Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population
Background : Tissue concentrations of fatty acids (FAs) and genetic variations are well-known factors which affect the cardiovascular disease (CVD) risk. The objective was to examine whether the genetic variability of 20 candidate genes and red blood cells (RBCs) percentage of total n-3 polyunsatura...
Published in: | Nutrition & Metabolism |
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Language: | English |
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BioMed Central Ltd.
2020
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Online Access: | https://hdl.handle.net/20.500.11794/40204 https://doi.org/10.1186/1743-7075-10-26 |
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ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/40204 2024-06-23T07:54:11+00:00 Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population Abdous, Belkacem Proust, Françoise Rudkowska, Iwona Hegele, Robert A. Ouellette, Catherine Boiteau, Véronique Julien, Pierre Dewailly, Éric Vohl, Marie-Claude Dubé-Linteau, Ariane Giguère, Yves Chateau-Degat, Marie-Ludivine 2020-08-27T14:11:21Z application/pdf https://hdl.handle.net/20.500.11794/40204 https://doi.org/10.1186/1743-7075-10-26 eng eng BioMed Central Ltd. 1743-7075 http://hdl.handle.net/20.500.11794/40204 doi:10.1186/1743-7075-10-26 3639855 http://purl.org/coar/access_right/c_abf2 Nutrigenetics n-3 PUFAs Plasma lipids Gene-nutrient interactions Nutrigénomique Acides gras oméga 3 Lipides plasmatiques Cœur -- Maladies -- Facteurs de risque Inuits -- Santé et hygiène Polymorphisme génétique article de recherche COAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche 2020 ftunivlavalcorp https://doi.org/20.500.11794/4020410.1186/1743-7075-10-26 2024-06-03T23:43:59Z Background : Tissue concentrations of fatty acids (FAs) and genetic variations are well-known factors which affect the cardiovascular disease (CVD) risk. The objective was to examine whether the genetic variability of 20 candidate genes and red blood cells (RBCs) percentage of total n-3 polyunsaturated fatty acids (PUFA), a biomarker of dietary n-3 PUFA intake, modulate lipid related CVD risk factors in the Inuit population. Methods : Data from the Qanuippitaa Nunavik Health Survey (n = 553) were analysed via multivariate regression models with 40 known polymorphisms, RBCs percentage of n-3 PUFA, and the interaction term to take into account the effect on plasma lipid and apolipoporotein levels. Results : Individuals being heterozygotes for CETP C-4502T (rs183130) or G-971A (rs4783961) together with higher n-3 PUFA had lower triacylglycerol (TG) concentrations compared to homozygotes for the minor allele. Further, effects of a stronger beneficial association between n-3 PUFA in RBCs and plasma lipid parameters- including lower total cholesterol (TC), lower low-density lipoprotein cholesterol (LDL-C) or higher high-density lipoprotein cholesterol (HDL-C) concentrations- were associated with AGT M235T (rs699) TT genotype, CETP G-971A (rs4783961) AG genotype, T allele carriers of CETP C-4502T (rs183130), and T allele carriers of CETP Ile405Val (rs5882). In contrast, higher n-3 PUFA in RBCs were associated with adverse lipid profiles- including increased LDL-C, increased apolipoprotein B100 or decreased HDL-C concentrations- in G allele carriers of the APOA5 -3 A/G (rs651821), C allele carriers of APOA5 T-1131C (rs662799), G carriers of APOC3 SstI (rs5128) and G carriers of APOA4 Asn147Ser (rs5104). Conclusion : Overall, these results suggest that percentage of total n-3 PUFA of RBCs are associated with lipids related CVD risk factors conferred by genetic variations in the Inuit population. Other/Unknown Material inuit inuits Nunavik Université Laval: CorpusUL Nunavik Nutrition & Metabolism 10 1 26 |
institution |
Open Polar |
collection |
Université Laval: CorpusUL |
op_collection_id |
ftunivlavalcorp |
language |
English |
topic |
Nutrigenetics n-3 PUFAs Plasma lipids Gene-nutrient interactions Nutrigénomique Acides gras oméga 3 Lipides plasmatiques Cœur -- Maladies -- Facteurs de risque Inuits -- Santé et hygiène Polymorphisme génétique |
spellingShingle |
Nutrigenetics n-3 PUFAs Plasma lipids Gene-nutrient interactions Nutrigénomique Acides gras oméga 3 Lipides plasmatiques Cœur -- Maladies -- Facteurs de risque Inuits -- Santé et hygiène Polymorphisme génétique Abdous, Belkacem Proust, Françoise Rudkowska, Iwona Hegele, Robert A. Ouellette, Catherine Boiteau, Véronique Julien, Pierre Dewailly, Éric Vohl, Marie-Claude Dubé-Linteau, Ariane Giguère, Yves Chateau-Degat, Marie-Ludivine Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
topic_facet |
Nutrigenetics n-3 PUFAs Plasma lipids Gene-nutrient interactions Nutrigénomique Acides gras oméga 3 Lipides plasmatiques Cœur -- Maladies -- Facteurs de risque Inuits -- Santé et hygiène Polymorphisme génétique |
description |
Background : Tissue concentrations of fatty acids (FAs) and genetic variations are well-known factors which affect the cardiovascular disease (CVD) risk. The objective was to examine whether the genetic variability of 20 candidate genes and red blood cells (RBCs) percentage of total n-3 polyunsaturated fatty acids (PUFA), a biomarker of dietary n-3 PUFA intake, modulate lipid related CVD risk factors in the Inuit population. Methods : Data from the Qanuippitaa Nunavik Health Survey (n = 553) were analysed via multivariate regression models with 40 known polymorphisms, RBCs percentage of n-3 PUFA, and the interaction term to take into account the effect on plasma lipid and apolipoporotein levels. Results : Individuals being heterozygotes for CETP C-4502T (rs183130) or G-971A (rs4783961) together with higher n-3 PUFA had lower triacylglycerol (TG) concentrations compared to homozygotes for the minor allele. Further, effects of a stronger beneficial association between n-3 PUFA in RBCs and plasma lipid parameters- including lower total cholesterol (TC), lower low-density lipoprotein cholesterol (LDL-C) or higher high-density lipoprotein cholesterol (HDL-C) concentrations- were associated with AGT M235T (rs699) TT genotype, CETP G-971A (rs4783961) AG genotype, T allele carriers of CETP C-4502T (rs183130), and T allele carriers of CETP Ile405Val (rs5882). In contrast, higher n-3 PUFA in RBCs were associated with adverse lipid profiles- including increased LDL-C, increased apolipoprotein B100 or decreased HDL-C concentrations- in G allele carriers of the APOA5 -3 A/G (rs651821), C allele carriers of APOA5 T-1131C (rs662799), G carriers of APOC3 SstI (rs5128) and G carriers of APOA4 Asn147Ser (rs5104). Conclusion : Overall, these results suggest that percentage of total n-3 PUFA of RBCs are associated with lipids related CVD risk factors conferred by genetic variations in the Inuit population. |
format |
Other/Unknown Material |
author |
Abdous, Belkacem Proust, Françoise Rudkowska, Iwona Hegele, Robert A. Ouellette, Catherine Boiteau, Véronique Julien, Pierre Dewailly, Éric Vohl, Marie-Claude Dubé-Linteau, Ariane Giguère, Yves Chateau-Degat, Marie-Ludivine |
author_facet |
Abdous, Belkacem Proust, Françoise Rudkowska, Iwona Hegele, Robert A. Ouellette, Catherine Boiteau, Véronique Julien, Pierre Dewailly, Éric Vohl, Marie-Claude Dubé-Linteau, Ariane Giguère, Yves Chateau-Degat, Marie-Ludivine |
author_sort |
Abdous, Belkacem |
title |
Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
title_short |
Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
title_full |
Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
title_fullStr |
Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
title_full_unstemmed |
Omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the Inuit population |
title_sort |
omega-3 fatty acids, polymorphisms and lipid related cardiovascular disease risk factors in the inuit population |
publisher |
BioMed Central Ltd. |
publishDate |
2020 |
url |
https://hdl.handle.net/20.500.11794/40204 https://doi.org/10.1186/1743-7075-10-26 |
geographic |
Nunavik |
geographic_facet |
Nunavik |
genre |
inuit inuits Nunavik |
genre_facet |
inuit inuits Nunavik |
op_relation |
1743-7075 http://hdl.handle.net/20.500.11794/40204 doi:10.1186/1743-7075-10-26 3639855 |
op_rights |
http://purl.org/coar/access_right/c_abf2 |
op_doi |
https://doi.org/20.500.11794/4020410.1186/1743-7075-10-26 |
container_title |
Nutrition & Metabolism |
container_volume |
10 |
container_issue |
1 |
container_start_page |
26 |
_version_ |
1802646238173069312 |