Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec
BACKGROUND: Perfluoroalkyl substances (PFASs) are found in several consumer goods. Exposure to PFASs in children has been associated with alteration in thyroid hormones, which have critical roles in brain function. OBJECTIVE: In 2015, 198 children and youth (3-19 y) were recruited as part of the pil...
Published in: | Environment International |
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Elsevier Ltd
2020
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Online Access: | https://hdl.handle.net/20.500.11794/38376 https://doi.org/10.1016/j.envint.2019.04.029 |
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ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/38376 2024-09-09T19:00:47+00:00 Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec Caron-Beaudoin, Élyse Lemire, Mélanie Anassour-Laouan Sidi, Elhadji Ayotte, Pierre Gros-Louis McHugh, Nancy Community of Lac Simon Community of Winneway–LongPoint First Nation CSSS Tshukuminu Kanani of Nutashkuan Community of Unamen Shipu Québec (Province) 2020-03-26T14:00:42Z application/pdf https://hdl.handle.net/20.500.11794/38376 https://doi.org/10.1016/j.envint.2019.04.029 eng eng Elsevier Ltd 0160-4120 http://hdl.handle.net/20.500.11794/38376 doi:10.1016/j.envint.2019.04.029 31029975 http://purl.org/coar/access_right/c_abf2 Perfluoroalkyl substances Perfluorononanoic acid Thyroid hormones Indigenous communities Composés organiques fluorés Hormones thyroïdiennes Enfants indiens d'Amérique -- Santé et hygiène article de recherche COAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche 2020 ftunivlavalcorp https://doi.org/20.500.11794/3837610.1016/j.envint.2019.04.029 2024-06-17T23:42:35Z BACKGROUND: Perfluoroalkyl substances (PFASs) are found in several consumer goods. Exposure to PFASs in children has been associated with alteration in thyroid hormones, which have critical roles in brain function. OBJECTIVE: In 2015, 198 children and youth (3-19 y) were recruited as part of the pilot project Jeunes, Environnement et Santé/Youth, Environment and Health (JES!-YEH!), realized in collaboration with four First Nation communities in Quebec. We aimed to evaluate serum concentrations of PFASs in relation to concentrations of thyroid-stimulating hormone (TSH), free thyroxine (T4) and thyroglobulin while adjusting for relevant confounders. METHODS: PFASs (PFOS, PFOA, PFHxS, PFNA), 2,2',4,4'-Tetrabromodiphenyl ether (PBDE-47) thyroid parameters (TSH, free T4, and thyroglobulin) were measured in serum samples of 186 participants. Iodine, creatinine, and cotinine were measured in urine samples. Serum levels of PFASs were compared to those measured in the general Canadian population and elsewhere. Multivariate regression analyses were performed to determine associations between PFASs and TSH, free T4 and thyroglobulin. RESULTS: PFOS, PFOA and PFHxS serum concentrations were low. However, PFNA concentrations among participants aged 12 to 19 years old from Anishinabe communities were three times higher than those measured in the Canadian Health Measures Survey (2009-2011) for the same age group (Geometric Means: 3.01 μg/L and 0.71 μg/L, respectively) and were particularly higher in the Anishinabe participants aged 6 to 11 years old (GM: 9.44 μg/L). Few participants had levels of TSH, free T4, and thyroglobulin outside age-specific paediatric ranges. When adjusted for relevant covariates and other contaminants, PFNA serum concentrations were positively associated with free T4 levels (Adjusted β = 0.36; p = 0.0014), but not with TSH and thyroglobulin levels. No association was observed between the other PFAS and thyroid hormones parameters. CONCLUSION: This pilot project reveals among the highest exposure to ... Other/Unknown Material anishina* Université Laval: CorpusUL Environment International 128 13 23 |
institution |
Open Polar |
collection |
Université Laval: CorpusUL |
op_collection_id |
ftunivlavalcorp |
language |
English |
topic |
Perfluoroalkyl substances Perfluorononanoic acid Thyroid hormones Indigenous communities Composés organiques fluorés Hormones thyroïdiennes Enfants indiens d'Amérique -- Santé et hygiène |
spellingShingle |
Perfluoroalkyl substances Perfluorononanoic acid Thyroid hormones Indigenous communities Composés organiques fluorés Hormones thyroïdiennes Enfants indiens d'Amérique -- Santé et hygiène Caron-Beaudoin, Élyse Lemire, Mélanie Anassour-Laouan Sidi, Elhadji Ayotte, Pierre Gros-Louis McHugh, Nancy Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec |
topic_facet |
Perfluoroalkyl substances Perfluorononanoic acid Thyroid hormones Indigenous communities Composés organiques fluorés Hormones thyroïdiennes Enfants indiens d'Amérique -- Santé et hygiène |
description |
BACKGROUND: Perfluoroalkyl substances (PFASs) are found in several consumer goods. Exposure to PFASs in children has been associated with alteration in thyroid hormones, which have critical roles in brain function. OBJECTIVE: In 2015, 198 children and youth (3-19 y) were recruited as part of the pilot project Jeunes, Environnement et Santé/Youth, Environment and Health (JES!-YEH!), realized in collaboration with four First Nation communities in Quebec. We aimed to evaluate serum concentrations of PFASs in relation to concentrations of thyroid-stimulating hormone (TSH), free thyroxine (T4) and thyroglobulin while adjusting for relevant confounders. METHODS: PFASs (PFOS, PFOA, PFHxS, PFNA), 2,2',4,4'-Tetrabromodiphenyl ether (PBDE-47) thyroid parameters (TSH, free T4, and thyroglobulin) were measured in serum samples of 186 participants. Iodine, creatinine, and cotinine were measured in urine samples. Serum levels of PFASs were compared to those measured in the general Canadian population and elsewhere. Multivariate regression analyses were performed to determine associations between PFASs and TSH, free T4 and thyroglobulin. RESULTS: PFOS, PFOA and PFHxS serum concentrations were low. However, PFNA concentrations among participants aged 12 to 19 years old from Anishinabe communities were three times higher than those measured in the Canadian Health Measures Survey (2009-2011) for the same age group (Geometric Means: 3.01 μg/L and 0.71 μg/L, respectively) and were particularly higher in the Anishinabe participants aged 6 to 11 years old (GM: 9.44 μg/L). Few participants had levels of TSH, free T4, and thyroglobulin outside age-specific paediatric ranges. When adjusted for relevant covariates and other contaminants, PFNA serum concentrations were positively associated with free T4 levels (Adjusted β = 0.36; p = 0.0014), but not with TSH and thyroglobulin levels. No association was observed between the other PFAS and thyroid hormones parameters. CONCLUSION: This pilot project reveals among the highest exposure to ... |
author2 |
Community of Lac Simon Community of Winneway–LongPoint First Nation CSSS Tshukuminu Kanani of Nutashkuan Community of Unamen Shipu |
format |
Other/Unknown Material |
author |
Caron-Beaudoin, Élyse Lemire, Mélanie Anassour-Laouan Sidi, Elhadji Ayotte, Pierre Gros-Louis McHugh, Nancy |
author_facet |
Caron-Beaudoin, Élyse Lemire, Mélanie Anassour-Laouan Sidi, Elhadji Ayotte, Pierre Gros-Louis McHugh, Nancy |
author_sort |
Caron-Beaudoin, Élyse |
title |
Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec |
title_short |
Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec |
title_full |
Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec |
title_fullStr |
Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec |
title_full_unstemmed |
Exposure to perfluoroalkyl substances (PFAS) and associations with thyroid parameters in First Nation children and youth from Quebec |
title_sort |
exposure to perfluoroalkyl substances (pfas) and associations with thyroid parameters in first nation children and youth from quebec |
publisher |
Elsevier Ltd |
publishDate |
2020 |
url |
https://hdl.handle.net/20.500.11794/38376 https://doi.org/10.1016/j.envint.2019.04.029 |
op_coverage |
Québec (Province) |
genre |
anishina* |
genre_facet |
anishina* |
op_relation |
0160-4120 http://hdl.handle.net/20.500.11794/38376 doi:10.1016/j.envint.2019.04.029 31029975 |
op_rights |
http://purl.org/coar/access_right/c_abf2 |
op_doi |
https://doi.org/20.500.11794/3837610.1016/j.envint.2019.04.029 |
container_title |
Environment International |
container_volume |
128 |
container_start_page |
13 |
op_container_end_page |
23 |
_version_ |
1809942033937203200 |