Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos)
International audience Oxidative stress, which is believed to promote muscle atrophy, has been reported to occurin a few hibernators. However, hibernating bears exhibit ecient energy savings and muscle proteinsparing, despite long-term physical inactivity and fasting. We hypothesized that the regula...
Published in: | Antioxidants |
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Main Authors: | , , , , , , , , , , , , |
Other Authors: | , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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HAL CCSD
2019
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Subjects: | |
Online Access: | https://hal.science/hal-02274540 https://hal.science/hal-02274540/document https://hal.science/hal-02274540/file/antioxidants-08-00334-v2.pdf https://doi.org/10.3390/antiox8090334 |
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ftunivlyon1:oai:HAL:hal-02274540v1 |
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openpolar |
institution |
Open Polar |
collection |
HAL Lyon 1 (University Claude Bernard Lyon 1) |
op_collection_id |
ftunivlyon1 |
language |
English |
topic |
brown bears hibernation oxidative stress skeletal muscle cold response NRF2 [SDE]Environmental Sciences |
spellingShingle |
brown bears hibernation oxidative stress skeletal muscle cold response NRF2 [SDE]Environmental Sciences Chazarin, Blandine Ziemianin, Anna Evans, Alina L. Meugnier, Emmanuelle Loizon, Emmanuelle Chery, Isabelle Arnemo, Jon M. Swenson, Jon E. Gauquelin-Koch, Guillemette Simon, Chantal Blanc, Stéphane Lefai, Etienne Bertile, Fabrice Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
topic_facet |
brown bears hibernation oxidative stress skeletal muscle cold response NRF2 [SDE]Environmental Sciences |
description |
International audience Oxidative stress, which is believed to promote muscle atrophy, has been reported to occurin a few hibernators. However, hibernating bears exhibit ecient energy savings and muscle proteinsparing, despite long-term physical inactivity and fasting. We hypothesized that the regulation ofthe oxidant/antioxidant balance and oxidative stress could favor skeletal muscle maintenance inhibernating brown bears. We showed that increased expressions of cold-inducible proteins CIRBPand RBM3 could favor muscle mass maintenance and alleviate oxidative stress during hibernation.Downregulation of the subunits of the mitochondrial electron transfer chain complexes I, II, and III,and antioxidant enzymes, possibly due to the reduced mitochondrial content, indicated a possiblereduction of the production of reactive oxygen species in the hibernating muscle. Concomitantly, theupregulation of cytosolic antioxidant systems, under the control of the transcription factor NRF2, andthe maintenance of the GSH/GSSG ratio suggested that bear skeletal muscle is not under a significantoxidative insult during hibernation. Accordingly, lower levels of oxidative damage were recorded inhibernating bear skeletal muscles. These results identify mechanisms by which limited oxidativestress may underlie the resistance to skeletal muscle atrophy in hibernatin |
author2 |
Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC) Institut Pluridisciplinaire Hubert Curien (IPHC) Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) Centre National d'Etudes Spatiales Department of Forestry and Wildlife Management Inland Norway University of Applied Sciences Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN) Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon) Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM) Département Ecologie, Physiologie et Ethologie (DEPE-IPHC) Department of Wildlife, Fish and Environmental Studies Swedish University of Agricultural Sciences = Sveriges lantbruksuniversitet (SLU) Faculty of Environmental Sciences and Natural Resource Management Unité de Nutrition Humaine (UNH) Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne 2017-2020 (UCA 2017-2020 ) ANR-16-IDEX-0001,CAP 20-25,CAP 20-25(2016) |
format |
Article in Journal/Newspaper |
author |
Chazarin, Blandine Ziemianin, Anna Evans, Alina L. Meugnier, Emmanuelle Loizon, Emmanuelle Chery, Isabelle Arnemo, Jon M. Swenson, Jon E. Gauquelin-Koch, Guillemette Simon, Chantal Blanc, Stéphane Lefai, Etienne Bertile, Fabrice |
author_facet |
Chazarin, Blandine Ziemianin, Anna Evans, Alina L. Meugnier, Emmanuelle Loizon, Emmanuelle Chery, Isabelle Arnemo, Jon M. Swenson, Jon E. Gauquelin-Koch, Guillemette Simon, Chantal Blanc, Stéphane Lefai, Etienne Bertile, Fabrice |
author_sort |
Chazarin, Blandine |
title |
Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
title_short |
Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
title_full |
Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
title_fullStr |
Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
title_full_unstemmed |
Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) |
title_sort |
limited oxidative stress favors resistance to skeletal muscle atrophy in hibernating brown bears (ursus arctos) |
publisher |
HAL CCSD |
publishDate |
2019 |
url |
https://hal.science/hal-02274540 https://hal.science/hal-02274540/document https://hal.science/hal-02274540/file/antioxidants-08-00334-v2.pdf https://doi.org/10.3390/antiox8090334 |
genre |
Ursus arctos |
genre_facet |
Ursus arctos |
op_source |
ISSN: 2076-3921 EISSN: 2076-3921 Antioxidants https://hal.science/hal-02274540 Antioxidants , 2019, 8 (9), pp.334. ⟨10.3390/antiox8090334⟩ |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.3390/antiox8090334 info:eu-repo/semantics/altIdentifier/pmid/31443506 hal-02274540 https://hal.science/hal-02274540 https://hal.science/hal-02274540/document https://hal.science/hal-02274540/file/antioxidants-08-00334-v2.pdf doi:10.3390/antiox8090334 PRODINRA: 482908 PUBMED: 31443506 WOS: 000487957300086 |
op_rights |
http://creativecommons.org/licenses/by/ info:eu-repo/semantics/OpenAccess |
op_doi |
https://doi.org/10.3390/antiox8090334 |
container_title |
Antioxidants |
container_volume |
8 |
container_issue |
9 |
container_start_page |
334 |
_version_ |
1796299066273955840 |
spelling |
ftunivlyon1:oai:HAL:hal-02274540v1 2024-04-14T08:20:41+00:00 Limited Oxidative Stress Favors Resistance to Skeletal Muscle Atrophy in Hibernating Brown Bears (Ursus Arctos) Chazarin, Blandine Ziemianin, Anna Evans, Alina L. Meugnier, Emmanuelle Loizon, Emmanuelle Chery, Isabelle Arnemo, Jon M. Swenson, Jon E. Gauquelin-Koch, Guillemette Simon, Chantal Blanc, Stéphane Lefai, Etienne Bertile, Fabrice Département Sciences Analytiques et Interactions Ioniques et Biomoléculaires (DSA-IPHC) Institut Pluridisciplinaire Hubert Curien (IPHC) Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université de Strasbourg (UNISTRA)-Université de Haute-Alsace (UHA) Mulhouse - Colmar (Université de Haute-Alsace (UHA))-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS) Centre National d'Etudes Spatiales Department of Forestry and Wildlife Management Inland Norway University of Applied Sciences Cardiovasculaire, métabolisme, diabétologie et nutrition (CarMeN) Institut National de la Recherche Agronomique (INRA)-Université Claude Bernard Lyon 1 (UCBL) Université de Lyon-Université de Lyon-Institut National des Sciences Appliquées de Lyon (INSA Lyon) Université de Lyon-Institut National des Sciences Appliquées (INSA)-Institut National des Sciences Appliquées (INSA)-Hospices Civils de Lyon (HCL)-Institut National de la Santé et de la Recherche Médicale (INSERM) Département Ecologie, Physiologie et Ethologie (DEPE-IPHC) Department of Wildlife, Fish and Environmental Studies Swedish University of Agricultural Sciences = Sveriges lantbruksuniversitet (SLU) Faculty of Environmental Sciences and Natural Resource Management Unité de Nutrition Humaine (UNH) Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne 2017-2020 (UCA 2017-2020 ) ANR-16-IDEX-0001,CAP 20-25,CAP 20-25(2016) 2019 https://hal.science/hal-02274540 https://hal.science/hal-02274540/document https://hal.science/hal-02274540/file/antioxidants-08-00334-v2.pdf https://doi.org/10.3390/antiox8090334 en eng HAL CCSD MDPI info:eu-repo/semantics/altIdentifier/doi/10.3390/antiox8090334 info:eu-repo/semantics/altIdentifier/pmid/31443506 hal-02274540 https://hal.science/hal-02274540 https://hal.science/hal-02274540/document https://hal.science/hal-02274540/file/antioxidants-08-00334-v2.pdf doi:10.3390/antiox8090334 PRODINRA: 482908 PUBMED: 31443506 WOS: 000487957300086 http://creativecommons.org/licenses/by/ info:eu-repo/semantics/OpenAccess ISSN: 2076-3921 EISSN: 2076-3921 Antioxidants https://hal.science/hal-02274540 Antioxidants , 2019, 8 (9), pp.334. ⟨10.3390/antiox8090334⟩ brown bears hibernation oxidative stress skeletal muscle cold response NRF2 [SDE]Environmental Sciences info:eu-repo/semantics/article Journal articles 2019 ftunivlyon1 https://doi.org/10.3390/antiox8090334 2024-03-21T03:33:38Z International audience Oxidative stress, which is believed to promote muscle atrophy, has been reported to occurin a few hibernators. However, hibernating bears exhibit ecient energy savings and muscle proteinsparing, despite long-term physical inactivity and fasting. We hypothesized that the regulation ofthe oxidant/antioxidant balance and oxidative stress could favor skeletal muscle maintenance inhibernating brown bears. We showed that increased expressions of cold-inducible proteins CIRBPand RBM3 could favor muscle mass maintenance and alleviate oxidative stress during hibernation.Downregulation of the subunits of the mitochondrial electron transfer chain complexes I, II, and III,and antioxidant enzymes, possibly due to the reduced mitochondrial content, indicated a possiblereduction of the production of reactive oxygen species in the hibernating muscle. Concomitantly, theupregulation of cytosolic antioxidant systems, under the control of the transcription factor NRF2, andthe maintenance of the GSH/GSSG ratio suggested that bear skeletal muscle is not under a significantoxidative insult during hibernation. Accordingly, lower levels of oxidative damage were recorded inhibernating bear skeletal muscles. These results identify mechanisms by which limited oxidativestress may underlie the resistance to skeletal muscle atrophy in hibernatin Article in Journal/Newspaper Ursus arctos HAL Lyon 1 (University Claude Bernard Lyon 1) Antioxidants 8 9 334 |