Adult survival in migratory caribou is negatively associated with MHC functional diversity

Genes of the major histocompatibility complex (MHC) are involved in acquired immunity in vertebrates. Only a few studies have investigated the fitness consequences of MHC gene diversity in wild populations. Here, we looked at the association between annual survival and body mass and MHC–DRB exon 2 (...

Full description

Bibliographic Details
Published in:Heredity
Main Authors: Gagnon, Marianne, Yannic, Glenn, Boyer, Frédéric, Côté, Steeve D.
Format: Other/Unknown Material
Language:English
Published: Nature 2021
Subjects:
Online Access:https://hdl.handle.net/20.500.11794/69541
https://doi.org/10.1038/s41437-020-0347-3
id ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/69541
record_format openpolar
spelling ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/69541 2024-06-23T07:56:22+00:00 Adult survival in migratory caribou is negatively associated with MHC functional diversity Gagnon, Marianne Yannic, Glenn Boyer, Frédéric Côté, Steeve D. 2021-07-07T14:30:08Z application/pdf https://hdl.handle.net/20.500.11794/69541 https://doi.org/10.1038/s41437-020-0347-3 eng eng Nature 0018-067X http://hdl.handle.net/20.500.11794/69541 doi:10.1038/s41437-020-0347-3 32728043 http://purl.org/coar/access_right/c_16ec Gènes Ir Caribou des bois -- Mortalité Caribou des bois -- Poids Variabilité génétique article de recherche COAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche 2021 ftunivlavalcorp https://doi.org/20.500.11794/6954110.1038/s41437-020-0347-3 2024-06-10T23:42:53Z Genes of the major histocompatibility complex (MHC) are involved in acquired immunity in vertebrates. Only a few studies have investigated the fitness consequences of MHC gene diversity in wild populations. Here, we looked at the association between annual survival and body mass and MHC–DRB exon 2 (MHC–DRB) genetic diversity, obtained from high-throughput sequencing, in two declining migratory caribou (Rangifer tarandus) herds. To disentangle the potential direct and general effects of MHC–DRB genetic diversity, we compared different indices of diversity that were either based on DNA-sequence variation or on physicochemical divergence of the translated peptides, thereby covering a gradient of allelic-to-functional diversity. We found that (1) body mass was not related to MHC–DRB diversity or genotype, and (2) adult survival probability was negatively associated with point accepted mutation distance, a corrected distance that considers the likelihood of each amino acid substitution to be accepted by natural selection. In addition, we found no evidence of fluctuating selection over time on MHC–DRB diversity. We concluded that direct effects were involved in the negative relationship between MHC functional diversity and survival, although the mechanism underlying this result remains unclear. A possible explanation could be that individuals with higher MHC diversity suffer higher costs of immunity (immunopathology). Our results suggest that genetic diversity is not always beneficial even in genes that are likely to be strongly shaped by balancing selection. Other/Unknown Material Rangifer tarandus Université Laval: CorpusUL Heredity 125 5 290 303
institution Open Polar
collection Université Laval: CorpusUL
op_collection_id ftunivlavalcorp
language English
topic Gènes Ir
Caribou des bois -- Mortalité
Caribou des bois -- Poids
Variabilité génétique
spellingShingle Gènes Ir
Caribou des bois -- Mortalité
Caribou des bois -- Poids
Variabilité génétique
Gagnon, Marianne
Yannic, Glenn
Boyer, Frédéric
Côté, Steeve D.
Adult survival in migratory caribou is negatively associated with MHC functional diversity
topic_facet Gènes Ir
Caribou des bois -- Mortalité
Caribou des bois -- Poids
Variabilité génétique
description Genes of the major histocompatibility complex (MHC) are involved in acquired immunity in vertebrates. Only a few studies have investigated the fitness consequences of MHC gene diversity in wild populations. Here, we looked at the association between annual survival and body mass and MHC–DRB exon 2 (MHC–DRB) genetic diversity, obtained from high-throughput sequencing, in two declining migratory caribou (Rangifer tarandus) herds. To disentangle the potential direct and general effects of MHC–DRB genetic diversity, we compared different indices of diversity that were either based on DNA-sequence variation or on physicochemical divergence of the translated peptides, thereby covering a gradient of allelic-to-functional diversity. We found that (1) body mass was not related to MHC–DRB diversity or genotype, and (2) adult survival probability was negatively associated with point accepted mutation distance, a corrected distance that considers the likelihood of each amino acid substitution to be accepted by natural selection. In addition, we found no evidence of fluctuating selection over time on MHC–DRB diversity. We concluded that direct effects were involved in the negative relationship between MHC functional diversity and survival, although the mechanism underlying this result remains unclear. A possible explanation could be that individuals with higher MHC diversity suffer higher costs of immunity (immunopathology). Our results suggest that genetic diversity is not always beneficial even in genes that are likely to be strongly shaped by balancing selection.
format Other/Unknown Material
author Gagnon, Marianne
Yannic, Glenn
Boyer, Frédéric
Côté, Steeve D.
author_facet Gagnon, Marianne
Yannic, Glenn
Boyer, Frédéric
Côté, Steeve D.
author_sort Gagnon, Marianne
title Adult survival in migratory caribou is negatively associated with MHC functional diversity
title_short Adult survival in migratory caribou is negatively associated with MHC functional diversity
title_full Adult survival in migratory caribou is negatively associated with MHC functional diversity
title_fullStr Adult survival in migratory caribou is negatively associated with MHC functional diversity
title_full_unstemmed Adult survival in migratory caribou is negatively associated with MHC functional diversity
title_sort adult survival in migratory caribou is negatively associated with mhc functional diversity
publisher Nature
publishDate 2021
url https://hdl.handle.net/20.500.11794/69541
https://doi.org/10.1038/s41437-020-0347-3
genre Rangifer tarandus
genre_facet Rangifer tarandus
op_relation 0018-067X
http://hdl.handle.net/20.500.11794/69541
doi:10.1038/s41437-020-0347-3
32728043
op_rights http://purl.org/coar/access_right/c_16ec
op_doi https://doi.org/20.500.11794/6954110.1038/s41437-020-0347-3
container_title Heredity
container_volume 125
container_issue 5
container_start_page 290
op_container_end_page 303
_version_ 1802649411379003392