Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event
Background The role of combined prothrombotic genotypes in cancer-related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5-single nucleotide polymorphism (SNP) score on the risk of VTE in patients with and without cancer using a population-based case-cohort...
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Online Access: | https://hdl.handle.net/1887/3184679 https://onlinelibrary.wiley.com/doi/10.1111/jth.15011 https://doi.org/10.1111/jth.15011 |
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ftunivleiden:oai:scholarlypublications.universiteitleiden.nl:item_3184679 2023-05-15T18:33:54+02:00 Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event Skille, H. Paulsen, B. Hveem, K. Gabrielsen, M.E. Brumpton, B. Hindberg, K. Gran, O.V. Rosendaal, F.R. Braekkan, S.K. Hansen, J.B. 2020 application/pdf https://hdl.handle.net/1887/3184679 https://onlinelibrary.wiley.com/doi/10.1111/jth.15011 https://doi.org/10.1111/jth.15011 en eng https://onlinelibrary.wiley.com/doi/10.1111/jth.15011 doi:10.1111/jth.15011 lumc-id: 111846821 https://hdl.handle.net/1887/3184679 https://creativecommons.org/licenses/by-nc/4.0/ CC-BY-NC Journal of Thrombosis and Haemostasis 5-SNP score cancer deep vein thrombosis prothrombotic genotypes pulmonary embolism risk venous thromboembolism Article / Letter to editor info:eu-repo/semantics/article Text 2020 ftunivleiden https://doi.org/10.1111/jth.15011 2022-11-30T23:10:07Z Background The role of combined prothrombotic genotypes in cancer-related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5-single nucleotide polymorphism (SNP) score on the risk of VTE in patients with and without cancer using a population-based case-cohort. Methods Cases with a first VTE (n = 1493) and a subcohort (n = 13 072) were derived from the Tromso Study (1994-2012) and the Nord-Trondelag Health Study (1995-2008). Five SNPs previously reported as a risk score were genotyped: ABO (rs8176719), F5 (rs6025), F2 (rs1799963), FGG (rs2066865), and F11 (rs2036914). Hazard ratios (HRs) for VTE were estimated according to cancer status and the number of risk alleles in the 5-SNP score (0-1, 2-3, and >= 4 alleles). Results During a median follow-up of 12.3 years, 1496 individuals were diagnosed with cancer, of whom 232 experienced VTE. The VTE risk increased with the number of risk alleles in the 5-SNP score among subjects without and with cancer. In cancer-free subjects, the HR was 2.17 (95% confidence interval [CI] 1.79-2.62) for >= 4 versus 0-1 risk alleles. In cancer patients, the corresponding HR was 1.93 (95% CI 1.28-2.91). The combination of cancer and >= 4 risk alleles yielded a 17-fold (HR 17.1, 95% CI 12.5-23.4) higher risk of VTE compared with cancer-free subjects with 0-1 risk alleles. Conclusion The risk of VTE increases with the number of prothrombotic risk alleles in subjects with and without cancer, and the combination of prothrombotic risk alleles and cancer leads to a highly elevated risk of VTE. Clinical epidemiology Article in Journal/Newspaper Tromso Tromso Leiden University Scholarly Publications Tromso ENVELOPE(16.546,16.546,68.801,68.801) Journal of Thrombosis and Haemostasis 18 11 2861 2869 |
institution |
Open Polar |
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Leiden University Scholarly Publications |
op_collection_id |
ftunivleiden |
language |
English |
topic |
5-SNP score cancer deep vein thrombosis prothrombotic genotypes pulmonary embolism risk venous thromboembolism |
spellingShingle |
5-SNP score cancer deep vein thrombosis prothrombotic genotypes pulmonary embolism risk venous thromboembolism Skille, H. Paulsen, B. Hveem, K. Gabrielsen, M.E. Brumpton, B. Hindberg, K. Gran, O.V. Rosendaal, F.R. Braekkan, S.K. Hansen, J.B. Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event |
topic_facet |
5-SNP score cancer deep vein thrombosis prothrombotic genotypes pulmonary embolism risk venous thromboembolism |
description |
Background The role of combined prothrombotic genotypes in cancer-related venous thromboembolism (VTE) is scarcely studied. We aimed to investigate the impact of a 5-single nucleotide polymorphism (SNP) score on the risk of VTE in patients with and without cancer using a population-based case-cohort. Methods Cases with a first VTE (n = 1493) and a subcohort (n = 13 072) were derived from the Tromso Study (1994-2012) and the Nord-Trondelag Health Study (1995-2008). Five SNPs previously reported as a risk score were genotyped: ABO (rs8176719), F5 (rs6025), F2 (rs1799963), FGG (rs2066865), and F11 (rs2036914). Hazard ratios (HRs) for VTE were estimated according to cancer status and the number of risk alleles in the 5-SNP score (0-1, 2-3, and >= 4 alleles). Results During a median follow-up of 12.3 years, 1496 individuals were diagnosed with cancer, of whom 232 experienced VTE. The VTE risk increased with the number of risk alleles in the 5-SNP score among subjects without and with cancer. In cancer-free subjects, the HR was 2.17 (95% confidence interval [CI] 1.79-2.62) for >= 4 versus 0-1 risk alleles. In cancer patients, the corresponding HR was 1.93 (95% CI 1.28-2.91). The combination of cancer and >= 4 risk alleles yielded a 17-fold (HR 17.1, 95% CI 12.5-23.4) higher risk of VTE compared with cancer-free subjects with 0-1 risk alleles. Conclusion The risk of VTE increases with the number of prothrombotic risk alleles in subjects with and without cancer, and the combination of prothrombotic risk alleles and cancer leads to a highly elevated risk of VTE. Clinical epidemiology |
format |
Article in Journal/Newspaper |
author |
Skille, H. Paulsen, B. Hveem, K. Gabrielsen, M.E. Brumpton, B. Hindberg, K. Gran, O.V. Rosendaal, F.R. Braekkan, S.K. Hansen, J.B. |
author_facet |
Skille, H. Paulsen, B. Hveem, K. Gabrielsen, M.E. Brumpton, B. Hindberg, K. Gran, O.V. Rosendaal, F.R. Braekkan, S.K. Hansen, J.B. |
author_sort |
Skille, H. |
title |
Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event |
title_short |
Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event |
title_full |
Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event |
title_fullStr |
Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event |
title_full_unstemmed |
Combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event |
title_sort |
combined effects of five prothrombotic genotypes and cancer on the risk of a first venous thromboembolic event |
publishDate |
2020 |
url |
https://hdl.handle.net/1887/3184679 https://onlinelibrary.wiley.com/doi/10.1111/jth.15011 https://doi.org/10.1111/jth.15011 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso |
geographic_facet |
Tromso |
genre |
Tromso Tromso |
genre_facet |
Tromso Tromso |
op_source |
Journal of Thrombosis and Haemostasis |
op_relation |
https://onlinelibrary.wiley.com/doi/10.1111/jth.15011 doi:10.1111/jth.15011 lumc-id: 111846821 https://hdl.handle.net/1887/3184679 |
op_rights |
https://creativecommons.org/licenses/by-nc/4.0/ |
op_rightsnorm |
CC-BY-NC |
op_doi |
https://doi.org/10.1111/jth.15011 |
container_title |
Journal of Thrombosis and Haemostasis |
container_volume |
18 |
container_issue |
11 |
container_start_page |
2861 |
op_container_end_page |
2869 |
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1766218527971213312 |