Do commonly used frailty models predict mortality, loss of autonomy and mental decline in older adults in northwestern Russia? A prospective cohort study.
BACKGROUND: Frailty prevalence differs across countries depending on the models used to assess it that are based on various conceptual and operational definitions. This study aims to assess the clinical validity of three frailty models among community-dwelling older adults in north-western Russia wh...
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2016
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Online Access: | http://hdl.handle.net/2078.1/173923 https://doi.org/10.1186/s12877-016-0276-4 |
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ftunivlouvain:oai:dial.uclouvain.be:boreal:173923 2024-05-12T08:08:39+00:00 Do commonly used frailty models predict mortality, loss of autonomy and mental decline in older adults in northwestern Russia? A prospective cohort study. Turusheva, Anna Frolova, Elena Korystina, Elena Zelenukha, Dmitry Tadjibaev, Pulodjon Gurina, Natalia Hegendörfer, Eralda Degryse, Jean-Marie UCL - SSS/IRSS - Institut de recherche santé et société 2016 http://hdl.handle.net/2078.1/173923 https://doi.org/10.1186/s12877-016-0276-4 eng eng BioMed Central Ltd. boreal:173923 http://hdl.handle.net/2078.1/173923 doi:10.1186/s12877-016-0276-4 info:pmid/27160275 urn:EISSN:1471-2318 info:eu-repo/semantics/openAccess BMC Geriatrics, Vol. 16, no. 1, p. 98 [1-13] (2016) Dependency Disability Frailty Mortality Russia info:eu-repo/semantics/article 2016 ftunivlouvain https://doi.org/10.1186/s12877-016-0276-4 2024-04-17T17:04:14Z BACKGROUND: Frailty prevalence differs across countries depending on the models used to assess it that are based on various conceptual and operational definitions. This study aims to assess the clinical validity of three frailty models among community-dwelling older adults in north-western Russia where there is a higher incidence of cardiovascular disease and lower life expectancy than in European countries. METHODS: The Crystal study is a population-based prospective cohort study in Kolpino, St. Petersburg, Russia. A random sample of the population living in the district was stratified into two age groups: 65-75 (n = 305) and 75+ (n = 306) and had a baseline comprehensive health assessment followed by a second one after 33.4 +/-3 months. The total observation time was 47 +/-14.6 months. Frailty was assessed according to the models of Fried, Puts and Steverink-Slaets. Its association with mortality at 5 years follow-up as well as dependency, mental and physical decline at around 2.5 years follow up was explored by multivariable and time-to-event analyses. RESULTS: Mortality was predicted independently from age, sex and comorbidities only by the frail status of the Fried model in those over 75 years old [HR (95 % CI) = 2.50 (1.20-5.20)]. Mental decline was independently predicted only by pre-frail [OR (95 % CI) = 0.24 (0.10-0.55)] and frail [OR (95 % CI) = 0.196 (0.06-0.67)] status of Fried model in those 65-75 years old. The prediction of dependency and physical decline by pre-frail and frail status of any the three frailty models was not statistically significant in this cohort of older adults. CONCLUSIONS: None of the three frailty models was valid at predicting 5 years mortality and disability, mental and physical decline at 2.5 years in a cohort of older adults in north-west Russia. Frailty by the Fried model had only limited value for mortality in those 75 years old and mental decline in those 65-75 years old. Further research is needed to identify valid frailty markers for older adults in this population. Article in Journal/Newspaper North-West Russia North-Western Russia DIAL@UCLouvain (Université catholique de Louvain) BMC Geriatrics 16 1 |
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Open Polar |
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DIAL@UCLouvain (Université catholique de Louvain) |
op_collection_id |
ftunivlouvain |
language |
English |
topic |
Dependency Disability Frailty Mortality Russia |
spellingShingle |
Dependency Disability Frailty Mortality Russia Turusheva, Anna Frolova, Elena Korystina, Elena Zelenukha, Dmitry Tadjibaev, Pulodjon Gurina, Natalia Hegendörfer, Eralda Degryse, Jean-Marie Do commonly used frailty models predict mortality, loss of autonomy and mental decline in older adults in northwestern Russia? A prospective cohort study. |
topic_facet |
Dependency Disability Frailty Mortality Russia |
description |
BACKGROUND: Frailty prevalence differs across countries depending on the models used to assess it that are based on various conceptual and operational definitions. This study aims to assess the clinical validity of three frailty models among community-dwelling older adults in north-western Russia where there is a higher incidence of cardiovascular disease and lower life expectancy than in European countries. METHODS: The Crystal study is a population-based prospective cohort study in Kolpino, St. Petersburg, Russia. A random sample of the population living in the district was stratified into two age groups: 65-75 (n = 305) and 75+ (n = 306) and had a baseline comprehensive health assessment followed by a second one after 33.4 +/-3 months. The total observation time was 47 +/-14.6 months. Frailty was assessed according to the models of Fried, Puts and Steverink-Slaets. Its association with mortality at 5 years follow-up as well as dependency, mental and physical decline at around 2.5 years follow up was explored by multivariable and time-to-event analyses. RESULTS: Mortality was predicted independently from age, sex and comorbidities only by the frail status of the Fried model in those over 75 years old [HR (95 % CI) = 2.50 (1.20-5.20)]. Mental decline was independently predicted only by pre-frail [OR (95 % CI) = 0.24 (0.10-0.55)] and frail [OR (95 % CI) = 0.196 (0.06-0.67)] status of Fried model in those 65-75 years old. The prediction of dependency and physical decline by pre-frail and frail status of any the three frailty models was not statistically significant in this cohort of older adults. CONCLUSIONS: None of the three frailty models was valid at predicting 5 years mortality and disability, mental and physical decline at 2.5 years in a cohort of older adults in north-west Russia. Frailty by the Fried model had only limited value for mortality in those 75 years old and mental decline in those 65-75 years old. Further research is needed to identify valid frailty markers for older adults in this population. |
author2 |
UCL - SSS/IRSS - Institut de recherche santé et société |
format |
Article in Journal/Newspaper |
author |
Turusheva, Anna Frolova, Elena Korystina, Elena Zelenukha, Dmitry Tadjibaev, Pulodjon Gurina, Natalia Hegendörfer, Eralda Degryse, Jean-Marie |
author_facet |
Turusheva, Anna Frolova, Elena Korystina, Elena Zelenukha, Dmitry Tadjibaev, Pulodjon Gurina, Natalia Hegendörfer, Eralda Degryse, Jean-Marie |
author_sort |
Turusheva, Anna |
title |
Do commonly used frailty models predict mortality, loss of autonomy and mental decline in older adults in northwestern Russia? A prospective cohort study. |
title_short |
Do commonly used frailty models predict mortality, loss of autonomy and mental decline in older adults in northwestern Russia? A prospective cohort study. |
title_full |
Do commonly used frailty models predict mortality, loss of autonomy and mental decline in older adults in northwestern Russia? A prospective cohort study. |
title_fullStr |
Do commonly used frailty models predict mortality, loss of autonomy and mental decline in older adults in northwestern Russia? A prospective cohort study. |
title_full_unstemmed |
Do commonly used frailty models predict mortality, loss of autonomy and mental decline in older adults in northwestern Russia? A prospective cohort study. |
title_sort |
do commonly used frailty models predict mortality, loss of autonomy and mental decline in older adults in northwestern russia? a prospective cohort study. |
publisher |
BioMed Central Ltd. |
publishDate |
2016 |
url |
http://hdl.handle.net/2078.1/173923 https://doi.org/10.1186/s12877-016-0276-4 |
genre |
North-West Russia North-Western Russia |
genre_facet |
North-West Russia North-Western Russia |
op_source |
BMC Geriatrics, Vol. 16, no. 1, p. 98 [1-13] (2016) |
op_relation |
boreal:173923 http://hdl.handle.net/2078.1/173923 doi:10.1186/s12877-016-0276-4 info:pmid/27160275 urn:EISSN:1471-2318 |
op_rights |
info:eu-repo/semantics/openAccess |
op_doi |
https://doi.org/10.1186/s12877-016-0276-4 |
container_title |
BMC Geriatrics |
container_volume |
16 |
container_issue |
1 |
_version_ |
1798851747775512576 |