Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only
The effects of dietary interventions, based on changes of total fat, saturated fatty acids and cholesterol contents and of the polyunsaturated/saturated (P/S) fatty acid ratio of the diet, were studied in normal male and female subjects, living in North Karelia, Finland, and South Italy. In North Ka...
Published in: | Atherosclerosis |
---|---|
Main Authors: | , , , , , , , , , |
Other Authors: | |
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Elsevier
1986
|
Subjects: | |
Online Access: | http://hdl.handle.net/2434/188712 https://doi.org/10.1016/0021-9150(86)90038-9 |
id |
ftunivmilanoair:oai:air.unimi.it:2434/188712 |
---|---|
record_format |
openpolar |
spelling |
ftunivmilanoair:oai:air.unimi.it:2434/188712 2024-02-11T10:05:25+01:00 Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only E. Tremoli A. Petroni S. Colli R. Paoletti C. Galli A. Socini P. Maderna A. Ferro Luzzi P. Strazzullo M. Mancini E. Tremoli A. Petroni A. Socini P. Maderna S. Colli R. Paoletti C. Galli A. Ferro-Luzzi P. Strazzullo M. Mancini 1986-02 http://hdl.handle.net/2434/188712 https://doi.org/10.1016/0021-9150(86)90038-9 eng eng Elsevier info:eu-repo/semantics/altIdentifier/pmid/3964338 info:eu-repo/semantics/altIdentifier/wos/WOS:A1986A393100001 volume:59 issue:2 firstpage:101 lastpage:111 journal:ATHEROSCLEROSIS http://hdl.handle.net/2434/188712 doi:10.1016/0021-9150(86)90038-9 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0022638750 Sex Factors Finland Humans Lipids Thromboxane B2 Fatty Acids Cholesterol Italy Collagen Coronary Disease Blood Platelets Unsaturated Lipoproteins Adult Middle Aged Dietary Fats Male Female Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica Settore BIO/14 - Farmacologia info:eu-repo/semantics/article 1986 ftunivmilanoair https://doi.org/10.1016/0021-9150(86)90038-9 2024-01-16T23:20:11Z The effects of dietary interventions, based on changes of total fat, saturated fatty acids and cholesterol contents and of the polyunsaturated/saturated (P/S) fatty acid ratio of the diet, were studied in normal male and female subjects, living in North Karelia, Finland, and South Italy. In North Karelia the increase of P/S ratio (from 0.15 to 1.2) of the diet for a 6-week period resulted in reduced thromboxane B2 (TxB2) production by collagen-stimulated platelets only in male subjects, whereas plasma total, LDL and HDL cholesterol were reduced in both sexes. After a 6-week return to the original diet, plasma lipid levels were restored in all subjects. In the South Italy study, changes in platelet TxB2 production were observed only after return to the original diet in male subjects. Total and LDL cholesterol were significantly increased during the dietary intervention and returned toward baseline levels after switch back to the original diet. These data indicate that the increase of the P/S ratio in the diet reduces platelet TxB2 formation only in men. Article in Journal/Newspaper karelia* The University of Milan: Archivio Istituzionale della Ricerca (AIR) Atherosclerosis 59 2 101 111 |
institution |
Open Polar |
collection |
The University of Milan: Archivio Istituzionale della Ricerca (AIR) |
op_collection_id |
ftunivmilanoair |
language |
English |
topic |
Sex Factors Finland Humans Lipids Thromboxane B2 Fatty Acids Cholesterol Italy Collagen Coronary Disease Blood Platelets Unsaturated Lipoproteins Adult Middle Aged Dietary Fats Male Female Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica Settore BIO/14 - Farmacologia |
spellingShingle |
Sex Factors Finland Humans Lipids Thromboxane B2 Fatty Acids Cholesterol Italy Collagen Coronary Disease Blood Platelets Unsaturated Lipoproteins Adult Middle Aged Dietary Fats Male Female Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica Settore BIO/14 - Farmacologia E. Tremoli A. Petroni S. Colli R. Paoletti C. Galli A. Socini P. Maderna A. Ferro Luzzi P. Strazzullo M. Mancini Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only |
topic_facet |
Sex Factors Finland Humans Lipids Thromboxane B2 Fatty Acids Cholesterol Italy Collagen Coronary Disease Blood Platelets Unsaturated Lipoproteins Adult Middle Aged Dietary Fats Male Female Settore BIO/12 - Biochimica Clinica e Biologia Molecolare Clinica Settore BIO/14 - Farmacologia |
description |
The effects of dietary interventions, based on changes of total fat, saturated fatty acids and cholesterol contents and of the polyunsaturated/saturated (P/S) fatty acid ratio of the diet, were studied in normal male and female subjects, living in North Karelia, Finland, and South Italy. In North Karelia the increase of P/S ratio (from 0.15 to 1.2) of the diet for a 6-week period resulted in reduced thromboxane B2 (TxB2) production by collagen-stimulated platelets only in male subjects, whereas plasma total, LDL and HDL cholesterol were reduced in both sexes. After a 6-week return to the original diet, plasma lipid levels were restored in all subjects. In the South Italy study, changes in platelet TxB2 production were observed only after return to the original diet in male subjects. Total and LDL cholesterol were significantly increased during the dietary intervention and returned toward baseline levels after switch back to the original diet. These data indicate that the increase of the P/S ratio in the diet reduces platelet TxB2 formation only in men. |
author2 |
E. Tremoli A. Petroni A. Socini P. Maderna S. Colli R. Paoletti C. Galli A. Ferro-Luzzi P. Strazzullo M. Mancini |
format |
Article in Journal/Newspaper |
author |
E. Tremoli A. Petroni S. Colli R. Paoletti C. Galli A. Socini P. Maderna A. Ferro Luzzi P. Strazzullo M. Mancini |
author_facet |
E. Tremoli A. Petroni S. Colli R. Paoletti C. Galli A. Socini P. Maderna A. Ferro Luzzi P. Strazzullo M. Mancini |
author_sort |
E. Tremoli |
title |
Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only |
title_short |
Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only |
title_full |
Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only |
title_fullStr |
Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only |
title_full_unstemmed |
Dietary interventions in north Karelia, Finland and south Italy. Modification of thromboxane B2 formation in platelets of male subjects only |
title_sort |
dietary interventions in north karelia, finland and south italy. modification of thromboxane b2 formation in platelets of male subjects only |
publisher |
Elsevier |
publishDate |
1986 |
url |
http://hdl.handle.net/2434/188712 https://doi.org/10.1016/0021-9150(86)90038-9 |
genre |
karelia* |
genre_facet |
karelia* |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/3964338 info:eu-repo/semantics/altIdentifier/wos/WOS:A1986A393100001 volume:59 issue:2 firstpage:101 lastpage:111 journal:ATHEROSCLEROSIS http://hdl.handle.net/2434/188712 doi:10.1016/0021-9150(86)90038-9 info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-0022638750 |
op_doi |
https://doi.org/10.1016/0021-9150(86)90038-9 |
container_title |
Atherosclerosis |
container_volume |
59 |
container_issue |
2 |
container_start_page |
101 |
op_container_end_page |
111 |
_version_ |
1790602455224942592 |