Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition
Amyloid-β (Aβ) peptides occur in the brains of patients with Alzheimer's disease (AD), but their role in functional impairment is still debated. High levels of APP and APP fragments in mice that overexpress APP might confound their use in preclinical research. We examined the occurrence of beha...
Main Authors: | , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Elsevier Science BV
2017
|
Subjects: | |
Online Access: | https://lirias.kuleuven.be/handle/123456789/601558 https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(17)31710-2 https://lirias.kuleuven.be/bitstream/123456789/601558/1//Hernandez+et+al_Behav+Brain+Res+2017.pdf |
id |
ftunivleuven:oai:lirias.kuleuven.be:123456789/601558 |
---|---|
record_format |
openpolar |
spelling |
ftunivleuven:oai:lirias.kuleuven.be:123456789/601558 2023-05-15T15:07:05+02:00 Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition Hernandez, Amira Latif Shah, Disha Craessaerts, Katleen Saido, Takaomi Saito, Takashi De Strooper, Bart Van der Linden, Annemie D'Hooge, Rudi 2017-11 1639118 bytes application/pdf https://lirias.kuleuven.be/handle/123456789/601558 https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(17)31710-2 https://lirias.kuleuven.be/bitstream/123456789/601558/1//Hernandez+et+al_Behav+Brain+Res+2017.pdf en eng Elsevier Science BV Behavioural Brain Research vol:Ahead of print https://lirias.kuleuven.be/handle/123456789/601558 0166-4328 https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(17)31710-2 1872-7549 https://lirias.kuleuven.be/bitstream/123456789/601558/1//Hernandez+et+al_Behav+Brain+Res+2017.pdf 479291;intranet Article IT 479291;Article 2017 ftunivleuven 2018-01-06T16:27:44Z Amyloid-β (Aβ) peptides occur in the brains of patients with Alzheimer's disease (AD), but their role in functional impairment is still debated. High levels of APP and APP fragments in mice that overexpress APP might confound their use in preclinical research. We examined the occurrence of behavioral, cognitive and neuroimaging changes in APPNL-G-F knock-in mice that display Aβ42 amyloidosis in the absence of APP overexpression. Female APPNL-G-F mice (carrying Swedish, Iberian and Arctic APP mutations) were compared to APPNL mice (APP Swedish) at 3, 7 and 10 months. Mice were subjected to a test battery that referred to clinical AD symptoms, comprising cage activity, open field, elevated plus maze, social preference and novelty test, and spatial learning, reversal learning and spatial reference memory performance. Our assessment confirmed that behavior at these early ages was largely unaffected in these mice in accordance with previous reports, with some subtle behavioral changes, mainly in social and anxiety-related test performance. Resting-state functional MRI (rsfMRI) assessed connectivity between hippocampal and prefrontal regions with an established role in flexibility, learning and memory. Increased prefrontal-hippocampal network synchronicity was found in 3-month-old APPNL-G-F mice. These functional changes occurred before prominent amyloid plaque deposition. status: accepted Article in Journal/Newspaper Arctic KU Leuven: Lirias Arctic |
institution |
Open Polar |
collection |
KU Leuven: Lirias |
op_collection_id |
ftunivleuven |
language |
English |
description |
Amyloid-β (Aβ) peptides occur in the brains of patients with Alzheimer's disease (AD), but their role in functional impairment is still debated. High levels of APP and APP fragments in mice that overexpress APP might confound their use in preclinical research. We examined the occurrence of behavioral, cognitive and neuroimaging changes in APPNL-G-F knock-in mice that display Aβ42 amyloidosis in the absence of APP overexpression. Female APPNL-G-F mice (carrying Swedish, Iberian and Arctic APP mutations) were compared to APPNL mice (APP Swedish) at 3, 7 and 10 months. Mice were subjected to a test battery that referred to clinical AD symptoms, comprising cage activity, open field, elevated plus maze, social preference and novelty test, and spatial learning, reversal learning and spatial reference memory performance. Our assessment confirmed that behavior at these early ages was largely unaffected in these mice in accordance with previous reports, with some subtle behavioral changes, mainly in social and anxiety-related test performance. Resting-state functional MRI (rsfMRI) assessed connectivity between hippocampal and prefrontal regions with an established role in flexibility, learning and memory. Increased prefrontal-hippocampal network synchronicity was found in 3-month-old APPNL-G-F mice. These functional changes occurred before prominent amyloid plaque deposition. status: accepted |
format |
Article in Journal/Newspaper |
author |
Hernandez, Amira Latif Shah, Disha Craessaerts, Katleen Saido, Takaomi Saito, Takashi De Strooper, Bart Van der Linden, Annemie D'Hooge, Rudi |
spellingShingle |
Hernandez, Amira Latif Shah, Disha Craessaerts, Katleen Saido, Takaomi Saito, Takashi De Strooper, Bart Van der Linden, Annemie D'Hooge, Rudi Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition |
author_facet |
Hernandez, Amira Latif Shah, Disha Craessaerts, Katleen Saido, Takaomi Saito, Takashi De Strooper, Bart Van der Linden, Annemie D'Hooge, Rudi |
author_sort |
Hernandez, Amira Latif |
title |
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition |
title_short |
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition |
title_full |
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition |
title_fullStr |
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition |
title_full_unstemmed |
Subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in APPNL-G-F mice before prominent plaque deposition |
title_sort |
subtle behavioral changes and increased prefrontal-hippocampal network synchronicity in appnl-g-f mice before prominent plaque deposition |
publisher |
Elsevier Science BV |
publishDate |
2017 |
url |
https://lirias.kuleuven.be/handle/123456789/601558 https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(17)31710-2 https://lirias.kuleuven.be/bitstream/123456789/601558/1//Hernandez+et+al_Behav+Brain+Res+2017.pdf |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
Behavioural Brain Research vol:Ahead of print https://lirias.kuleuven.be/handle/123456789/601558 0166-4328 https://linkinghub.elsevier.com/retrieve/pii/S0166-4328(17)31710-2 1872-7549 https://lirias.kuleuven.be/bitstream/123456789/601558/1//Hernandez+et+al_Behav+Brain+Res+2017.pdf |
op_rights |
479291;intranet |
_version_ |
1766338647931486208 |