Synthesis of the immunosuppressive agent 2-morpholinoethyl mycophenolate by a lipase-catalyzed transesterification
The synthesis of 2-morpholinoethyl mycophenolate was realized by an enzymic transesterification of simple esters of mycophenolic acid with 2-morpholinoethanol. Best results were achieved by a Candida antarctica lipase B (CAL B) catalyzed transesterification of Et mycophenolate in toluene. CAL B show...
Published in: | Biocatalysis and Biotransformation |
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Main Authors: | , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Taylor & Francis
2006
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Subjects: | |
Online Access: | http://hdl.handle.net/2434/24670 https://doi.org/10.1080/10242420500520975 |
Summary: | The synthesis of 2-morpholinoethyl mycophenolate was realized by an enzymic transesterification of simple esters of mycophenolic acid with 2-morpholinoethanol. Best results were achieved by a Candida antarctica lipase B (CAL B) catalyzed transesterification of Et mycophenolate in toluene. CAL B showed to selectively transform only the Et ester function leaving unreacted the other functional groups present on the substrate. By this way 2-morpholinoethyl mycophenolate was obtained in satisfactory yields from mycophenolic acid (84%). |
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