Selenoneine is a major selenium species in beluga skin and red blood cells of Inuit from Nunavik
Nunavimmiut (Inuit of Nunavik, Northern Quebec, Canada) exhibit a high selenium (Se) status because oftheir frequent consumption of marine mammal foods. Indirect evidence from our previous studies hadsuggested that selenoneineea novel selenocompoundemay be accumulating in the blood of Nuna-vimmiut....
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Elsevier Ltd
2020
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Online Access: | https://hdl.handle.net/20.500.11794/38377 https://doi.org/10.1016/j.chemosphere.2019.04.191 |
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ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/38377 2024-06-23T07:51:41+00:00 Selenoneine is a major selenium species in beluga skin and red blood cells of Inuit from Nunavik Lemire, Mélanie Dumas, Pierre Little, Matthew Achouba, Adel Ayotte, Pierre Ouellet, Nathalie Nunavik (Québec) 2020-03-26T14:23:11Z application/pdf https://hdl.handle.net/20.500.11794/38377 https://doi.org/10.1016/j.chemosphere.2019.04.191 eng eng Elsevier Ltd 0045-6535 http://hdl.handle.net/20.500.11794/38377 doi:10.1016/j.chemosphere.2019.04.191 31100626 http://purl.org/coar/access_right/c_abf2 Selenium Selenoneine Inuit Beluga whale Methylmercury Nunavik Sélénium -- Composés Inuits -- Alimentation Inuits -- Santé et hygiène Béluga Érythrocytes Méthylmercure article de recherche COAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche 2020 ftunivlavalcorp https://doi.org/20.500.11794/3837710.1016/j.chemosphere.2019.04.191 2024-06-03T23:43:59Z Nunavimmiut (Inuit of Nunavik, Northern Quebec, Canada) exhibit a high selenium (Se) status because oftheir frequent consumption of marine mammal foods. Indirect evidence from our previous studies hadsuggested that selenoneineea novel selenocompoundemay be accumulating in the blood of Nuna-vimmiut. We used a liquid-chromatography/inductively coupled tandem mass spectrometry (LC-ICP-MS/MS) method to measure concentrations of selenoneine and its methylated metabolite Se-methylselenoneine in archived red blood cells (RBC) obtained from 210 Nunavimmiut living in com-munities along the Hudson Strait, where marine mammal hunting and consumption are most frequent inNunavik. This method was adapted to quantify selenoneine and its methylated metabolite in belugamattaaq, an Inuit delicacy consisting of the skin with the underlying layer of fat and the major dietarysource of Se for Nunavimmiut. Total selenium concentration was also measured in RBC and belugamattaaq samples by isotope dilution ICP-MS/MS. The median selenoneine concentration in RBC was413mg Se/L (range¼3.20e3230mg Se/L), representing 54% (median) of total Se content (range¼1.6e91%). Quantification of selenoneine infive beluga mattaaq samples (skin layer) from Nunavik revealed amedian concentration of 1.8mg Se/g wet wt (range¼1.2e7.4mg Se/g), constituting 54% (median) of thetotal Se content (range¼44e74%). Se-methylselenoneine was also detected in Inuit RBC but not inbeluga mattaaq, suggesting that selenoneine undergoes methylation in humans. Selenoneine may protect Nunavimmiut from methylmecury toxicity by increasing its demethylation in RBC and in turndecreasing its distribution to target organs. Other/Unknown Material Beluga Beluga whale Beluga* Béluga* Hudson Strait inuit inuits Nunavik Université Laval: CorpusUL Canada Hudson Hudson Strait ENVELOPE(-70.000,-70.000,62.000,62.000) Nunavik Chemosphere 229 549 558 |
institution |
Open Polar |
collection |
Université Laval: CorpusUL |
op_collection_id |
ftunivlavalcorp |
language |
English |
topic |
Selenium Selenoneine Inuit Beluga whale Methylmercury Nunavik Sélénium -- Composés Inuits -- Alimentation Inuits -- Santé et hygiène Béluga Érythrocytes Méthylmercure |
spellingShingle |
Selenium Selenoneine Inuit Beluga whale Methylmercury Nunavik Sélénium -- Composés Inuits -- Alimentation Inuits -- Santé et hygiène Béluga Érythrocytes Méthylmercure Lemire, Mélanie Dumas, Pierre Little, Matthew Achouba, Adel Ayotte, Pierre Ouellet, Nathalie Selenoneine is a major selenium species in beluga skin and red blood cells of Inuit from Nunavik |
topic_facet |
Selenium Selenoneine Inuit Beluga whale Methylmercury Nunavik Sélénium -- Composés Inuits -- Alimentation Inuits -- Santé et hygiène Béluga Érythrocytes Méthylmercure |
description |
Nunavimmiut (Inuit of Nunavik, Northern Quebec, Canada) exhibit a high selenium (Se) status because oftheir frequent consumption of marine mammal foods. Indirect evidence from our previous studies hadsuggested that selenoneineea novel selenocompoundemay be accumulating in the blood of Nuna-vimmiut. We used a liquid-chromatography/inductively coupled tandem mass spectrometry (LC-ICP-MS/MS) method to measure concentrations of selenoneine and its methylated metabolite Se-methylselenoneine in archived red blood cells (RBC) obtained from 210 Nunavimmiut living in com-munities along the Hudson Strait, where marine mammal hunting and consumption are most frequent inNunavik. This method was adapted to quantify selenoneine and its methylated metabolite in belugamattaaq, an Inuit delicacy consisting of the skin with the underlying layer of fat and the major dietarysource of Se for Nunavimmiut. Total selenium concentration was also measured in RBC and belugamattaaq samples by isotope dilution ICP-MS/MS. The median selenoneine concentration in RBC was413mg Se/L (range¼3.20e3230mg Se/L), representing 54% (median) of total Se content (range¼1.6e91%). Quantification of selenoneine infive beluga mattaaq samples (skin layer) from Nunavik revealed amedian concentration of 1.8mg Se/g wet wt (range¼1.2e7.4mg Se/g), constituting 54% (median) of thetotal Se content (range¼44e74%). Se-methylselenoneine was also detected in Inuit RBC but not inbeluga mattaaq, suggesting that selenoneine undergoes methylation in humans. Selenoneine may protect Nunavimmiut from methylmecury toxicity by increasing its demethylation in RBC and in turndecreasing its distribution to target organs. |
format |
Other/Unknown Material |
author |
Lemire, Mélanie Dumas, Pierre Little, Matthew Achouba, Adel Ayotte, Pierre Ouellet, Nathalie |
author_facet |
Lemire, Mélanie Dumas, Pierre Little, Matthew Achouba, Adel Ayotte, Pierre Ouellet, Nathalie |
author_sort |
Lemire, Mélanie |
title |
Selenoneine is a major selenium species in beluga skin and red blood cells of Inuit from Nunavik |
title_short |
Selenoneine is a major selenium species in beluga skin and red blood cells of Inuit from Nunavik |
title_full |
Selenoneine is a major selenium species in beluga skin and red blood cells of Inuit from Nunavik |
title_fullStr |
Selenoneine is a major selenium species in beluga skin and red blood cells of Inuit from Nunavik |
title_full_unstemmed |
Selenoneine is a major selenium species in beluga skin and red blood cells of Inuit from Nunavik |
title_sort |
selenoneine is a major selenium species in beluga skin and red blood cells of inuit from nunavik |
publisher |
Elsevier Ltd |
publishDate |
2020 |
url |
https://hdl.handle.net/20.500.11794/38377 https://doi.org/10.1016/j.chemosphere.2019.04.191 |
op_coverage |
Nunavik (Québec) |
long_lat |
ENVELOPE(-70.000,-70.000,62.000,62.000) |
geographic |
Canada Hudson Hudson Strait Nunavik |
geographic_facet |
Canada Hudson Hudson Strait Nunavik |
genre |
Beluga Beluga whale Beluga* Béluga* Hudson Strait inuit inuits Nunavik |
genre_facet |
Beluga Beluga whale Beluga* Béluga* Hudson Strait inuit inuits Nunavik |
op_relation |
0045-6535 http://hdl.handle.net/20.500.11794/38377 doi:10.1016/j.chemosphere.2019.04.191 31100626 |
op_rights |
http://purl.org/coar/access_right/c_abf2 |
op_doi |
https://doi.org/20.500.11794/3837710.1016/j.chemosphere.2019.04.191 |
container_title |
Chemosphere |
container_volume |
229 |
container_start_page |
549 |
op_container_end_page |
558 |
_version_ |
1802642811132051456 |