Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism
Venous thromboembolism (VTE) is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of VTE, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and...
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ftunivleiden:oai:scholarlypublications.universiteitleiden.nl:item_3184684 2023-05-15T18:33:53+02:00 Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism Paulsen, B. Skille, H. Smith, E.N. Hveem, K. Gabrielsen, M.E. Braekkan, S.K. Rosendaal, F.R. Frazer, K.A. Gran, O.V. Hansen, J.B. 2020 application/pdf https://hdl.handle.net/1887/3184684 https://haematologica.org/article/view/9948 https://doi.org/10.3324/haematol.2019.224279 en eng https://haematologica.org/article/view/9948 doi:10.3324/haematol.2019.224279 lumc-id: 111847743 https://hdl.handle.net/1887/3184684 https://creativecommons.org/licenses/by-nc/4.0/ CC-BY-NC Haematologica Article / Letter to editor info:eu-repo/semantics/article Text 2020 ftunivleiden https://doi.org/10.3324/haematol.2019.224279 2022-11-30T23:10:12Z Venous thromboembolism (VTE) is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of VTE, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and active cancer on the risk of VTE. Cases with incident VTE (n=640) and a randomly selected age-weighted sub-cohort (n=3,734) were derived from a population-based cohort (the Tromso study). Cox-regression was used to estimate hazard ratios (HR) with 95% confidence intervals (CI) for VTE according to categories of cancer and FGG. In those without cancer, homozygosity at the FGG variant was associated with a 70% (HR 1.7, 95% CI: 1.2-2.3) increased risk of VTE compared to non-carriers. Cancer patients homozygous for the FGG variant had a twofold (HR 2.0, 95% CI: 1.1-3.6) higher risk of VTE than cancer patients without the variant. Moreover, the six-months cumulative incidence of VTE among cancer patients was 6.4% (95% CI: 3.5-11.6) in homozygous carriers of FGG and 3.1% (95% CI: 2.3-4.7) in those without risk alleles. A synergistic effect was observed between rs2066865 and active cancer on the risk of VTE (synergy index: 1.81, 95% CI: 1.02-3.21, attributable proportion: 0.43, 95% CI: 0.11-0.74). In conclusion, homozygosity at the FGG variant and active cancer yielded a synergistic effect on the risk of VTE. Clinical epidemiology Article in Journal/Newspaper Tromso Tromso Leiden University Scholarly Publications Tromso ENVELOPE(16.546,16.546,68.801,68.801) Haematologica 105 7 1963 1968 |
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Open Polar |
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Leiden University Scholarly Publications |
op_collection_id |
ftunivleiden |
language |
English |
description |
Venous thromboembolism (VTE) is a frequent complication in patients with cancer. Homozygous carriers of the fibrinogen gamma gene (FGG) rs2066865 have a moderately increased risk of VTE, but the effect of the FGG variant in cancer is unknown. We aimed to investigate the effect of the FGG variant and active cancer on the risk of VTE. Cases with incident VTE (n=640) and a randomly selected age-weighted sub-cohort (n=3,734) were derived from a population-based cohort (the Tromso study). Cox-regression was used to estimate hazard ratios (HR) with 95% confidence intervals (CI) for VTE according to categories of cancer and FGG. In those without cancer, homozygosity at the FGG variant was associated with a 70% (HR 1.7, 95% CI: 1.2-2.3) increased risk of VTE compared to non-carriers. Cancer patients homozygous for the FGG variant had a twofold (HR 2.0, 95% CI: 1.1-3.6) higher risk of VTE than cancer patients without the variant. Moreover, the six-months cumulative incidence of VTE among cancer patients was 6.4% (95% CI: 3.5-11.6) in homozygous carriers of FGG and 3.1% (95% CI: 2.3-4.7) in those without risk alleles. A synergistic effect was observed between rs2066865 and active cancer on the risk of VTE (synergy index: 1.81, 95% CI: 1.02-3.21, attributable proportion: 0.43, 95% CI: 0.11-0.74). In conclusion, homozygosity at the FGG variant and active cancer yielded a synergistic effect on the risk of VTE. Clinical epidemiology |
format |
Article in Journal/Newspaper |
author |
Paulsen, B. Skille, H. Smith, E.N. Hveem, K. Gabrielsen, M.E. Braekkan, S.K. Rosendaal, F.R. Frazer, K.A. Gran, O.V. Hansen, J.B. |
spellingShingle |
Paulsen, B. Skille, H. Smith, E.N. Hveem, K. Gabrielsen, M.E. Braekkan, S.K. Rosendaal, F.R. Frazer, K.A. Gran, O.V. Hansen, J.B. Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
author_facet |
Paulsen, B. Skille, H. Smith, E.N. Hveem, K. Gabrielsen, M.E. Braekkan, S.K. Rosendaal, F.R. Frazer, K.A. Gran, O.V. Hansen, J.B. |
author_sort |
Paulsen, B. |
title |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_short |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_full |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_fullStr |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_full_unstemmed |
Fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
title_sort |
fibrinogen gamma gene rs2066865 and risk of cancer-related venous thromboembolism |
publishDate |
2020 |
url |
https://hdl.handle.net/1887/3184684 https://haematologica.org/article/view/9948 https://doi.org/10.3324/haematol.2019.224279 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso |
geographic_facet |
Tromso |
genre |
Tromso Tromso |
genre_facet |
Tromso Tromso |
op_source |
Haematologica |
op_relation |
https://haematologica.org/article/view/9948 doi:10.3324/haematol.2019.224279 lumc-id: 111847743 https://hdl.handle.net/1887/3184684 |
op_rights |
https://creativecommons.org/licenses/by-nc/4.0/ |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.3324/haematol.2019.224279 |
container_title |
Haematologica |
container_volume |
105 |
container_issue |
7 |
container_start_page |
1963 |
op_container_end_page |
1968 |
_version_ |
1766218513099259904 |