Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers
Background: Whereas it is well established that prenatal exposure to polychlorinated biphenyls (PCBs) can disrupt children's behavior, early postnatal exposure has received relatively little attention in environmental epidemiology. Objectives: To evaluate prenatal and postnatal exposures to PCB...
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2016
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ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/11928 2024-06-23T07:54:12+00:00 Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers Verner, Marc-André Ayotte, Pierre Plusquellec, Pierrich Muckle, Gina Desjardins, Justine Dewailly, Éric Cartier, Chloé Nunavik (Québec) 2016-10-28T13:25:50Z application/pdf https://hdl.handle.net/20.500.11794/11928 https://doi.org/10.1016/j.envint.2015.02.004 eng eng Pergamon 0160-4120 http://hdl.handle.net/20.500.11794/11928 doi:10.1016/j.envint.2015.02.004 25796081 http://purl.org/coar/access_right/c_abf2 Polychlorinated biphenyls (PCBs) Behavior Preschoolers Pharmacokinetic modeling Postnatal exposure Biphényles polychlorés -- Effets physiologiques Inuits -- Santé et hygiène Enfants d'âge préscolaire -- Santé et hygiène Pharmacocinétique article de recherche COAR1_1::Texte::Périodique::Revue::Contribution à un journal::Article::Article de recherche 2016 ftunivlavalcorp https://doi.org/20.500.11794/1192810.1016/j.envint.2015.02.004 2024-06-10T23:42:53Z Background: Whereas it is well established that prenatal exposure to polychlorinated biphenyls (PCBs) can disrupt children's behavior, early postnatal exposure has received relatively little attention in environmental epidemiology. Objectives: To evaluate prenatal and postnatal exposures to PCB-153, a proxy of total PCB exposure, and their relation to inattention and activity in 5-year-old Inuits from the Cord Blood Monitoring Program. Methods: Prenatal exposure to PCBs was informed by cord plasma PCB-153 levels. We used a validated pharmacokinetic model to estimate monthly infants' levels across the first year of life. Inattention and activity were assessed by coding of video recordings of children undergoing fine motor testing. We used multivariable linear regression to evaluate the association between prenatal and postnatal PCB-153 levels and inattention (n=97) and activity (n=98) at 5years of age. Results: Cord plasma PCB-153 was not associated with inattention and activity. Each interquartile range (IQR) increase in estimated infant PCB-153 levels at 2months was associated with a 1.02% increase in the duration of inattention (95% CI: 0.04, 2.00). Statistical adjustment for the duration of breastfeeding slightly increased regression coefficients for postnatal level estimates, some of which became statistically significant for inattention (months: 2-4) and activity (months: 2-5). Conclusions: Our study adds to the growing evidence of postnatal windows of development during which children are more susceptible to neurotoxicants like PCBs. Other/Unknown Material inuit inuits Nunavik Université Laval: CorpusUL Nunavik Environment International 78 90 94 |
institution |
Open Polar |
collection |
Université Laval: CorpusUL |
op_collection_id |
ftunivlavalcorp |
language |
English |
topic |
Polychlorinated biphenyls (PCBs) Behavior Preschoolers Pharmacokinetic modeling Postnatal exposure Biphényles polychlorés -- Effets physiologiques Inuits -- Santé et hygiène Enfants d'âge préscolaire -- Santé et hygiène Pharmacocinétique |
spellingShingle |
Polychlorinated biphenyls (PCBs) Behavior Preschoolers Pharmacokinetic modeling Postnatal exposure Biphényles polychlorés -- Effets physiologiques Inuits -- Santé et hygiène Enfants d'âge préscolaire -- Santé et hygiène Pharmacocinétique Verner, Marc-André Ayotte, Pierre Plusquellec, Pierrich Muckle, Gina Desjardins, Justine Dewailly, Éric Cartier, Chloé Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers |
topic_facet |
Polychlorinated biphenyls (PCBs) Behavior Preschoolers Pharmacokinetic modeling Postnatal exposure Biphényles polychlorés -- Effets physiologiques Inuits -- Santé et hygiène Enfants d'âge préscolaire -- Santé et hygiène Pharmacocinétique |
description |
Background: Whereas it is well established that prenatal exposure to polychlorinated biphenyls (PCBs) can disrupt children's behavior, early postnatal exposure has received relatively little attention in environmental epidemiology. Objectives: To evaluate prenatal and postnatal exposures to PCB-153, a proxy of total PCB exposure, and their relation to inattention and activity in 5-year-old Inuits from the Cord Blood Monitoring Program. Methods: Prenatal exposure to PCBs was informed by cord plasma PCB-153 levels. We used a validated pharmacokinetic model to estimate monthly infants' levels across the first year of life. Inattention and activity were assessed by coding of video recordings of children undergoing fine motor testing. We used multivariable linear regression to evaluate the association between prenatal and postnatal PCB-153 levels and inattention (n=97) and activity (n=98) at 5years of age. Results: Cord plasma PCB-153 was not associated with inattention and activity. Each interquartile range (IQR) increase in estimated infant PCB-153 levels at 2months was associated with a 1.02% increase in the duration of inattention (95% CI: 0.04, 2.00). Statistical adjustment for the duration of breastfeeding slightly increased regression coefficients for postnatal level estimates, some of which became statistically significant for inattention (months: 2-4) and activity (months: 2-5). Conclusions: Our study adds to the growing evidence of postnatal windows of development during which children are more susceptible to neurotoxicants like PCBs. |
format |
Other/Unknown Material |
author |
Verner, Marc-André Ayotte, Pierre Plusquellec, Pierrich Muckle, Gina Desjardins, Justine Dewailly, Éric Cartier, Chloé |
author_facet |
Verner, Marc-André Ayotte, Pierre Plusquellec, Pierrich Muckle, Gina Desjardins, Justine Dewailly, Éric Cartier, Chloé |
author_sort |
Verner, Marc-André |
title |
Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers |
title_short |
Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers |
title_full |
Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers |
title_fullStr |
Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers |
title_full_unstemmed |
Prenatal and early-life polychlorinated biphenyl (PCB) levels and behavior in Inuit preschoolers |
title_sort |
prenatal and early-life polychlorinated biphenyl (pcb) levels and behavior in inuit preschoolers |
publisher |
Pergamon |
publishDate |
2016 |
url |
https://hdl.handle.net/20.500.11794/11928 https://doi.org/10.1016/j.envint.2015.02.004 |
op_coverage |
Nunavik (Québec) |
geographic |
Nunavik |
geographic_facet |
Nunavik |
genre |
inuit inuits Nunavik |
genre_facet |
inuit inuits Nunavik |
op_relation |
0160-4120 http://hdl.handle.net/20.500.11794/11928 doi:10.1016/j.envint.2015.02.004 25796081 |
op_rights |
http://purl.org/coar/access_right/c_abf2 |
op_doi |
https://doi.org/20.500.11794/1192810.1016/j.envint.2015.02.004 |
container_title |
Environment International |
container_volume |
78 |
container_start_page |
90 |
op_container_end_page |
94 |
_version_ |
1802646252408537088 |