Grey wolf genomic history reveals a dual ancestry of dogs
The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when an...
Published in: | Nature |
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Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
Format: | Article in Journal/Newspaper |
Language: | English |
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Springer Science and Business Media LLC
2022
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Online Access: | http://livrepository.liverpool.ac.uk/3159202/ https://doi.org/10.1038/s41586-022-04824-9 http://livrepository.liverpool.ac.uk/3159202/1/Grey%20wolf%20genomic%20history%20reveals%20a%20dual%20ancestry%20of%20dogs.pdf |
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English |
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The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived 1-8 . Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000-30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located. |
format |
Article in Journal/Newspaper |
author |
Bergstrom, Anders Stanton, David WG Taron, Ulrike H Frantz, Laurent Sinding, Mikkel-Holger S Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophelie Girdland-Flink, Linus Fernandes, Daniel M Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V Ramos-Madrigal, Jazmin Feuerborn, Tatiana R Reiter, Ella Gretzinger, Joscha Muenzel, Susanne C Swali, Pooja Conard, Nicholas J Caroe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Herve Brace, Selina Carden, Ruth F Drucker, Dorothee G Fedorov, Sergey Gasparik, Mihaly Germonpre, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T Ivanova, Varvara V Janssens, Luc Jennings, Richard P Kasparov, Aleksei K Kirillova, Irina V Kurmaniyazov, Islam Kuzmin, Yaroslav V Kosintsev, Pavel A Laznickova-Galetova, Martina Leduc, Charlotte Nikolskiy, Pavel |
spellingShingle |
Bergstrom, Anders Stanton, David WG Taron, Ulrike H Frantz, Laurent Sinding, Mikkel-Holger S Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophelie Girdland-Flink, Linus Fernandes, Daniel M Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V Ramos-Madrigal, Jazmin Feuerborn, Tatiana R Reiter, Ella Gretzinger, Joscha Muenzel, Susanne C Swali, Pooja Conard, Nicholas J Caroe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Herve Brace, Selina Carden, Ruth F Drucker, Dorothee G Fedorov, Sergey Gasparik, Mihaly Germonpre, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T Ivanova, Varvara V Janssens, Luc Jennings, Richard P Kasparov, Aleksei K Kirillova, Irina V Kurmaniyazov, Islam Kuzmin, Yaroslav V Kosintsev, Pavel A Laznickova-Galetova, Martina Leduc, Charlotte Nikolskiy, Pavel Grey wolf genomic history reveals a dual ancestry of dogs |
author_facet |
Bergstrom, Anders Stanton, David WG Taron, Ulrike H Frantz, Laurent Sinding, Mikkel-Holger S Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophelie Girdland-Flink, Linus Fernandes, Daniel M Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V Ramos-Madrigal, Jazmin Feuerborn, Tatiana R Reiter, Ella Gretzinger, Joscha Muenzel, Susanne C Swali, Pooja Conard, Nicholas J Caroe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Herve Brace, Selina Carden, Ruth F Drucker, Dorothee G Fedorov, Sergey Gasparik, Mihaly Germonpre, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T Ivanova, Varvara V Janssens, Luc Jennings, Richard P Kasparov, Aleksei K Kirillova, Irina V Kurmaniyazov, Islam Kuzmin, Yaroslav V Kosintsev, Pavel A Laznickova-Galetova, Martina Leduc, Charlotte Nikolskiy, Pavel |
author_sort |
Bergstrom, Anders |
title |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_short |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_full |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_fullStr |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_full_unstemmed |
Grey wolf genomic history reveals a dual ancestry of dogs |
title_sort |
grey wolf genomic history reveals a dual ancestry of dogs |
publisher |
Springer Science and Business Media LLC |
publishDate |
2022 |
url |
http://livrepository.liverpool.ac.uk/3159202/ https://doi.org/10.1038/s41586-022-04824-9 http://livrepository.liverpool.ac.uk/3159202/1/Grey%20wolf%20genomic%20history%20reveals%20a%20dual%20ancestry%20of%20dogs.pdf |
genre |
Canis lupus Siberia |
genre_facet |
Canis lupus Siberia |
op_relation |
http://livrepository.liverpool.ac.uk/3159202/1/Grey%20wolf%20genomic%20history%20reveals%20a%20dual%20ancestry%20of%20dogs.pdf Collapse authors list. Bergstrom, Anders, Stanton, David WG, Taron, Ulrike H, Frantz, Laurent, Sinding, Mikkel-Holger S, Ersmark, Erik, Pfrengle, Saskia, Cassatt-Johnstone, Molly, Lebrasseur, Ophelie orcid:0000-0003-0687-8538 , Girdland-Flink, Linus et al (show 71 more authors) , Fernandes, Daniel M, Ollivier, Morgane, Speidel, Leo, Gopalakrishnan, Shyam, Westbury, Michael V, Ramos-Madrigal, Jazmin, Feuerborn, Tatiana R, Reiter, Ella, Gretzinger, Joscha, Muenzel, Susanne C, Swali, Pooja, Conard, Nicholas J, Caroe, Christian, Haile, James, Linderholm, Anna, Androsov, Semyon, Barnes, Ian, Baumann, Chris, Benecke, Norbert, Bocherens, Herve, Brace, Selina, Carden, Ruth F, Drucker, Dorothee G, Fedorov, Sergey, Gasparik, Mihaly, Germonpre, Mietje, Grigoriev, Semyon, Groves, Pam, Hertwig, Stefan T, Ivanova, Varvara V, Janssens, Luc, Jennings, Richard P, Kasparov, Aleksei K, Kirillova, Irina V, Kurmaniyazov, Islam, Kuzmin, Yaroslav V, Kosintsev, Pavel A, Laznickova-Galetova, Martina, Leduc, Charlotte, Nikolskiy, Pavel, Nussbaumer, Marc, O'Drisceoil, Coilin, Orlando, Ludovic, Outram, Alan, Pavlova, Elena Y, Perri, Angela R, Pilot, Malgorzata, Pitulko, Vladimir V, Plotnikov, Valerii V, Protopopov, Albert V, Rehazek, Andre, Sablin, Mikhail, Seguin-Orlando, Andaine, Stora, Jan, Verjux, Christian, Zaibert, Victor F, Zazula, Grant, Crombe, Philippe, Hansen, Anders J, Willerslev, Eske, Leonard, Jennifer A, Gotherstrom, Anders, Pinhasi, Ron, Schuenemann, Verena J, Hofreiter, Michael, Gilbert, M Thomas P, Shapiro, Beth, Larson, Greger, Krause, Johannes, Dalen, Love and Skoglund, Pontus (2022) Grey wolf genomic history reveals a dual ancestry of dogs. NATURE, 607 (7918). 313-+. |
op_doi |
https://doi.org/10.1038/s41586-022-04824-9 |
container_title |
Nature |
container_volume |
607 |
container_issue |
7918 |
container_start_page |
313 |
op_container_end_page |
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ftunivliverpool:oai:livrepository.liverpool.ac.uk:3159202 2023-05-15T15:50:39+02:00 Grey wolf genomic history reveals a dual ancestry of dogs Bergstrom, Anders Stanton, David WG Taron, Ulrike H Frantz, Laurent Sinding, Mikkel-Holger S Ersmark, Erik Pfrengle, Saskia Cassatt-Johnstone, Molly Lebrasseur, Ophelie Girdland-Flink, Linus Fernandes, Daniel M Ollivier, Morgane Speidel, Leo Gopalakrishnan, Shyam Westbury, Michael V Ramos-Madrigal, Jazmin Feuerborn, Tatiana R Reiter, Ella Gretzinger, Joscha Muenzel, Susanne C Swali, Pooja Conard, Nicholas J Caroe, Christian Haile, James Linderholm, Anna Androsov, Semyon Barnes, Ian Baumann, Chris Benecke, Norbert Bocherens, Herve Brace, Selina Carden, Ruth F Drucker, Dorothee G Fedorov, Sergey Gasparik, Mihaly Germonpre, Mietje Grigoriev, Semyon Groves, Pam Hertwig, Stefan T Ivanova, Varvara V Janssens, Luc Jennings, Richard P Kasparov, Aleksei K Kirillova, Irina V Kurmaniyazov, Islam Kuzmin, Yaroslav V Kosintsev, Pavel A Laznickova-Galetova, Martina Leduc, Charlotte Nikolskiy, Pavel 2022 text http://livrepository.liverpool.ac.uk/3159202/ https://doi.org/10.1038/s41586-022-04824-9 http://livrepository.liverpool.ac.uk/3159202/1/Grey%20wolf%20genomic%20history%20reveals%20a%20dual%20ancestry%20of%20dogs.pdf en eng eng Springer Science and Business Media LLC http://livrepository.liverpool.ac.uk/3159202/1/Grey%20wolf%20genomic%20history%20reveals%20a%20dual%20ancestry%20of%20dogs.pdf Collapse authors list. Bergstrom, Anders, Stanton, David WG, Taron, Ulrike H, Frantz, Laurent, Sinding, Mikkel-Holger S, Ersmark, Erik, Pfrengle, Saskia, Cassatt-Johnstone, Molly, Lebrasseur, Ophelie orcid:0000-0003-0687-8538 , Girdland-Flink, Linus et al (show 71 more authors) , Fernandes, Daniel M, Ollivier, Morgane, Speidel, Leo, Gopalakrishnan, Shyam, Westbury, Michael V, Ramos-Madrigal, Jazmin, Feuerborn, Tatiana R, Reiter, Ella, Gretzinger, Joscha, Muenzel, Susanne C, Swali, Pooja, Conard, Nicholas J, Caroe, Christian, Haile, James, Linderholm, Anna, Androsov, Semyon, Barnes, Ian, Baumann, Chris, Benecke, Norbert, Bocherens, Herve, Brace, Selina, Carden, Ruth F, Drucker, Dorothee G, Fedorov, Sergey, Gasparik, Mihaly, Germonpre, Mietje, Grigoriev, Semyon, Groves, Pam, Hertwig, Stefan T, Ivanova, Varvara V, Janssens, Luc, Jennings, Richard P, Kasparov, Aleksei K, Kirillova, Irina V, Kurmaniyazov, Islam, Kuzmin, Yaroslav V, Kosintsev, Pavel A, Laznickova-Galetova, Martina, Leduc, Charlotte, Nikolskiy, Pavel, Nussbaumer, Marc, O'Drisceoil, Coilin, Orlando, Ludovic, Outram, Alan, Pavlova, Elena Y, Perri, Angela R, Pilot, Malgorzata, Pitulko, Vladimir V, Plotnikov, Valerii V, Protopopov, Albert V, Rehazek, Andre, Sablin, Mikhail, Seguin-Orlando, Andaine, Stora, Jan, Verjux, Christian, Zaibert, Victor F, Zazula, Grant, Crombe, Philippe, Hansen, Anders J, Willerslev, Eske, Leonard, Jennifer A, Gotherstrom, Anders, Pinhasi, Ron, Schuenemann, Verena J, Hofreiter, Michael, Gilbert, M Thomas P, Shapiro, Beth, Larson, Greger, Krause, Johannes, Dalen, Love and Skoglund, Pontus (2022) Grey wolf genomic history reveals a dual ancestry of dogs. NATURE, 607 (7918). 313-+. Article NonPeerReviewed 2022 ftunivliverpool https://doi.org/10.1038/s41586-022-04824-9 2023-01-20T00:17:49Z The grey wolf (Canis lupus) was the first species to give rise to a domestic population, and they remained widespread throughout the last Ice Age when many other large mammal species went extinct. Little is known, however, about the history and possible extinction of past wolf populations or when and where the wolf progenitors of the present-day dog lineage (Canis familiaris) lived 1-8 . Here we analysed 72 ancient wolf genomes spanning the last 100,000 years from Europe, Siberia and North America. We found that wolf populations were highly connected throughout the Late Pleistocene, with levels of differentiation an order of magnitude lower than they are today. This population connectivity allowed us to detect natural selection across the time series, including rapid fixation of mutations in the gene IFT88 40,000-30,000 years ago. We show that dogs are overall more closely related to ancient wolves from eastern Eurasia than to those from western Eurasia, suggesting a domestication process in the east. However, we also found that dogs in the Near East and Africa derive up to half of their ancestry from a distinct population related to modern southwest Eurasian wolves, reflecting either an independent domestication process or admixture from local wolves. None of the analysed ancient wolf genomes is a direct match for either of these dog ancestries, meaning that the exact progenitor populations remain to be located. Article in Journal/Newspaper Canis lupus Siberia The University of Liverpool Repository Nature 607 7918 313 320 |