Phenylephrine 5% added to Tropicamide 0.5% eye drops does not influence retinal oxygen saturation values or retinal vessel diameter in glaucoma patients
Purpose: To test whether adding topical phenylephrine 5% to tropicamide 0.5% eye drops in the protocol for pupil dilation affects the retinal vessel oximeter measurements in patients with glaucoma. To test whether phenylephrine 5% has an influence as a vasoconstrictor on the retinal vessel width and...
Main Authors: | , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
Wiley-Blackwell Publishing, Inc
2013
|
Subjects: | |
Online Access: | https://lirias.kuleuven.be/handle/123456789/365799 https://lirias.kuleuven.be/bitstream/123456789/365799/3//Phenylephrine+5%25+added+to+Tropicamide+0.5%25+eye+drops+does+not+influence+retinal+oxygen+saturation+values+or+retinal+vessel+diameter+in+glaucoma+patients.pdf |
id |
ftunivleuven:oai:lirias.kuleuven.be:123456789/365799 |
---|---|
record_format |
openpolar |
spelling |
ftunivleuven:oai:lirias.kuleuven.be:123456789/365799 2023-05-15T16:52:29+02:00 Phenylephrine 5% added to Tropicamide 0.5% eye drops does not influence retinal oxygen saturation values or retinal vessel diameter in glaucoma patients Vandewalle, Evelien Abegão Pinto, Luis Olafsdottir, Olof Birna Stalmans, Ingeborg 2013-12 https://lirias.kuleuven.be/handle/123456789/365799 https://lirias.kuleuven.be/bitstream/123456789/365799/3//Phenylephrine+5%25+added+to+Tropicamide+0.5%25+eye+drops+does+not+influence+retinal+oxygen+saturation+values+or+retinal+vessel+diameter+in+glaucoma+patients.pdf en eng Wiley-Blackwell Publishing, Inc Acta Ophthalmologica vol:91 issue:8 pages:733-7 https://lirias.kuleuven.be/handle/123456789/365799 1755-375X 1755-3768 https://lirias.kuleuven.be/bitstream/123456789/365799/3//Phenylephrine+5%25+added+to+Tropicamide+0.5%25+eye+drops+does+not+influence+retinal+oxygen+saturation+values+or+retinal+vessel+diameter+in+glaucoma+patients.pdf 372232;public Article IT 372232;Article 2013 ftunivleuven 2017-09-19T12:11:00Z Purpose: To test whether adding topical phenylephrine 5% to tropicamide 0.5% eye drops in the protocol for pupil dilation affects the retinal vessel oximeter measurements in patients with glaucoma. To test whether phenylephrine 5% has an influence as a vasoconstrictor on the retinal vessel width and can improve the proportion of high-quality retinal images in patients with glaucoma. Methods: Retinal images of 66 patients with chronic open-angle glaucoma were obtained before and after the administration of phenylephrine 5% eye drops to patients already dilated with tropicamide 0.5% with the Oxymap Retinal Oximeter (Oxymap ehf, Reykjavik, Iceland). Specialized software, Oxymap Analyzer, analysed the images and measured the oxygen saturation and vessel diameter. Oxygen saturation was measured in first- and second-degree vessels. A Mann-Whitney U-test was used to compare both groups. Quality of the images was assessed, and a Fisher's exact test was used to compare the proportion of high- and poor-quality images. Results: There was no significant difference in arterial and venous oxygen saturation in patients with glaucoma whether dilated by tropicamide alone or a combination of tropicamide and phenylephrine (97 ± 6% versus 96 ± 5%, p = 0.88 for arterial saturation and 66 ± 6% versus 67 ± 6%, p = 0.78 for venous saturation, n = 27). There was no significant difference in vessel diameter between both conditions for the different vessels (p = 0.61 for arterial saturation and p = 0.51 for venous saturation, n = 27). The proportion of high-quality images was significantly higher after the combination regimen compared with tropicamide only (p = 0.0001). Conclusion: The addition of topical phenylephrine 5% after tropicamide 0.5% improved the proportion of high-quality retinal oximetry images without influencing the retinal oxygen saturation values or the retinal vessel diameter in patients with glaucoma. status: published Article in Journal/Newspaper Iceland KU Leuven: Lirias |
institution |
Open Polar |
collection |
KU Leuven: Lirias |
op_collection_id |
ftunivleuven |
language |
English |
description |
Purpose: To test whether adding topical phenylephrine 5% to tropicamide 0.5% eye drops in the protocol for pupil dilation affects the retinal vessel oximeter measurements in patients with glaucoma. To test whether phenylephrine 5% has an influence as a vasoconstrictor on the retinal vessel width and can improve the proportion of high-quality retinal images in patients with glaucoma. Methods: Retinal images of 66 patients with chronic open-angle glaucoma were obtained before and after the administration of phenylephrine 5% eye drops to patients already dilated with tropicamide 0.5% with the Oxymap Retinal Oximeter (Oxymap ehf, Reykjavik, Iceland). Specialized software, Oxymap Analyzer, analysed the images and measured the oxygen saturation and vessel diameter. Oxygen saturation was measured in first- and second-degree vessels. A Mann-Whitney U-test was used to compare both groups. Quality of the images was assessed, and a Fisher's exact test was used to compare the proportion of high- and poor-quality images. Results: There was no significant difference in arterial and venous oxygen saturation in patients with glaucoma whether dilated by tropicamide alone or a combination of tropicamide and phenylephrine (97 ± 6% versus 96 ± 5%, p = 0.88 for arterial saturation and 66 ± 6% versus 67 ± 6%, p = 0.78 for venous saturation, n = 27). There was no significant difference in vessel diameter between both conditions for the different vessels (p = 0.61 for arterial saturation and p = 0.51 for venous saturation, n = 27). The proportion of high-quality images was significantly higher after the combination regimen compared with tropicamide only (p = 0.0001). Conclusion: The addition of topical phenylephrine 5% after tropicamide 0.5% improved the proportion of high-quality retinal oximetry images without influencing the retinal oxygen saturation values or the retinal vessel diameter in patients with glaucoma. status: published |
format |
Article in Journal/Newspaper |
author |
Vandewalle, Evelien Abegão Pinto, Luis Olafsdottir, Olof Birna Stalmans, Ingeborg |
spellingShingle |
Vandewalle, Evelien Abegão Pinto, Luis Olafsdottir, Olof Birna Stalmans, Ingeborg Phenylephrine 5% added to Tropicamide 0.5% eye drops does not influence retinal oxygen saturation values or retinal vessel diameter in glaucoma patients |
author_facet |
Vandewalle, Evelien Abegão Pinto, Luis Olafsdottir, Olof Birna Stalmans, Ingeborg |
author_sort |
Vandewalle, Evelien |
title |
Phenylephrine 5% added to Tropicamide 0.5% eye drops does not influence retinal oxygen saturation values or retinal vessel diameter in glaucoma patients |
title_short |
Phenylephrine 5% added to Tropicamide 0.5% eye drops does not influence retinal oxygen saturation values or retinal vessel diameter in glaucoma patients |
title_full |
Phenylephrine 5% added to Tropicamide 0.5% eye drops does not influence retinal oxygen saturation values or retinal vessel diameter in glaucoma patients |
title_fullStr |
Phenylephrine 5% added to Tropicamide 0.5% eye drops does not influence retinal oxygen saturation values or retinal vessel diameter in glaucoma patients |
title_full_unstemmed |
Phenylephrine 5% added to Tropicamide 0.5% eye drops does not influence retinal oxygen saturation values or retinal vessel diameter in glaucoma patients |
title_sort |
phenylephrine 5% added to tropicamide 0.5% eye drops does not influence retinal oxygen saturation values or retinal vessel diameter in glaucoma patients |
publisher |
Wiley-Blackwell Publishing, Inc |
publishDate |
2013 |
url |
https://lirias.kuleuven.be/handle/123456789/365799 https://lirias.kuleuven.be/bitstream/123456789/365799/3//Phenylephrine+5%25+added+to+Tropicamide+0.5%25+eye+drops+does+not+influence+retinal+oxygen+saturation+values+or+retinal+vessel+diameter+in+glaucoma+patients.pdf |
genre |
Iceland |
genre_facet |
Iceland |
op_relation |
Acta Ophthalmologica vol:91 issue:8 pages:733-7 https://lirias.kuleuven.be/handle/123456789/365799 1755-375X 1755-3768 https://lirias.kuleuven.be/bitstream/123456789/365799/3//Phenylephrine+5%25+added+to+Tropicamide+0.5%25+eye+drops+does+not+influence+retinal+oxygen+saturation+values+or+retinal+vessel+diameter+in+glaucoma+patients.pdf |
op_rights |
372232;public |
_version_ |
1766042773685796864 |