A scan for genes associated with cancer mortality and longevity in pedigree dog breeds.
Selective breeding of the domestic dog (Canis lupus familiaris) rigidly retains desirable features, and could inadvertently fix disease-causing variants within a breed. We combine phenotypic data from > 72,000 dogs with a large genotypic dataset to search for genes associated with cancer mortalit...
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Online Access: | http://livrepository.liverpool.ac.uk/3094343/ https://link.springer.com/article/10.1007%2Fs00335-020-09845-1 http://livrepository.liverpool.ac.uk/3094343/1/Doherty2020_inpress.pdf |
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ftunivliverpool:oai:livrepository.liverpool.ac.uk:3094343 2023-05-15T15:50:33+02:00 A scan for genes associated with cancer mortality and longevity in pedigree dog breeds. Doherty, Aoife Lopes, Inês Ford, Christopher T Monaco, Gianni Guest, Patrick de Magalhães, João Pedro 2020-07-13 text http://livrepository.liverpool.ac.uk/3094343/ https://link.springer.com/article/10.1007%2Fs00335-020-09845-1 http://livrepository.liverpool.ac.uk/3094343/1/Doherty2020_inpress.pdf en eng eng Springer http://livrepository.liverpool.ac.uk/3094343/1/Doherty2020_inpress.pdf Doherty, Aoife, Lopes, Inês, Ford, Christopher T, Monaco, Gianni, Guest, Patrick and de Magalhães, João Pedro orcid:0000-0002-6363-2465 (2020) A scan for genes associated with cancer mortality and longevity in pedigree dog breeds. Mammalian genome : official journal of the International Mammalian Genome Society, 31 (7-8). pp. 215-227. Article NonPeerReviewed 2020 ftunivliverpool 2023-01-19T23:55:50Z Selective breeding of the domestic dog (Canis lupus familiaris) rigidly retains desirable features, and could inadvertently fix disease-causing variants within a breed. We combine phenotypic data from > 72,000 dogs with a large genotypic dataset to search for genes associated with cancer mortality and longevity in pedigree dog breeds. We validated previous findings that breeds with higher average body weight have higher cancer mortality rates and lower life expectancy. We identified a significant positive correlation between life span and cancer mortality residuals corrected for body weight, implying that long-lived breeds die more frequently from cancer compared to short-lived breeds. We replicated a number of known genetic associations with body weight (IGF1, GHR, CD36, SMAD2 and IGF2BP2). Subsequently, we identified five genetic variants in known cancer-related genes (located within SIPA1, ADCY7 and ARNT2) that could be associated with cancer mortality residuals corrected for confounding factors. One putative genetic variant was marginally significantly associated with longevity residuals that had been corrected for the effects of body weight; this genetic variant is located within PRDX1, a peroxiredoxin that belongs to an emerging class of pro-longevity associated genes. This research should be considered as an exploratory analysis to uncover associations between genes and longevity/cancer mortality. Article in Journal/Newspaper Canis lupus The University of Liverpool Repository |
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The University of Liverpool Repository |
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language |
English |
description |
Selective breeding of the domestic dog (Canis lupus familiaris) rigidly retains desirable features, and could inadvertently fix disease-causing variants within a breed. We combine phenotypic data from > 72,000 dogs with a large genotypic dataset to search for genes associated with cancer mortality and longevity in pedigree dog breeds. We validated previous findings that breeds with higher average body weight have higher cancer mortality rates and lower life expectancy. We identified a significant positive correlation between life span and cancer mortality residuals corrected for body weight, implying that long-lived breeds die more frequently from cancer compared to short-lived breeds. We replicated a number of known genetic associations with body weight (IGF1, GHR, CD36, SMAD2 and IGF2BP2). Subsequently, we identified five genetic variants in known cancer-related genes (located within SIPA1, ADCY7 and ARNT2) that could be associated with cancer mortality residuals corrected for confounding factors. One putative genetic variant was marginally significantly associated with longevity residuals that had been corrected for the effects of body weight; this genetic variant is located within PRDX1, a peroxiredoxin that belongs to an emerging class of pro-longevity associated genes. This research should be considered as an exploratory analysis to uncover associations between genes and longevity/cancer mortality. |
format |
Article in Journal/Newspaper |
author |
Doherty, Aoife Lopes, Inês Ford, Christopher T Monaco, Gianni Guest, Patrick de Magalhães, João Pedro |
spellingShingle |
Doherty, Aoife Lopes, Inês Ford, Christopher T Monaco, Gianni Guest, Patrick de Magalhães, João Pedro A scan for genes associated with cancer mortality and longevity in pedigree dog breeds. |
author_facet |
Doherty, Aoife Lopes, Inês Ford, Christopher T Monaco, Gianni Guest, Patrick de Magalhães, João Pedro |
author_sort |
Doherty, Aoife |
title |
A scan for genes associated with cancer mortality and longevity in pedigree dog breeds. |
title_short |
A scan for genes associated with cancer mortality and longevity in pedigree dog breeds. |
title_full |
A scan for genes associated with cancer mortality and longevity in pedigree dog breeds. |
title_fullStr |
A scan for genes associated with cancer mortality and longevity in pedigree dog breeds. |
title_full_unstemmed |
A scan for genes associated with cancer mortality and longevity in pedigree dog breeds. |
title_sort |
scan for genes associated with cancer mortality and longevity in pedigree dog breeds. |
publisher |
Springer |
publishDate |
2020 |
url |
http://livrepository.liverpool.ac.uk/3094343/ https://link.springer.com/article/10.1007%2Fs00335-020-09845-1 http://livrepository.liverpool.ac.uk/3094343/1/Doherty2020_inpress.pdf |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
http://livrepository.liverpool.ac.uk/3094343/1/Doherty2020_inpress.pdf Doherty, Aoife, Lopes, Inês, Ford, Christopher T, Monaco, Gianni, Guest, Patrick and de Magalhães, João Pedro orcid:0000-0002-6363-2465 (2020) A scan for genes associated with cancer mortality and longevity in pedigree dog breeds. Mammalian genome : official journal of the International Mammalian Genome Society, 31 (7-8). pp. 215-227. |
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