A CDH23 missense variant in Beauceron dogs with non-syndromic deafness

• Published in: Animal Genetics
• Main Authors: Abitbol, Marie, Jagannathan, Vidhya, Lopez, Marie, Courtin, Ambre, Dufaure de Citres, Caroline, Gache, Vincent, Leeb, Tosso
• Other Authors: VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS), Institut NeuroMyoGène (INMG), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Universität Bern = University of Bern = Université de Berne (UNIBE), École nationale vétérinaire d'Alfort (ENVA), Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Société Centrale Canine, Partenaires INRAE, Antagene France, Collaboration internationale
• Format: Article in Journal/Newspaper
• Language: English
• Published: CCSD 2023
• Subjects: Canis lupus familiaris; DFNB12; Usher syndrome; cadherin; canine; hearing loss; [SDV.BA.MVSA]Life Sciences [q-bio]/Animal biology/Veterinary medicine and animal Health; Merle; Canis lupus
• Online Access: https://enva.hal.science/hal-03854349; https://enva.hal.science/hal-03854349v1/document; https://enva.hal.science/hal-03854349v1/file/main.pdf; https://doi.org/10.1111/age.13273

International audience Congenital coat-colour-related deafness is common among certain canine breeds especially those exhibiting extreme white spotting or merle patterning. We identified a non-syndromic deafness in Beauceron dogs characterised by a bilateral hearing loss in puppies that is not linke...