SINTEZA SAHAROZA PALMITATA V ORGANSKIH TOPILIH

Namen diplomskega dela je bil sintetizirati saharozo palmitat, ki se uporablja v kozmetični, farmacevtski in prehrambeni industriji. Osredotočili smo se na sintezo saharoza palmitata v t-butanolu, vendar smo za primerjavo izvedli tudi sinteze v drugih organskih topilih, kot so etil metil keton, acet...

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Bibliographic Details
Main Author: Bahlen, Maja
Other Authors: Leitgeb, Maja
Format: Bachelor Thesis
Language:Slovenian
Published: M. Bahlen 2011
Subjects:
encimsko katalizirana sinteza
lipaza B iz Candida antarctica
saharoza palmitat
organska topila
t-butanol
enzymatic synthesis
lipase B from Candida antarctica
sucrose palmitate
organic solvents
info:eu-repo/classification/udc/577.15:547.458.2(043.2)
Antarc*
Antarctica
Online Access:https://dk.um.si/IzpisGradiva.php?id=20413
https://dk.um.si/Dokument.php?id=25272&dn=
https://plus.si.cobiss.net/opac7/bib/15835158?lang=sl
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Summary:Namen diplomskega dela je bil sintetizirati saharozo palmitat, ki se uporablja v kozmetični, farmacevtski in prehrambeni industriji. Osredotočili smo se na sintezo saharoza palmitata v t-butanolu, vendar smo za primerjavo izvedli tudi sinteze v drugih organskih topilih, kot so etil metil keton, aceton in tert-amil alkohol. Encimsko katalizirano sintezo saharoza palmitata smo izvedli v mešalnem šaržnem reaktorju pri temperaturi 60 °C. Reakcijo smo katalizirali z imobilizirano lipazo B iz Candida antarctica. Produkt reakcije je bil saharoza mono-, di- in tri-palmitat. Reakcije smo izvedli z različnimi množinskimi razmerji substratov (palmitinska kislina : saharoza). Najvišjo presnovo smo dobili v primeru, ko je bilo množinsko razmerje substratov (palmitinska kislina : saharoza) 10 : 90. The purpose of this study was to synthesize sucrose palmitate used in cosmetics, pharmaceutical and food industries. Our focus was mainly on the synthesis of sucrose palmitate in tert-butanol. For comparison the synthesis of sucrose palmitate in other organic solvents like ethyl methyl ketone, acetone and tert-amil alcohol were also carried out. Enzyme catalyzed synthesis of sucrose palmitate was carried out at 60 °C in a batch stirred reactor. Reactions were catalyzed by immobilized lipase B from Candida antarctica. Product was sucrose mono-, di- and three-palmitate. Reactions were carried out with different molar ratio of substrates (palmitic acid : sucrose). The highest conversion was obtained when molar ratio of substrates was (palmitic acid : sucrose) 10 : 90.

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