Determinants of selenoneine concentration in red blood cells of Inuit from Nunavik (Northern Québec, Canada)
Selenium (Se) is a trace mineral essential to human health, and is especially abundant in marine foods consumed by Inuit populations in Nunavik (northern Quebec, Canada), leading to exceptionally high whole blood Se levels. While most epidemiological studies to date examine plasma or whole blood Se,...
Published in: | Environment International |
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Language: | English |
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Elsevier Inc.
2020
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Online Access: | https://hdl.handle.net/20.500.11794/38343 https://doi.org/10.1016/j.envint.2018.11.077 |
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ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/38343 2024-06-23T07:50:54+00:00 Determinants of selenoneine concentration in red blood cells of Inuit from Nunavik (Northern Québec, Canada) Lemire, Mélanie Little, Matthew Achouba, Adel Ayotte, Pierre Dumas, Marie-Pierre Ouellet, Nathalie Nunavik (Québec) 2020-03-26T15:21:03Z application/pdf https://hdl.handle.net/20.500.11794/38343 https://doi.org/10.1016/j.envint.2018.11.077 eng eng Elsevier Inc. 0160-4120 http://hdl.handle.net/20.500.11794/38343 doi:10.1016/j.envint.2018.11.077 30928848 http://purl.org/coar/access_right/c_abf2 Arctic Marine country foods Inuit Selenium Mercury Selenoneine Sélénium -- Composés Inuits -- Alimentation Inuits -- Santé et hygiène Érythrocytes Gibier (Aliment) article de recherche COAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche 2020 ftunivlavalcorp https://doi.org/20.500.11794/3834310.1016/j.envint.2018.11.077 2024-06-03T23:43:59Z Selenium (Se) is a trace mineral essential to human health, and is especially abundant in marine foods consumed by Inuit populations in Nunavik (northern Quebec, Canada), leading to exceptionally high whole blood Se levels. While most epidemiological studies to date examine plasma or whole blood Se, little is known about the health implications of specific Se biomarkers (e.g. selenoproteins and small Se compounds). Selenoneine, a novel Se compound, is found in high concentrations in marine foods (and particularly beluga mattaaq) and the red blood cells (RBCs) of populations that consume them. We report here RBC selenoneine concentrations in a population of Inuit adults (n = 885) who participated in the Qanuippitaa? 2004 survey. Simple associations between RBC selenoneine and other Se and mercury (Hg) biomarkers were assessed using Spearman correlations and linear regressions. Wilcoxon ranksum tests were used to examine differences in biomarkers and characteristics between tertiles of RBC selenoneine concentration. A multiple linear regression analysis was used to determine factors (sociodemographic, lifestyle, and dietary) associated with RBC selenoneine concentrations. Selenoneine comprised a large proportion of whole blood Se and RBC Se in this population. Age and sex-adjusted geometric mean RBC selenoneine concentration was 118 μg/L (range: 1-3226 μg/L) and was much higher (p = 0.001) among women (150.3 μg/L) than men (87.6 μg/L) across all regions of Nunavik after controlling for age, region, and diet. RBC selenoneine was highly correlated with RBC Se (rs = 0.96, p < 0.001) and whole blood Se (rs = 0.89, p < 0.001), but only weakly correlated with plasma Se (rs = 0.13, p < 0.001). Overall, increasing age (standardized β = 0.24), higher body-mass index (BMI; β = 0.08), female sex (β = 0.10), living in a Hudson Strait community (compared to Hudson Bay and Ungava Bay; β = 0.38), and consuming beluga mattaaq (g/day; β = 0.19) were positively associated with RBC selenoneine. Meanwhile, consumption of ... Other/Unknown Material Arctic Beluga Beluga* Hudson Bay Hudson Strait Human health inuit inuits Ungava Bay Nunavik Université Laval: CorpusUL Arctic Canada Hudson Hudson Bay Hudson Strait ENVELOPE(-70.000,-70.000,62.000,62.000) Nunavik Ungava Bay ENVELOPE(-67.489,-67.489,59.498,59.498) Environment International 127 243 252 |
institution |
Open Polar |
collection |
Université Laval: CorpusUL |
op_collection_id |
ftunivlavalcorp |
language |
English |
topic |
Arctic Marine country foods Inuit Selenium Mercury Selenoneine Sélénium -- Composés Inuits -- Alimentation Inuits -- Santé et hygiène Érythrocytes Gibier (Aliment) |
spellingShingle |
Arctic Marine country foods Inuit Selenium Mercury Selenoneine Sélénium -- Composés Inuits -- Alimentation Inuits -- Santé et hygiène Érythrocytes Gibier (Aliment) Lemire, Mélanie Little, Matthew Achouba, Adel Ayotte, Pierre Dumas, Marie-Pierre Ouellet, Nathalie Determinants of selenoneine concentration in red blood cells of Inuit from Nunavik (Northern Québec, Canada) |
topic_facet |
Arctic Marine country foods Inuit Selenium Mercury Selenoneine Sélénium -- Composés Inuits -- Alimentation Inuits -- Santé et hygiène Érythrocytes Gibier (Aliment) |
description |
Selenium (Se) is a trace mineral essential to human health, and is especially abundant in marine foods consumed by Inuit populations in Nunavik (northern Quebec, Canada), leading to exceptionally high whole blood Se levels. While most epidemiological studies to date examine plasma or whole blood Se, little is known about the health implications of specific Se biomarkers (e.g. selenoproteins and small Se compounds). Selenoneine, a novel Se compound, is found in high concentrations in marine foods (and particularly beluga mattaaq) and the red blood cells (RBCs) of populations that consume them. We report here RBC selenoneine concentrations in a population of Inuit adults (n = 885) who participated in the Qanuippitaa? 2004 survey. Simple associations between RBC selenoneine and other Se and mercury (Hg) biomarkers were assessed using Spearman correlations and linear regressions. Wilcoxon ranksum tests were used to examine differences in biomarkers and characteristics between tertiles of RBC selenoneine concentration. A multiple linear regression analysis was used to determine factors (sociodemographic, lifestyle, and dietary) associated with RBC selenoneine concentrations. Selenoneine comprised a large proportion of whole blood Se and RBC Se in this population. Age and sex-adjusted geometric mean RBC selenoneine concentration was 118 μg/L (range: 1-3226 μg/L) and was much higher (p = 0.001) among women (150.3 μg/L) than men (87.6 μg/L) across all regions of Nunavik after controlling for age, region, and diet. RBC selenoneine was highly correlated with RBC Se (rs = 0.96, p < 0.001) and whole blood Se (rs = 0.89, p < 0.001), but only weakly correlated with plasma Se (rs = 0.13, p < 0.001). Overall, increasing age (standardized β = 0.24), higher body-mass index (BMI; β = 0.08), female sex (β = 0.10), living in a Hudson Strait community (compared to Hudson Bay and Ungava Bay; β = 0.38), and consuming beluga mattaaq (g/day; β = 0.19) were positively associated with RBC selenoneine. Meanwhile, consumption of ... |
format |
Other/Unknown Material |
author |
Lemire, Mélanie Little, Matthew Achouba, Adel Ayotte, Pierre Dumas, Marie-Pierre Ouellet, Nathalie |
author_facet |
Lemire, Mélanie Little, Matthew Achouba, Adel Ayotte, Pierre Dumas, Marie-Pierre Ouellet, Nathalie |
author_sort |
Lemire, Mélanie |
title |
Determinants of selenoneine concentration in red blood cells of Inuit from Nunavik (Northern Québec, Canada) |
title_short |
Determinants of selenoneine concentration in red blood cells of Inuit from Nunavik (Northern Québec, Canada) |
title_full |
Determinants of selenoneine concentration in red blood cells of Inuit from Nunavik (Northern Québec, Canada) |
title_fullStr |
Determinants of selenoneine concentration in red blood cells of Inuit from Nunavik (Northern Québec, Canada) |
title_full_unstemmed |
Determinants of selenoneine concentration in red blood cells of Inuit from Nunavik (Northern Québec, Canada) |
title_sort |
determinants of selenoneine concentration in red blood cells of inuit from nunavik (northern québec, canada) |
publisher |
Elsevier Inc. |
publishDate |
2020 |
url |
https://hdl.handle.net/20.500.11794/38343 https://doi.org/10.1016/j.envint.2018.11.077 |
op_coverage |
Nunavik (Québec) |
long_lat |
ENVELOPE(-70.000,-70.000,62.000,62.000) ENVELOPE(-67.489,-67.489,59.498,59.498) |
geographic |
Arctic Canada Hudson Hudson Bay Hudson Strait Nunavik Ungava Bay |
geographic_facet |
Arctic Canada Hudson Hudson Bay Hudson Strait Nunavik Ungava Bay |
genre |
Arctic Beluga Beluga* Hudson Bay Hudson Strait Human health inuit inuits Ungava Bay Nunavik |
genre_facet |
Arctic Beluga Beluga* Hudson Bay Hudson Strait Human health inuit inuits Ungava Bay Nunavik |
op_relation |
0160-4120 http://hdl.handle.net/20.500.11794/38343 doi:10.1016/j.envint.2018.11.077 30928848 |
op_rights |
http://purl.org/coar/access_right/c_abf2 |
op_doi |
https://doi.org/20.500.11794/3834310.1016/j.envint.2018.11.077 |
container_title |
Environment International |
container_volume |
127 |
container_start_page |
243 |
op_container_end_page |
252 |
_version_ |
1802641846276456448 |