Adult survival in migratory caribou is negatively associated with MHC functional diversity
Genes of the major histocompatibility complex (MHC) are involved in acquired immunity in vertebrates. Only a few studies have investigated the fitness consequences of MHC gene diversity in wild populations. Here, we looked at the association between annual survival and body mass and MHC–DRB exon 2 (...
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ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/69541 2024-06-23T07:56:22+00:00 Adult survival in migratory caribou is negatively associated with MHC functional diversity Gagnon, Marianne Yannic, Glenn Boyer, Frédéric Côté, Steeve D. 2021-07-07T14:30:08Z application/pdf https://hdl.handle.net/20.500.11794/69541 https://doi.org/10.1038/s41437-020-0347-3 eng eng Nature 0018-067X http://hdl.handle.net/20.500.11794/69541 doi:10.1038/s41437-020-0347-3 32728043 http://purl.org/coar/access_right/c_16ec Gènes Ir Caribou des bois -- Mortalité Caribou des bois -- Poids Variabilité génétique article de recherche COAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche 2021 ftunivlavalcorp https://doi.org/20.500.11794/6954110.1038/s41437-020-0347-3 2024-06-10T23:42:53Z Genes of the major histocompatibility complex (MHC) are involved in acquired immunity in vertebrates. Only a few studies have investigated the fitness consequences of MHC gene diversity in wild populations. Here, we looked at the association between annual survival and body mass and MHC–DRB exon 2 (MHC–DRB) genetic diversity, obtained from high-throughput sequencing, in two declining migratory caribou (Rangifer tarandus) herds. To disentangle the potential direct and general effects of MHC–DRB genetic diversity, we compared different indices of diversity that were either based on DNA-sequence variation or on physicochemical divergence of the translated peptides, thereby covering a gradient of allelic-to-functional diversity. We found that (1) body mass was not related to MHC–DRB diversity or genotype, and (2) adult survival probability was negatively associated with point accepted mutation distance, a corrected distance that considers the likelihood of each amino acid substitution to be accepted by natural selection. In addition, we found no evidence of fluctuating selection over time on MHC–DRB diversity. We concluded that direct effects were involved in the negative relationship between MHC functional diversity and survival, although the mechanism underlying this result remains unclear. A possible explanation could be that individuals with higher MHC diversity suffer higher costs of immunity (immunopathology). Our results suggest that genetic diversity is not always beneficial even in genes that are likely to be strongly shaped by balancing selection. Other/Unknown Material Rangifer tarandus Université Laval: CorpusUL Heredity 125 5 290 303 |
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Open Polar |
collection |
Université Laval: CorpusUL |
op_collection_id |
ftunivlavalcorp |
language |
English |
topic |
Gènes Ir Caribou des bois -- Mortalité Caribou des bois -- Poids Variabilité génétique |
spellingShingle |
Gènes Ir Caribou des bois -- Mortalité Caribou des bois -- Poids Variabilité génétique Gagnon, Marianne Yannic, Glenn Boyer, Frédéric Côté, Steeve D. Adult survival in migratory caribou is negatively associated with MHC functional diversity |
topic_facet |
Gènes Ir Caribou des bois -- Mortalité Caribou des bois -- Poids Variabilité génétique |
description |
Genes of the major histocompatibility complex (MHC) are involved in acquired immunity in vertebrates. Only a few studies have investigated the fitness consequences of MHC gene diversity in wild populations. Here, we looked at the association between annual survival and body mass and MHC–DRB exon 2 (MHC–DRB) genetic diversity, obtained from high-throughput sequencing, in two declining migratory caribou (Rangifer tarandus) herds. To disentangle the potential direct and general effects of MHC–DRB genetic diversity, we compared different indices of diversity that were either based on DNA-sequence variation or on physicochemical divergence of the translated peptides, thereby covering a gradient of allelic-to-functional diversity. We found that (1) body mass was not related to MHC–DRB diversity or genotype, and (2) adult survival probability was negatively associated with point accepted mutation distance, a corrected distance that considers the likelihood of each amino acid substitution to be accepted by natural selection. In addition, we found no evidence of fluctuating selection over time on MHC–DRB diversity. We concluded that direct effects were involved in the negative relationship between MHC functional diversity and survival, although the mechanism underlying this result remains unclear. A possible explanation could be that individuals with higher MHC diversity suffer higher costs of immunity (immunopathology). Our results suggest that genetic diversity is not always beneficial even in genes that are likely to be strongly shaped by balancing selection. |
format |
Other/Unknown Material |
author |
Gagnon, Marianne Yannic, Glenn Boyer, Frédéric Côté, Steeve D. |
author_facet |
Gagnon, Marianne Yannic, Glenn Boyer, Frédéric Côté, Steeve D. |
author_sort |
Gagnon, Marianne |
title |
Adult survival in migratory caribou is negatively associated with MHC functional diversity |
title_short |
Adult survival in migratory caribou is negatively associated with MHC functional diversity |
title_full |
Adult survival in migratory caribou is negatively associated with MHC functional diversity |
title_fullStr |
Adult survival in migratory caribou is negatively associated with MHC functional diversity |
title_full_unstemmed |
Adult survival in migratory caribou is negatively associated with MHC functional diversity |
title_sort |
adult survival in migratory caribou is negatively associated with mhc functional diversity |
publisher |
Nature |
publishDate |
2021 |
url |
https://hdl.handle.net/20.500.11794/69541 https://doi.org/10.1038/s41437-020-0347-3 |
genre |
Rangifer tarandus |
genre_facet |
Rangifer tarandus |
op_relation |
0018-067X http://hdl.handle.net/20.500.11794/69541 doi:10.1038/s41437-020-0347-3 32728043 |
op_rights |
http://purl.org/coar/access_right/c_16ec |
op_doi |
https://doi.org/20.500.11794/6954110.1038/s41437-020-0347-3 |
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Heredity |
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125 |
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5 |
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290 |
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303 |
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1802649411379003392 |