Chemical composition and antiplasmodial activity of the essential oil of rhododendron subarcticum leaves from Nunavik, Québec, ́Canada
Dwarf Labrador tea, Rhododendron subarcticum Harmaja, is a popular medicinal plant in use by First Nations of Northern Canada, but its phytochemistry has remained largely unexplored. We have isolated and characterized the essential oil from a population of this species harvested near the treeline in...
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American Chemical Society
2023
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ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/120643 2024-09-09T19:40:31+00:00 Chemical composition and antiplasmodial activity of the essential oil of rhododendron subarcticum leaves from Nunavik, Québec, ́Canada Séguin, Jean-Christophe Gagnon, Dominic Bélanger, Sarah Richard, Dave Fernandez, Xavier Boudreau, Stéphane Voyer, Normand Québec (Province) -- Nunavik 2023-07-03T17:04:21Z application/pdf https://hdl.handle.net/20.500.11794/120643 https://doi.org/10.1021/acsomega.3c00235 eng eng American Chemical Society 2470-1343 http://hdl.handle.net/20.500.11794/120643 https://doi.org/10.1021/acsomega.3c00235 37214733 http://purl.org/coar/access_right/c_abf2 Rhododendrons -- Analyse Ledum -- Analyse Huiles essentielles article de recherche 2023 ftunivlavalcorp https://doi.org/20.500.11794/12064310.1021/acsomega.3c00235 2024-06-17T23:42:35Z Dwarf Labrador tea, Rhododendron subarcticum Harmaja, is a popular medicinal plant in use by First Nations of Northern Canada, but its phytochemistry has remained largely unexplored. We have isolated and characterized the essential oil from a population of this species harvested near the treeline in Nunavik, Québec. Analyses by gas chromatography–mass spectrometry (GC–MS) and gas chromatography/flame-ionization detection (GC/FID) led to the identification of 53 compounds; the main secondary metabolites were ascaridole (64.7% of the total FID area) and p-cymene (21.1%). Such a composition resembles a chemotype observed for R. tomentosum, a close relative found mainly in Europe and Asia, but has never been attributed to R. subarcticum. Growth inhibition assays against different strains of Plasmodium falciparum (3D7, Dd2), the parasite responsible for the most severe form of malaria, were conducted with either the R. subarcticum’s essential oil or the isolated ascaridole. Our results show that the essential oil’s biological activity can be attributed to ascaridole as its IC50 is more than twice that of ascaridole [ascaridole’s IC50 values are 147.3 nM (3D7) and 104.9 nM (Dd2)]. Other/Unknown Material First Nations Nunavik Université Laval: CorpusUL Canada Fid ENVELOPE(-65.939,-65.939,-68.664,-68.664) Nunavik ACS Omega 8 19 16729 16737 |
institution |
Open Polar |
collection |
Université Laval: CorpusUL |
op_collection_id |
ftunivlavalcorp |
language |
English |
topic |
Rhododendrons -- Analyse Ledum -- Analyse Huiles essentielles |
spellingShingle |
Rhododendrons -- Analyse Ledum -- Analyse Huiles essentielles Séguin, Jean-Christophe Gagnon, Dominic Bélanger, Sarah Richard, Dave Fernandez, Xavier Boudreau, Stéphane Voyer, Normand Chemical composition and antiplasmodial activity of the essential oil of rhododendron subarcticum leaves from Nunavik, Québec, ́Canada |
topic_facet |
Rhododendrons -- Analyse Ledum -- Analyse Huiles essentielles |
description |
Dwarf Labrador tea, Rhododendron subarcticum Harmaja, is a popular medicinal plant in use by First Nations of Northern Canada, but its phytochemistry has remained largely unexplored. We have isolated and characterized the essential oil from a population of this species harvested near the treeline in Nunavik, Québec. Analyses by gas chromatography–mass spectrometry (GC–MS) and gas chromatography/flame-ionization detection (GC/FID) led to the identification of 53 compounds; the main secondary metabolites were ascaridole (64.7% of the total FID area) and p-cymene (21.1%). Such a composition resembles a chemotype observed for R. tomentosum, a close relative found mainly in Europe and Asia, but has never been attributed to R. subarcticum. Growth inhibition assays against different strains of Plasmodium falciparum (3D7, Dd2), the parasite responsible for the most severe form of malaria, were conducted with either the R. subarcticum’s essential oil or the isolated ascaridole. Our results show that the essential oil’s biological activity can be attributed to ascaridole as its IC50 is more than twice that of ascaridole [ascaridole’s IC50 values are 147.3 nM (3D7) and 104.9 nM (Dd2)]. |
format |
Other/Unknown Material |
author |
Séguin, Jean-Christophe Gagnon, Dominic Bélanger, Sarah Richard, Dave Fernandez, Xavier Boudreau, Stéphane Voyer, Normand |
author_facet |
Séguin, Jean-Christophe Gagnon, Dominic Bélanger, Sarah Richard, Dave Fernandez, Xavier Boudreau, Stéphane Voyer, Normand |
author_sort |
Séguin, Jean-Christophe |
title |
Chemical composition and antiplasmodial activity of the essential oil of rhododendron subarcticum leaves from Nunavik, Québec, ́Canada |
title_short |
Chemical composition and antiplasmodial activity of the essential oil of rhododendron subarcticum leaves from Nunavik, Québec, ́Canada |
title_full |
Chemical composition and antiplasmodial activity of the essential oil of rhododendron subarcticum leaves from Nunavik, Québec, ́Canada |
title_fullStr |
Chemical composition and antiplasmodial activity of the essential oil of rhododendron subarcticum leaves from Nunavik, Québec, ́Canada |
title_full_unstemmed |
Chemical composition and antiplasmodial activity of the essential oil of rhododendron subarcticum leaves from Nunavik, Québec, ́Canada |
title_sort |
chemical composition and antiplasmodial activity of the essential oil of rhododendron subarcticum leaves from nunavik, québec, ́canada |
publisher |
American Chemical Society |
publishDate |
2023 |
url |
https://hdl.handle.net/20.500.11794/120643 https://doi.org/10.1021/acsomega.3c00235 |
op_coverage |
Québec (Province) -- Nunavik |
long_lat |
ENVELOPE(-65.939,-65.939,-68.664,-68.664) |
geographic |
Canada Fid Nunavik |
geographic_facet |
Canada Fid Nunavik |
genre |
First Nations Nunavik |
genre_facet |
First Nations Nunavik |
op_relation |
2470-1343 http://hdl.handle.net/20.500.11794/120643 https://doi.org/10.1021/acsomega.3c00235 37214733 |
op_rights |
http://purl.org/coar/access_right/c_abf2 |
op_doi |
https://doi.org/20.500.11794/12064310.1021/acsomega.3c00235 |
container_title |
ACS Omega |
container_volume |
8 |
container_issue |
19 |
container_start_page |
16729 |
op_container_end_page |
16737 |
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1809909854424268800 |