Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus)
Partial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund. For echolocating bats, hearing is essential for survival. Specializations for detecting and processing high frequency sounds are apparent throughout their auditory systems. Recent studies on echolocating...
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ftunivmaryland:oai:drum.lib.umd.edu:1903/20690 2023-05-15T18:33:31+02:00 Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus) Mao, Beatrice Moss, Cynthia F. Wilkinson, Gerald S. 2017-10-26 application/pdf http://hdl.handle.net/1903/20690 https://doi.org/10.13016/M2610VV88 en_US eng PLoS (Public Library of Science) College of Computer, Mathematical & Physical Sciences Digital Repository at the University of Maryland Biology University of Maryland (College Park, MD) https://doi.org/10.13016/M2610VV88 Mao B, Moss CF, Wilkinson GS (2017) Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus). PLoS ONE 12 (10): e0186667. https://doi.org/10.1371/journal. pone.0186667 http://hdl.handle.net/1903/20690 Article 2017 ftunivmaryland https://doi.org/10.13016/M2610VV88 https://doi.org/10.1371/journal 2022-11-11T11:10:29Z Partial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund. For echolocating bats, hearing is essential for survival. Specializations for detecting and processing high frequency sounds are apparent throughout their auditory systems. Recent studies on echolocating mammals have reported evidence of parallel evolution in some hearing-related genes in which distantly related groups of echolocating animals (bats and toothed whales), cluster together in gene trees due to apparent amino acid convergence. However, molecular adaptations can occur not only in coding sequences, but also in the regulation of gene expression. The aim of this study was to examine the expression of hearingrelated genes in the inner ear of developing big brown bats, Eptesicus fuscus, during the period in which echolocation vocalizations increase dramatically in frequency. We found that seven genes were significantly upregulated in juveniles relative to adults, and that the expression of four genes through development correlated with estimated age. Compared to available data for mice, it appears that expression of some hearing genes is extended in juvenile bats. These results are consistent with a prolonged growth period required to develop larger cochlea relative to body size, a later maturation of high frequency hearing,mand a greater dependence on high frequency hearing in echolocating bats. Article in Journal/Newspaper toothed whales University of Maryland: Digital Repository (DRUM) |
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University of Maryland: Digital Repository (DRUM) |
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ftunivmaryland |
language |
English |
description |
Partial funding for Open Access provided by the UMD Libraries' Open Access Publishing Fund. For echolocating bats, hearing is essential for survival. Specializations for detecting and processing high frequency sounds are apparent throughout their auditory systems. Recent studies on echolocating mammals have reported evidence of parallel evolution in some hearing-related genes in which distantly related groups of echolocating animals (bats and toothed whales), cluster together in gene trees due to apparent amino acid convergence. However, molecular adaptations can occur not only in coding sequences, but also in the regulation of gene expression. The aim of this study was to examine the expression of hearingrelated genes in the inner ear of developing big brown bats, Eptesicus fuscus, during the period in which echolocation vocalizations increase dramatically in frequency. We found that seven genes were significantly upregulated in juveniles relative to adults, and that the expression of four genes through development correlated with estimated age. Compared to available data for mice, it appears that expression of some hearing genes is extended in juvenile bats. These results are consistent with a prolonged growth period required to develop larger cochlea relative to body size, a later maturation of high frequency hearing,mand a greater dependence on high frequency hearing in echolocating bats. |
format |
Article in Journal/Newspaper |
author |
Mao, Beatrice Moss, Cynthia F. Wilkinson, Gerald S. |
spellingShingle |
Mao, Beatrice Moss, Cynthia F. Wilkinson, Gerald S. Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus) |
author_facet |
Mao, Beatrice Moss, Cynthia F. Wilkinson, Gerald S. |
author_sort |
Mao, Beatrice |
title |
Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus) |
title_short |
Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus) |
title_full |
Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus) |
title_fullStr |
Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus) |
title_full_unstemmed |
Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus) |
title_sort |
age-dependent gene expression in the inner ear of big brown bats (eptesicus fuscus) |
publisher |
PLoS (Public Library of Science) |
publishDate |
2017 |
url |
http://hdl.handle.net/1903/20690 https://doi.org/10.13016/M2610VV88 |
genre |
toothed whales |
genre_facet |
toothed whales |
op_relation |
College of Computer, Mathematical & Physical Sciences Digital Repository at the University of Maryland Biology University of Maryland (College Park, MD) https://doi.org/10.13016/M2610VV88 Mao B, Moss CF, Wilkinson GS (2017) Age-dependent gene expression in the inner ear of big brown bats (Eptesicus fuscus). PLoS ONE 12 (10): e0186667. https://doi.org/10.1371/journal. pone.0186667 http://hdl.handle.net/1903/20690 |
op_doi |
https://doi.org/10.13016/M2610VV88 https://doi.org/10.1371/journal |
_version_ |
1766218136729681920 |