ester function leaving unreacted the other functional groups present on the substrate. By this way 2-morpholinoethyl mycophenolate was obtained in satisfactory yields from mycophenolic acid (84%). Article in Journal/Newspaper Antarc* Antarctica The University of Milan: Archivio Istituzionale della Ricerca (AIR) Biocatalysis and Biotransformation 24 3 209 213 |
| spellingShingle | Biocatalyzed transesterification Candida antarctica lipase B Immunosuppressant Mycophenolate mofetil Settore BIO/10 - Biochimica P. Ferraboschi P. Grisenti D. Pengo P. Prestileo Synthesis of the immunosuppressive agent 2-morpholinoethyl mycophenolate by a lipase-catalyzed transesterification |
| title | Synthesis of the immunosuppressive agent 2-morpholinoethyl mycophenolate by a lipase-catalyzed transesterification |
| title_full | Synthesis of the immunosuppressive agent 2-morpholinoethyl mycophenolate by a lipase-catalyzed transesterification |
| title_fullStr | Synthesis of the immunosuppressive agent 2-morpholinoethyl mycophenolate by a lipase-catalyzed transesterification |
| title_full_unstemmed | Synthesis of the immunosuppressive agent 2-morpholinoethyl mycophenolate by a lipase-catalyzed transesterification |
| title_short | Synthesis of the immunosuppressive agent 2-morpholinoethyl mycophenolate by a lipase-catalyzed transesterification |
| title_sort | synthesis of the immunosuppressive agent 2-morpholinoethyl mycophenolate by a lipase-catalyzed transesterification |
| topic | Biocatalyzed transesterification Candida antarctica lipase B Immunosuppressant Mycophenolate mofetil Settore BIO/10 - Biochimica |
| topic_facet | Biocatalyzed transesterification Candida antarctica lipase B Immunosuppressant Mycophenolate mofetil Settore BIO/10 - Biochimica |
| url | http://hdl.handle.net/2434/24670 https://doi.org/10.1080/10242420500520975 |