Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism
Background Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE). Objectives To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case-cohort recruited from a general population. Methods Cases with a...
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Online Access: | https://hdl.handle.net/1887/122523 https://doi.org/10.1111/jth.14493 |
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ftunivleiden:oai:scholarlypublications.universiteitleiden.nl:item_2987764 2023-05-15T18:33:54+02:00 Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism Smabrekke, B. Rinde, L.B. Evensen, L.H. Morelli, V.M. Hveem, K. Gabrielsen, M.E. Njolstad, I. Mathiesen, E.B. Rosendaal, F.R. Braekkan, S.K. Hansen, J.B. 2019 https://hdl.handle.net/1887/122523 https://doi.org/10.1111/jth.14493 en eng doi:10.1111/jth.14493 lumc-id: 81604858 https://hdl.handle.net/1887/122523 Journal of Thrombosis and Haemostasis genotype myocardial infarction prospective studies risk factors venous thromboembolism Article / Letter to editor info:eu-repo/semantics/article Text 2019 ftunivleiden https://doi.org/10.1111/jth.14493 2021-11-03T23:21:19Z Background Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE). Objectives To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case-cohort recruited from a general population. Methods Cases with a first VTE (n = 1493) and a subcohort (n = 13 072) were sampled from the Tromso study (1994-2012) and the Nord-Trondelag health (HUNT) study (1995-2008). The DNA samples were genotyped for rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2066865 (FGG), and rs2036914 (F11). Participants with missing information on risk alleles (n = 175), FHMI (n = 2769), and BMI (n = 52) were excluded. Cox regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CI) for VTE. To explore the role of prothrombotic genotypes for the association between FHMI and VTE, we (a) included the genotypes in the multivariable-adjusted models and (b) assessed the joint effects between FHMI and genotypes on VTE risk. Results The FHMI was associated with a 1.3-fold increased risk of VTE (HR 1.32, 95% CI 1.16-1.50) and 1.5-fold increased risk of unprovoked VTE (HR 1.47, 95% CI 1.22-1.78). The risk of VTE by FHMI did not alter after adjustment for the five genotypes. The combination of FHMI and the different prothrombotic genotypes did not result in an excess VTE risk (i.e. no biological interaction). Conclusions Our findings suggest that the risk of VTE by FHMI is not explained by rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2066865 (FGG), and rs2036914 (F11). The combination of FHMI with prothrombotic genotypes had an additive effect on VTE risk. Clinical epidemiology Article in Journal/Newspaper Tromso Tromso Leiden University Scholarly Publications Tromso ENVELOPE(16.546,16.546,68.801,68.801) Journal of Thrombosis and Haemostasis 17 8 1363 1371 |
institution |
Open Polar |
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Leiden University Scholarly Publications |
op_collection_id |
ftunivleiden |
language |
English |
topic |
genotype myocardial infarction prospective studies risk factors venous thromboembolism |
spellingShingle |
genotype myocardial infarction prospective studies risk factors venous thromboembolism Smabrekke, B. Rinde, L.B. Evensen, L.H. Morelli, V.M. Hveem, K. Gabrielsen, M.E. Njolstad, I. Mathiesen, E.B. Rosendaal, F.R. Braekkan, S.K. Hansen, J.B. Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
topic_facet |
genotype myocardial infarction prospective studies risk factors venous thromboembolism |
description |
Background Family history of myocardial infarction (FHMI) is known to increase the risk of venous thromboembolism (VTE). Objectives To investigate the effect of prothrombotic genotypes on the association between FHMI and VTE in a case-cohort recruited from a general population. Methods Cases with a first VTE (n = 1493) and a subcohort (n = 13 072) were sampled from the Tromso study (1994-2012) and the Nord-Trondelag health (HUNT) study (1995-2008). The DNA samples were genotyped for rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2066865 (FGG), and rs2036914 (F11). Participants with missing information on risk alleles (n = 175), FHMI (n = 2769), and BMI (n = 52) were excluded. Cox regression models were used to estimate hazard ratios (HRs) with 95% confidence intervals (CI) for VTE. To explore the role of prothrombotic genotypes for the association between FHMI and VTE, we (a) included the genotypes in the multivariable-adjusted models and (b) assessed the joint effects between FHMI and genotypes on VTE risk. Results The FHMI was associated with a 1.3-fold increased risk of VTE (HR 1.32, 95% CI 1.16-1.50) and 1.5-fold increased risk of unprovoked VTE (HR 1.47, 95% CI 1.22-1.78). The risk of VTE by FHMI did not alter after adjustment for the five genotypes. The combination of FHMI and the different prothrombotic genotypes did not result in an excess VTE risk (i.e. no biological interaction). Conclusions Our findings suggest that the risk of VTE by FHMI is not explained by rs8176719 (ABO), rs6025 (F5), rs1799963 (F2), rs2066865 (FGG), and rs2036914 (F11). The combination of FHMI with prothrombotic genotypes had an additive effect on VTE risk. Clinical epidemiology |
format |
Article in Journal/Newspaper |
author |
Smabrekke, B. Rinde, L.B. Evensen, L.H. Morelli, V.M. Hveem, K. Gabrielsen, M.E. Njolstad, I. Mathiesen, E.B. Rosendaal, F.R. Braekkan, S.K. Hansen, J.B. |
author_facet |
Smabrekke, B. Rinde, L.B. Evensen, L.H. Morelli, V.M. Hveem, K. Gabrielsen, M.E. Njolstad, I. Mathiesen, E.B. Rosendaal, F.R. Braekkan, S.K. Hansen, J.B. |
author_sort |
Smabrekke, B. |
title |
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
title_short |
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
title_full |
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
title_fullStr |
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
title_full_unstemmed |
Impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
title_sort |
impact of prothrombotic genotypes on the association between family history of myocardial infarction and venous thromboembolism |
publishDate |
2019 |
url |
https://hdl.handle.net/1887/122523 https://doi.org/10.1111/jth.14493 |
long_lat |
ENVELOPE(16.546,16.546,68.801,68.801) |
geographic |
Tromso |
geographic_facet |
Tromso |
genre |
Tromso Tromso |
genre_facet |
Tromso Tromso |
op_source |
Journal of Thrombosis and Haemostasis |
op_relation |
doi:10.1111/jth.14493 lumc-id: 81604858 https://hdl.handle.net/1887/122523 |
op_doi |
https://doi.org/10.1111/jth.14493 |
container_title |
Journal of Thrombosis and Haemostasis |
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17 |
container_issue |
8 |
container_start_page |
1363 |
op_container_end_page |
1371 |
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