Oximetry in glaucoma: correlation of metabolic change with structural and functional damage
Purpose: To determine whether retinal vessel oxygen saturation in patients with glaucoma is associated with structural optic disc and retinal nerve fibre layer (RNFL) changes and visual field (VF) defects. Methods: Fifty-nine patients with confirmed glaucoma were recruited at University Hospitals Le...
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Online Access: | https://lirias.kuleuven.be/handle/123456789/433008 https://doi.org/10.1111/aos.12011 https://lirias.kuleuven.be/bitstream/123456789/433008/4//Vandewalle_et_al-2014-Acta_Ophthalmologica.pdf |
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ftunivleuven:oai:lirias.kuleuven.be:123456789/433008 2023-05-15T16:51:47+02:00 Oximetry in glaucoma: correlation of metabolic change with structural and functional damage Vandewalle, Evelien Pinto, Luis Olafsdottir, Olof B De Clerck, Eline Stalmans, Peter Van Calster, Joachim Zeyen, Thierry Stefánsson, Einar Stalmans, Ingeborg 2014-03 https://lirias.kuleuven.be/handle/123456789/433008 https://doi.org/10.1111/aos.12011 https://lirias.kuleuven.be/bitstream/123456789/433008/4//Vandewalle_et_al-2014-Acta_Ophthalmologica.pdf en eng Wiley-Blackwell Publishing, Inc Acta Ophthalmologica vol:92 issue:2 pages:105-110 https://lirias.kuleuven.be/handle/123456789/433008 1755-375X http://dx.doi.org/10.1111/aos.12011 1755-3768 https://lirias.kuleuven.be/bitstream/123456789/433008/4//Vandewalle_et_al-2014-Acta_Ophthalmologica.pdf 366248;intranet Article IT 366248;Article 2014 ftunivleuven https://doi.org/10.1111/aos.12011 2017-06-02T19:25:54Z Purpose: To determine whether retinal vessel oxygen saturation in patients with glaucoma is associated with structural optic disc and retinal nerve fibre layer (RNFL) changes and visual field (VF) defects. Methods: Fifty-nine patients with confirmed glaucoma were recruited at University Hospitals Leuven. Retinal oxygen saturation in patients with glaucoma was measured with a noninvasive spectrophotometric retinal oximeter (Oxymap ehf, Reykjavik, Iceland). VF and Heidelberg retinal tomographies (HRTs) were performed on the same day. Statistical analysis was performed using Student's t-test and Pearson's or Spearman correlation coefficient. Results: The mean oxygen saturation in venules was higher in patients with severe VF defects compared to those patients with mild VF defects (69 ± 3% versus 65 ± 6% respectively; p = 0.0003; n = 59). Accordingly, the arteriovenous (AV) difference in oxygen saturation was lower in patients with worse VF compared to those with better VF (29 ± 3% versus 33 ± 6% respectively; p = 0.002). The oxygen saturation in venules correlated with the VF mean defects (r = -0.42; p = 0.001; n = 59) as well as with the structural HRT parameters rim area and RNFL thickness (r = -0.39; p = 0.008 and r = -0.26; p = 0.05 respectively; n = 53). The AV difference decreased significantly as the VF defect worsened (r = 0.38; p = 0.003), as the rim area diminished (r = 0.29; p = 0.03) and as the RNFL thickness decreased (r = 0.27; p = 0.05). No correlation was found between the oxygen saturation in retinal arterioles and either of these parameters. Conclusion: Severe glaucomatous damage is associated with increased oxygen saturation in retinal venules and decreased AV difference in oxygen saturation. These data suggest that in eyes with severe glaucomatous damage, reduced retinal oxygen consumption is consistent with tissue loss. status: published Article in Journal/Newspaper Iceland KU Leuven: Lirias Acta Ophthalmologica 92 2 105 110 |
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Open Polar |
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KU Leuven: Lirias |
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ftunivleuven |
language |
English |
description |
Purpose: To determine whether retinal vessel oxygen saturation in patients with glaucoma is associated with structural optic disc and retinal nerve fibre layer (RNFL) changes and visual field (VF) defects. Methods: Fifty-nine patients with confirmed glaucoma were recruited at University Hospitals Leuven. Retinal oxygen saturation in patients with glaucoma was measured with a noninvasive spectrophotometric retinal oximeter (Oxymap ehf, Reykjavik, Iceland). VF and Heidelberg retinal tomographies (HRTs) were performed on the same day. Statistical analysis was performed using Student's t-test and Pearson's or Spearman correlation coefficient. Results: The mean oxygen saturation in venules was higher in patients with severe VF defects compared to those patients with mild VF defects (69 ± 3% versus 65 ± 6% respectively; p = 0.0003; n = 59). Accordingly, the arteriovenous (AV) difference in oxygen saturation was lower in patients with worse VF compared to those with better VF (29 ± 3% versus 33 ± 6% respectively; p = 0.002). The oxygen saturation in venules correlated with the VF mean defects (r = -0.42; p = 0.001; n = 59) as well as with the structural HRT parameters rim area and RNFL thickness (r = -0.39; p = 0.008 and r = -0.26; p = 0.05 respectively; n = 53). The AV difference decreased significantly as the VF defect worsened (r = 0.38; p = 0.003), as the rim area diminished (r = 0.29; p = 0.03) and as the RNFL thickness decreased (r = 0.27; p = 0.05). No correlation was found between the oxygen saturation in retinal arterioles and either of these parameters. Conclusion: Severe glaucomatous damage is associated with increased oxygen saturation in retinal venules and decreased AV difference in oxygen saturation. These data suggest that in eyes with severe glaucomatous damage, reduced retinal oxygen consumption is consistent with tissue loss. status: published |
format |
Article in Journal/Newspaper |
author |
Vandewalle, Evelien Pinto, Luis Olafsdottir, Olof B De Clerck, Eline Stalmans, Peter Van Calster, Joachim Zeyen, Thierry Stefánsson, Einar Stalmans, Ingeborg |
spellingShingle |
Vandewalle, Evelien Pinto, Luis Olafsdottir, Olof B De Clerck, Eline Stalmans, Peter Van Calster, Joachim Zeyen, Thierry Stefánsson, Einar Stalmans, Ingeborg Oximetry in glaucoma: correlation of metabolic change with structural and functional damage |
author_facet |
Vandewalle, Evelien Pinto, Luis Olafsdottir, Olof B De Clerck, Eline Stalmans, Peter Van Calster, Joachim Zeyen, Thierry Stefánsson, Einar Stalmans, Ingeborg |
author_sort |
Vandewalle, Evelien |
title |
Oximetry in glaucoma: correlation of metabolic change with structural and functional damage |
title_short |
Oximetry in glaucoma: correlation of metabolic change with structural and functional damage |
title_full |
Oximetry in glaucoma: correlation of metabolic change with structural and functional damage |
title_fullStr |
Oximetry in glaucoma: correlation of metabolic change with structural and functional damage |
title_full_unstemmed |
Oximetry in glaucoma: correlation of metabolic change with structural and functional damage |
title_sort |
oximetry in glaucoma: correlation of metabolic change with structural and functional damage |
publisher |
Wiley-Blackwell Publishing, Inc |
publishDate |
2014 |
url |
https://lirias.kuleuven.be/handle/123456789/433008 https://doi.org/10.1111/aos.12011 https://lirias.kuleuven.be/bitstream/123456789/433008/4//Vandewalle_et_al-2014-Acta_Ophthalmologica.pdf |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Acta Ophthalmologica vol:92 issue:2 pages:105-110 https://lirias.kuleuven.be/handle/123456789/433008 1755-375X http://dx.doi.org/10.1111/aos.12011 1755-3768 https://lirias.kuleuven.be/bitstream/123456789/433008/4//Vandewalle_et_al-2014-Acta_Ophthalmologica.pdf |
op_rights |
366248;intranet |
op_doi |
https://doi.org/10.1111/aos.12011 |
container_title |
Acta Ophthalmologica |
container_volume |
92 |
container_issue |
2 |
container_start_page |
105 |
op_container_end_page |
110 |
_version_ |
1766041885884809216 |