Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice
International audience Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet containing farmed salmon prevents or contributes to ins...
Published in: | PLoS ONE |
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Main Authors: | , , , , , , , , , , , , |
Other Authors: | , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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HAL CCSD
2011
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Subjects: | |
Online Access: | https://hal.inrae.fr/hal-02646935 https://hal.inrae.fr/hal-02646935/document https://hal.inrae.fr/hal-02646935/file/2011_Ibrahim_Plosone_1.pdf https://doi.org/10.1371/journal.pone.0025170 |
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ftunivlyon1:oai:HAL:hal-02646935v1 |
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record_format |
openpolar |
institution |
Open Polar |
collection |
HAL Lyon 1 (University Claude Bernard Lyon 1) |
op_collection_id |
ftunivlyon1 |
language |
English |
topic |
FISH-OIL SUPPLEMENTATION N-3 FATTY-ACIDS IMPAIRED GLUCOSE-TOLERANCE TYPE-2 DIABETES-MELLITUS DIETARY COD PROTEIN SKELETAL-MUSCLES GLYCEMIC CONTROL BLOOD-PRESSURE SERUM-LIPIDS RISK [SDV]Life Sciences [q-bio] |
spellingShingle |
FISH-OIL SUPPLEMENTATION N-3 FATTY-ACIDS IMPAIRED GLUCOSE-TOLERANCE TYPE-2 DIABETES-MELLITUS DIETARY COD PROTEIN SKELETAL-MUSCLES GLYCEMIC CONTROL BLOOD-PRESSURE SERUM-LIPIDS RISK [SDV]Life Sciences [q-bio] Ibrahim, Mohammad Madani Fjaere, Even Lock, Erik-Jan Naville, Danielle Amlund, Heidi Fouilloux-Meugnier, Emmanuelle Battistoni, Brigitte Le Magueresse Froyland, Livar Madsen, Lise Jessen, Niels Lund, Sten Vidal, Hubert Ruzzin, Jérôme Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice |
topic_facet |
FISH-OIL SUPPLEMENTATION N-3 FATTY-ACIDS IMPAIRED GLUCOSE-TOLERANCE TYPE-2 DIABETES-MELLITUS DIETARY COD PROTEIN SKELETAL-MUSCLES GLYCEMIC CONTROL BLOOD-PRESSURE SERUM-LIPIDS RISK [SDV]Life Sciences [q-bio] |
description |
International audience Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet containing farmed salmon prevents or contributes to insulin resistance in mice. Methodology/Principal Findings: Adult male C57BL/6J mice were fed control diet (C), a very high-fat diet without or with farmed Atlantic salmon fillet (VHF and VHF/S, respectively), and Western diet without or with farmed Atlantic salmon fillet (WD and WD/S, respectively). Other mice were fed VHF containing farmed salmon fillet with reduced concentrations of persistent organic pollutants (VHF/S(-POPs)). We assessed body weight gain, fat mass, insulin sensitivity, glucose tolerance, ex vivo muscle glucose uptake, performed histology and immunohistochemistry analysis, and investigated gene and protein expression. In comparison with animals fed VHF and WD, consumption of both VHF/S and WD/S exaggerated insulin resistance, visceral obesity, and glucose intolerance. In addition, the ability of insulin to stimulate Akt phosphorylation and muscle glucose uptake was impaired in mice fed farmed salmon. Relative to VHF/S-fed mice, animals fed VHF/S(-POPs) had less body burdens of POPs, accumulated less visceral fat, and had reduced mRNA levels of TNF alpha as well as macrophage infiltration in adipose tissue. VHF/S(-POPs)-fed mice further exhibited better insulin sensitivity and glucose tolerance than mice fed VHF/S. Conclusions/Significance: Our data indicate that intake of farmed salmon fillet contributes to several metabolic disorders linked to type 2 diabetes and obesity, and suggest a role of POPs in these deleterious effects. Overall, these findings may participate to improve nutritional strategies for the prevention and therapy of insulin resistance. |
author2 |
National Institute of Nutrition and Seafood Research (NIFES) University of Bergen (UiB) University of Copenhagen = Københavns Universitet (UCPH) Mécanisme Moléculaire du Diabète (MMD) Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM) Institut National de la Recherche Agronomique (INRA) Aarhus University Aarhus Dept Biol Research Council of Norway 184783, 204473, 185567 Danish Council for Strategic Research 2101-08-0053 |
format |
Article in Journal/Newspaper |
author |
Ibrahim, Mohammad Madani Fjaere, Even Lock, Erik-Jan Naville, Danielle Amlund, Heidi Fouilloux-Meugnier, Emmanuelle Battistoni, Brigitte Le Magueresse Froyland, Livar Madsen, Lise Jessen, Niels Lund, Sten Vidal, Hubert Ruzzin, Jérôme |
author_facet |
Ibrahim, Mohammad Madani Fjaere, Even Lock, Erik-Jan Naville, Danielle Amlund, Heidi Fouilloux-Meugnier, Emmanuelle Battistoni, Brigitte Le Magueresse Froyland, Livar Madsen, Lise Jessen, Niels Lund, Sten Vidal, Hubert Ruzzin, Jérôme |
author_sort |
Ibrahim, Mohammad Madani |
title |
Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice |
title_short |
Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice |
title_full |
Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice |
title_fullStr |
Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice |
title_full_unstemmed |
Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice |
title_sort |
chronic consumption of farmed salmon containing persistent organic pollutants causes insulin resistance and obesity in mice |
publisher |
HAL CCSD |
publishDate |
2011 |
url |
https://hal.inrae.fr/hal-02646935 https://hal.inrae.fr/hal-02646935/document https://hal.inrae.fr/hal-02646935/file/2011_Ibrahim_Plosone_1.pdf https://doi.org/10.1371/journal.pone.0025170 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_source |
ISSN: 1932-6203 EISSN: 1932-6203 PLoS ONE https://hal.inrae.fr/hal-02646935 PLoS ONE, 2011, 6 (9), ⟨10.1371/journal.pone.0025170⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0025170 info:eu-repo/semantics/altIdentifier/pmid/21966444 hal-02646935 https://hal.inrae.fr/hal-02646935 https://hal.inrae.fr/hal-02646935/document https://hal.inrae.fr/hal-02646935/file/2011_Ibrahim_Plosone_1.pdf doi:10.1371/journal.pone.0025170 PRODINRA: 205490 PUBMED: 21966444 WOS: 000295267100022 |
op_rights |
info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.1371/journal.pone.0025170 |
container_title |
PLoS ONE |
container_volume |
6 |
container_issue |
9 |
container_start_page |
e25170 |
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1790598060319965184 |
spelling |
ftunivlyon1:oai:HAL:hal-02646935v1 2024-02-11T10:02:10+01:00 Chronic Consumption of Farmed Salmon Containing Persistent Organic Pollutants Causes Insulin Resistance and Obesity in Mice Ibrahim, Mohammad Madani Fjaere, Even Lock, Erik-Jan Naville, Danielle Amlund, Heidi Fouilloux-Meugnier, Emmanuelle Battistoni, Brigitte Le Magueresse Froyland, Livar Madsen, Lise Jessen, Niels Lund, Sten Vidal, Hubert Ruzzin, Jérôme National Institute of Nutrition and Seafood Research (NIFES) University of Bergen (UiB) University of Copenhagen = Københavns Universitet (UCPH) Mécanisme Moléculaire du Diabète (MMD) Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National de la Santé et de la Recherche Médicale (INSERM) Institut National de la Recherche Agronomique (INRA) Aarhus University Aarhus Dept Biol Research Council of Norway 184783, 204473, 185567 Danish Council for Strategic Research 2101-08-0053 2011 https://hal.inrae.fr/hal-02646935 https://hal.inrae.fr/hal-02646935/document https://hal.inrae.fr/hal-02646935/file/2011_Ibrahim_Plosone_1.pdf https://doi.org/10.1371/journal.pone.0025170 en eng HAL CCSD Public Library of Science info:eu-repo/semantics/altIdentifier/doi/10.1371/journal.pone.0025170 info:eu-repo/semantics/altIdentifier/pmid/21966444 hal-02646935 https://hal.inrae.fr/hal-02646935 https://hal.inrae.fr/hal-02646935/document https://hal.inrae.fr/hal-02646935/file/2011_Ibrahim_Plosone_1.pdf doi:10.1371/journal.pone.0025170 PRODINRA: 205490 PUBMED: 21966444 WOS: 000295267100022 info:eu-repo/semantics/OpenAccess ISSN: 1932-6203 EISSN: 1932-6203 PLoS ONE https://hal.inrae.fr/hal-02646935 PLoS ONE, 2011, 6 (9), ⟨10.1371/journal.pone.0025170⟩ FISH-OIL SUPPLEMENTATION N-3 FATTY-ACIDS IMPAIRED GLUCOSE-TOLERANCE TYPE-2 DIABETES-MELLITUS DIETARY COD PROTEIN SKELETAL-MUSCLES GLYCEMIC CONTROL BLOOD-PRESSURE SERUM-LIPIDS RISK [SDV]Life Sciences [q-bio] info:eu-repo/semantics/article Journal articles 2011 ftunivlyon1 https://doi.org/10.1371/journal.pone.0025170 2024-01-16T23:47:59Z International audience Background: Dietary interventions are critical in the prevention of metabolic diseases. Yet, the effects of fatty fish consumption on type 2 diabetes remain unclear. The aim of this study was to investigate whether a diet containing farmed salmon prevents or contributes to insulin resistance in mice. Methodology/Principal Findings: Adult male C57BL/6J mice were fed control diet (C), a very high-fat diet without or with farmed Atlantic salmon fillet (VHF and VHF/S, respectively), and Western diet without or with farmed Atlantic salmon fillet (WD and WD/S, respectively). Other mice were fed VHF containing farmed salmon fillet with reduced concentrations of persistent organic pollutants (VHF/S(-POPs)). We assessed body weight gain, fat mass, insulin sensitivity, glucose tolerance, ex vivo muscle glucose uptake, performed histology and immunohistochemistry analysis, and investigated gene and protein expression. In comparison with animals fed VHF and WD, consumption of both VHF/S and WD/S exaggerated insulin resistance, visceral obesity, and glucose intolerance. In addition, the ability of insulin to stimulate Akt phosphorylation and muscle glucose uptake was impaired in mice fed farmed salmon. Relative to VHF/S-fed mice, animals fed VHF/S(-POPs) had less body burdens of POPs, accumulated less visceral fat, and had reduced mRNA levels of TNF alpha as well as macrophage infiltration in adipose tissue. VHF/S(-POPs)-fed mice further exhibited better insulin sensitivity and glucose tolerance than mice fed VHF/S. Conclusions/Significance: Our data indicate that intake of farmed salmon fillet contributes to several metabolic disorders linked to type 2 diabetes and obesity, and suggest a role of POPs in these deleterious effects. Overall, these findings may participate to improve nutritional strategies for the prevention and therapy of insulin resistance. Article in Journal/Newspaper Atlantic salmon HAL Lyon 1 (University Claude Bernard Lyon 1) PLoS ONE 6 9 e25170 |