Functional Disability to Evaluate the Risk of Arthritis in First-degree Relatives of Patients With Rheumatoid Arthritis
Objective: The events that occur prior to the onset of rheumatoid arthritis (RA) continue to be delineated. We examined the relationship between self-reported joint symptoms, functional disability, and anticitrullinated protein antibody (ACPA) status in a cohort of first-degree relatives (FDR) of pa...
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ftunivmanitoba:oai:mspace.lib.umanitoba.ca:1993/37807 2024-04-28T08:19:11+00:00 Functional Disability to Evaluate the Risk of Arthritis in First-degree Relatives of Patients With Rheumatoid Arthritis Wiens, Dana Liam , O'Neil El-Gabalawy, Hani 2023-11-22T16:55:32Z application/pdf http://hdl.handle.net/1993/37807 eng eng http://hdl.handle.net/1993/37807 open access rheumatoid arthritis bachelor thesis 2023 ftunivmanitoba 2024-04-03T14:01:32Z Objective: The events that occur prior to the onset of rheumatoid arthritis (RA) continue to be delineated. We examined the relationship between self-reported joint symptoms, functional disability, and anticitrullinated protein antibody (ACPA) status in a cohort of first-degree relatives (FDR) of patients with RA who are at risk of future disease development. Methods: We studied a cohort of 607 FDR of First Nations (FN) patients with RA who are at increased risk for future RA development, and analyzed data collected at their enrollment study visit. In parallel, we analyzed data from 279 FN participants with no family history of RA. A subset of FDR developed inflammatory arthritis and we analyzed longitudinal data in this group. Results: The prevalence of joint symptoms and functional disability was higher in FDR compared to non-FDR (all P < 0.001). Difficulty walking (37.3% vs 18.0%) and modified Health Assessment Questionnaire (mHAQ) results were higher in ACPA-positive FDR compared to ACPA-negative FDR, and mHAQ was independently associated with ACPA seropositivity (OR 2.79, 95% CI 1.56 -5.00). Longitudinally, in individuals who developed ACPA-positive RA, ACPA level and mHAQ score were significantly associated (R = 0.45, P < 0.001) in the preclinical period. Conclusion: Compared to population-based controls, FDR have a high burden of joint symptoms and functional disability. Functional disability was most closely associated with ACPA seropositivity in the FDR, suggesting a direct role for ACPA outside of the context of clinically detectable synovitis. HAQ appears to be particularly valuable in the assessment of individuals at risk for future RA development. Bachelor Thesis First Nations MSpace at the University of Manitoba |
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Open Polar |
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MSpace at the University of Manitoba |
op_collection_id |
ftunivmanitoba |
language |
English |
topic |
rheumatoid arthritis |
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rheumatoid arthritis Wiens, Dana Functional Disability to Evaluate the Risk of Arthritis in First-degree Relatives of Patients With Rheumatoid Arthritis |
topic_facet |
rheumatoid arthritis |
description |
Objective: The events that occur prior to the onset of rheumatoid arthritis (RA) continue to be delineated. We examined the relationship between self-reported joint symptoms, functional disability, and anticitrullinated protein antibody (ACPA) status in a cohort of first-degree relatives (FDR) of patients with RA who are at risk of future disease development. Methods: We studied a cohort of 607 FDR of First Nations (FN) patients with RA who are at increased risk for future RA development, and analyzed data collected at their enrollment study visit. In parallel, we analyzed data from 279 FN participants with no family history of RA. A subset of FDR developed inflammatory arthritis and we analyzed longitudinal data in this group. Results: The prevalence of joint symptoms and functional disability was higher in FDR compared to non-FDR (all P < 0.001). Difficulty walking (37.3% vs 18.0%) and modified Health Assessment Questionnaire (mHAQ) results were higher in ACPA-positive FDR compared to ACPA-negative FDR, and mHAQ was independently associated with ACPA seropositivity (OR 2.79, 95% CI 1.56 -5.00). Longitudinally, in individuals who developed ACPA-positive RA, ACPA level and mHAQ score were significantly associated (R = 0.45, P < 0.001) in the preclinical period. Conclusion: Compared to population-based controls, FDR have a high burden of joint symptoms and functional disability. Functional disability was most closely associated with ACPA seropositivity in the FDR, suggesting a direct role for ACPA outside of the context of clinically detectable synovitis. HAQ appears to be particularly valuable in the assessment of individuals at risk for future RA development. |
author2 |
Liam , O'Neil El-Gabalawy, Hani |
format |
Bachelor Thesis |
author |
Wiens, Dana |
author_facet |
Wiens, Dana |
author_sort |
Wiens, Dana |
title |
Functional Disability to Evaluate the Risk of Arthritis in First-degree Relatives of Patients With Rheumatoid Arthritis |
title_short |
Functional Disability to Evaluate the Risk of Arthritis in First-degree Relatives of Patients With Rheumatoid Arthritis |
title_full |
Functional Disability to Evaluate the Risk of Arthritis in First-degree Relatives of Patients With Rheumatoid Arthritis |
title_fullStr |
Functional Disability to Evaluate the Risk of Arthritis in First-degree Relatives of Patients With Rheumatoid Arthritis |
title_full_unstemmed |
Functional Disability to Evaluate the Risk of Arthritis in First-degree Relatives of Patients With Rheumatoid Arthritis |
title_sort |
functional disability to evaluate the risk of arthritis in first-degree relatives of patients with rheumatoid arthritis |
publishDate |
2023 |
url |
http://hdl.handle.net/1993/37807 |
genre |
First Nations |
genre_facet |
First Nations |
op_relation |
http://hdl.handle.net/1993/37807 |
op_rights |
open access |
_version_ |
1797582824857927680 |