Cardiometabolic health and per and polyfluoroalkyl substances in an Inuit population
Introduction: The cardiometabolic health status of Inuit in Nunavik has worsened in the last thirty years. The high concentrations of perfluoroalkyl acids (PFAAs) may be contributing to this since PFAAs have been linked with hypercholesterolemia, diabetes, and high blood pressure. The aim of this st...
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2024
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ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/135643 2024-06-23T07:50:52+00:00 Cardiometabolic health and per and polyfluoroalkyl substances in an Inuit population Aker, Amira Ayotte, Pierre Caron-Beaudoin, Élyse Ricard, Sylvie Gaudreau, Éric Lemire, Mélanie Québec (Province) -- Nunavik 2024-02-12T15:11:15Z application/pdf https://hdl.handle.net/20.500.11794/135643 https://doi.org/10.1016/j.envint.2023.108283 eng eng Elsevier Ltd 0160-4120 http://hdl.handle.net/20.500.11794/135643 doi:10.1016/j.envint.2023.108283 37883911 http://purl.org/coar/access_right/c_abf2 PFAS Cardiometabolic health Cholesterol Diabetes Blood pressure Inuit Indigenous Pression artérielle Condition cardiovasculaire Composés perfluorés -- Aspect sanitaire Cholestérol Diabète de type 2 Prédiabète Inuits -- Santé et hygiène article de recherche article 2024 ftunivlavalcorp https://doi.org/20.500.11794/13564310.1016/j.envint.2023.108283 2024-06-10T23:42:53Z Introduction: The cardiometabolic health status of Inuit in Nunavik has worsened in the last thirty years. The high concentrations of perfluoroalkyl acids (PFAAs) may be contributing to this since PFAAs have been linked with hypercholesterolemia, diabetes, and high blood pressure. The aim of this study was to examine the association between a PFAAs mixture and lipid profiles, Type II diabetes, prediabetes, and high blood pressure in this Inuit population. Methods: We included 1212 participants of the Qanuilirpitaa? 2017 survey aged 16–80 years. Two mixture models (quantile g-computation and Bayesian Kernel Machine Regression (BKMR)) were used to investigate the associations between six PFAAs (PFHxS, PFOS, PFOA and three long-chain PFAAs (PFNA, PFDA and PFUnDA)) with five lipid profiles and three cardiometabolic outcomes. Non-linearity and interaction between PFAAs were further assessed. Results: An IQR increase in all PFAAs congeners resulted in an increase in total cholesterol (β 0.15, 95% confidence interval (CI) 0.06, 0.24), low-density lipoprotein cholesterol (LDL) (β 0.08, 95% CI 0.01, 0.16), highdensity lipoprotein cholesterol (HDL) (β 0.04, 95% CI 0.002, 0.08), apolipoprotein B-100 (β 0.03, 95% CI 0.004, 0.05), and prediabetes (OR 1.80, 95% CI 1.11, 2.91). There was no association between PFAAs and triglycerides, diabetes, or high blood pressure. Long-chain PFAAs congeners were the main contributors driving the associations. Associations were largely linear, and there was no evidence of interaction between the PFAAs congeners. Conclusions: Our study provides further evidence of increasing circulating lipids with increased exposure to PFAAs. The increased risk of prediabetes points to the influence of PFAAs on potential clinical outcomes. International regulation of PFAAs is essential to curb PFAAs exposure and related health effects in Arctic communities. Article in Journal/Newspaper Arctic inuit inuits Nunavik Université Laval: CorpusUL Arctic Nunavik Environment International 181 108283 |
institution |
Open Polar |
collection |
Université Laval: CorpusUL |
op_collection_id |
ftunivlavalcorp |
language |
English |
topic |
PFAS Cardiometabolic health Cholesterol Diabetes Blood pressure Inuit Indigenous Pression artérielle Condition cardiovasculaire Composés perfluorés -- Aspect sanitaire Cholestérol Diabète de type 2 Prédiabète Inuits -- Santé et hygiène |
spellingShingle |
PFAS Cardiometabolic health Cholesterol Diabetes Blood pressure Inuit Indigenous Pression artérielle Condition cardiovasculaire Composés perfluorés -- Aspect sanitaire Cholestérol Diabète de type 2 Prédiabète Inuits -- Santé et hygiène Aker, Amira Ayotte, Pierre Caron-Beaudoin, Élyse Ricard, Sylvie Gaudreau, Éric Lemire, Mélanie Cardiometabolic health and per and polyfluoroalkyl substances in an Inuit population |
topic_facet |
PFAS Cardiometabolic health Cholesterol Diabetes Blood pressure Inuit Indigenous Pression artérielle Condition cardiovasculaire Composés perfluorés -- Aspect sanitaire Cholestérol Diabète de type 2 Prédiabète Inuits -- Santé et hygiène |
description |
Introduction: The cardiometabolic health status of Inuit in Nunavik has worsened in the last thirty years. The high concentrations of perfluoroalkyl acids (PFAAs) may be contributing to this since PFAAs have been linked with hypercholesterolemia, diabetes, and high blood pressure. The aim of this study was to examine the association between a PFAAs mixture and lipid profiles, Type II diabetes, prediabetes, and high blood pressure in this Inuit population. Methods: We included 1212 participants of the Qanuilirpitaa? 2017 survey aged 16–80 years. Two mixture models (quantile g-computation and Bayesian Kernel Machine Regression (BKMR)) were used to investigate the associations between six PFAAs (PFHxS, PFOS, PFOA and three long-chain PFAAs (PFNA, PFDA and PFUnDA)) with five lipid profiles and three cardiometabolic outcomes. Non-linearity and interaction between PFAAs were further assessed. Results: An IQR increase in all PFAAs congeners resulted in an increase in total cholesterol (β 0.15, 95% confidence interval (CI) 0.06, 0.24), low-density lipoprotein cholesterol (LDL) (β 0.08, 95% CI 0.01, 0.16), highdensity lipoprotein cholesterol (HDL) (β 0.04, 95% CI 0.002, 0.08), apolipoprotein B-100 (β 0.03, 95% CI 0.004, 0.05), and prediabetes (OR 1.80, 95% CI 1.11, 2.91). There was no association between PFAAs and triglycerides, diabetes, or high blood pressure. Long-chain PFAAs congeners were the main contributors driving the associations. Associations were largely linear, and there was no evidence of interaction between the PFAAs congeners. Conclusions: Our study provides further evidence of increasing circulating lipids with increased exposure to PFAAs. The increased risk of prediabetes points to the influence of PFAAs on potential clinical outcomes. International regulation of PFAAs is essential to curb PFAAs exposure and related health effects in Arctic communities. |
format |
Article in Journal/Newspaper |
author |
Aker, Amira Ayotte, Pierre Caron-Beaudoin, Élyse Ricard, Sylvie Gaudreau, Éric Lemire, Mélanie |
author_facet |
Aker, Amira Ayotte, Pierre Caron-Beaudoin, Élyse Ricard, Sylvie Gaudreau, Éric Lemire, Mélanie |
author_sort |
Aker, Amira |
title |
Cardiometabolic health and per and polyfluoroalkyl substances in an Inuit population |
title_short |
Cardiometabolic health and per and polyfluoroalkyl substances in an Inuit population |
title_full |
Cardiometabolic health and per and polyfluoroalkyl substances in an Inuit population |
title_fullStr |
Cardiometabolic health and per and polyfluoroalkyl substances in an Inuit population |
title_full_unstemmed |
Cardiometabolic health and per and polyfluoroalkyl substances in an Inuit population |
title_sort |
cardiometabolic health and per and polyfluoroalkyl substances in an inuit population |
publisher |
Elsevier Ltd |
publishDate |
2024 |
url |
https://hdl.handle.net/20.500.11794/135643 https://doi.org/10.1016/j.envint.2023.108283 |
op_coverage |
Québec (Province) -- Nunavik |
geographic |
Arctic Nunavik |
geographic_facet |
Arctic Nunavik |
genre |
Arctic inuit inuits Nunavik |
genre_facet |
Arctic inuit inuits Nunavik |
op_relation |
0160-4120 http://hdl.handle.net/20.500.11794/135643 doi:10.1016/j.envint.2023.108283 37883911 |
op_rights |
http://purl.org/coar/access_right/c_abf2 |
op_doi |
https://doi.org/20.500.11794/13564310.1016/j.envint.2023.108283 |
container_title |
Environment International |
container_volume |
181 |
container_start_page |
108283 |
_version_ |
1802641804639600640 |