Single nucleotide polymorphism analysis of corticotropinreleasing factor-binding protein gene in bipolar disorder

• Main Authors: Van den Eede, Filip, Venken, Tine, Van den Bogaert, Ann, Del-Favero, Jurgen, Norrback, Karl-Fredrik, Nilsson, Lars Goran, Adolfsson, Rolf, Van Broeckhoven, Christine, Claes, Stephan
• Format: Article in Journal/Newspaper
• Language: English
• Published: Lippincott williams & wilkins 2007
• Subjects: bipolar disorder; corticotropin-releasing factor-binding protein; genetics; hypothalamic-pituitary-adrenal axis; vulnerability; pituitary-adrenal axis; major depression; hormone test; population; unipolar; cortisol; crf; Northern Sweden
• Online Access: https://lirias.kuleuven.be/handle/123456789/160570

Corticotropin-releasing factor-binding protein regulates the availability of free corticotropin-releasing factor and is a functional candidate gene for affective disorders. The aim of this study was to examine the association between polymorphisms in CRF-BP gene and bipolar disorder in an isolated Swedish population. One hundred and eighty-two patients with bipolar I disorder and 333 controls from Northern Sweden were included in the study. Five single nucleotide polymorphisms and a deletion polymorphism in the CRF-BP gene were genotyped. The haplotype block structure of the gene was considered and the expectation maximization algorithm was adopted to estimate the haplotype frequencies. As a result, there were no significant associations of the different polymorphisms in the CRF-BP gene with bipolar disorder. In conclusion, this study in an isolated Swedish population does not support a role for the CRF-BP gene in the vulnerability for bipolar disorder. status: published