Ultrasound assisted lipase catalyzed synthesis of poly-6-hydroxyhexanoate

• Main Authors: Gumel, A.M., Annuar, M.S.M., Heidelberg, T., Chisti, Y.
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: Elsevier 2012
• Subjects: Q Science (General); QD Chemistry; Antarc*; Antarctica
• Online Access: http://eprints.um.edu.my/9634/; http://eprints.um.edu.my/9634/1/00013161_103469.pdf

Ultrasonic irradiation greatly improved the Candida antarctica lipase B mediated ring opening polymerization of e-caprolactone to poly-6-hydroxyhexanoate in the ionic liquid 1-ethyl-3-methylimidazolium tetraflouroborate. Compared to the conventional nonsonicated reaction, sonication improved the monomer conversion by 63% and afforded a polymer product of a narrower molecular weight distribution and a higher degree of crystallinity. Under sonication, the polydispersity index of the product was 1.44 compared to a value of 2.55 for the product of the conventional reaction. With sonication, nearly 75% of the monomer was converted to product, but the conversion was only 16% for the reaction carried out conventionally. Compared to conventional operation, sonication enhanced the rate of polymer propagation by >2-fold and the turnover number of the lipase by >3-fold.