Gut metagenome profile of the Nunavik Inuit youth is distinct from industrial and non-industrial counterparts
Comparative metagenomics studies have highlighted differences in microbiome community structure among human populations over diverse lifestyles and environments. With their unique environmental and historical backgrounds, Nunavik Inuit have a distinctive gut microbiome with undocumented health-relat...
Published in: | Communications Biology |
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Springer Nature
2023
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Online Access: | https://hdl.handle.net/20.500.11794/112385 https://doi.org/10.1038/s42003-022-04372-y |
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ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/112385 2024-06-23T07:54:10+00:00 Gut metagenome profile of the Nunavik Inuit youth is distinct from industrial and non-industrial counterparts Abed, Jehane Y. Godon, Thibaud Mehdaoui, Fadwa Plante, Pier-Luc Boissinot, Maurice Bergeron, Michel G. Bélanger, Richard E. Muckle, Gina Poliakova, Natalia Ayotte, Pierre Corbeil, Jacques Québec (Province) -- Nunavik 2023-02-27T14:10:00Z application/pdf https://hdl.handle.net/20.500.11794/112385 https://doi.org/10.1038/s42003-022-04372-y eng eng Springer Nature 2399-3642 http://hdl.handle.net/20.500.11794/112385 doi:10.1038/s42003-022-04372-y 36566300 http://purl.org/coar/access_right/c_abf2 Métagénomique Intestins -- Microbiologie Inuits article de recherche 2023 ftunivlavalcorp https://doi.org/20.500.11794/11238510.1038/s42003-022-04372-y 2024-06-10T23:42:53Z Comparative metagenomics studies have highlighted differences in microbiome community structure among human populations over diverse lifestyles and environments. With their unique environmental and historical backgrounds, Nunavik Inuit have a distinctive gut microbiome with undocumented health-related implications. Using shotgun metagenomics, we explored the taxonomic and functional structure of the gut microbiome from 275 Nunavik Inuit ranging from 16 to 30-year-old. Whole-metagenome analyses revealed that Nunavik Inuit youths have a more diverse microbiome than their non-industrialized and industrialized counterparts. A comparison of k-mer content illustrated the uniqueness of the Nunavik gut microbiome. Short-chain fatty acids producing species, and carbohydrates degradation pathways dominated Inuit metagenomes. We identified a taxonomic and functional signature unique to the Nunavik gut microbiome contrasting with other populations using a random forest classifier. Here, we show that the Nunavik Inuit gut microbiome exhibits high diversity and a distinct community structure. Other/Unknown Material inuit inuits Nunavik Université Laval: CorpusUL Nunavik Communications Biology 5 1 |
institution |
Open Polar |
collection |
Université Laval: CorpusUL |
op_collection_id |
ftunivlavalcorp |
language |
English |
topic |
Métagénomique Intestins -- Microbiologie Inuits |
spellingShingle |
Métagénomique Intestins -- Microbiologie Inuits Abed, Jehane Y. Godon, Thibaud Mehdaoui, Fadwa Plante, Pier-Luc Boissinot, Maurice Bergeron, Michel G. Bélanger, Richard E. Muckle, Gina Poliakova, Natalia Ayotte, Pierre Corbeil, Jacques Gut metagenome profile of the Nunavik Inuit youth is distinct from industrial and non-industrial counterparts |
topic_facet |
Métagénomique Intestins -- Microbiologie Inuits |
description |
Comparative metagenomics studies have highlighted differences in microbiome community structure among human populations over diverse lifestyles and environments. With their unique environmental and historical backgrounds, Nunavik Inuit have a distinctive gut microbiome with undocumented health-related implications. Using shotgun metagenomics, we explored the taxonomic and functional structure of the gut microbiome from 275 Nunavik Inuit ranging from 16 to 30-year-old. Whole-metagenome analyses revealed that Nunavik Inuit youths have a more diverse microbiome than their non-industrialized and industrialized counterparts. A comparison of k-mer content illustrated the uniqueness of the Nunavik gut microbiome. Short-chain fatty acids producing species, and carbohydrates degradation pathways dominated Inuit metagenomes. We identified a taxonomic and functional signature unique to the Nunavik gut microbiome contrasting with other populations using a random forest classifier. Here, we show that the Nunavik Inuit gut microbiome exhibits high diversity and a distinct community structure. |
format |
Other/Unknown Material |
author |
Abed, Jehane Y. Godon, Thibaud Mehdaoui, Fadwa Plante, Pier-Luc Boissinot, Maurice Bergeron, Michel G. Bélanger, Richard E. Muckle, Gina Poliakova, Natalia Ayotte, Pierre Corbeil, Jacques |
author_facet |
Abed, Jehane Y. Godon, Thibaud Mehdaoui, Fadwa Plante, Pier-Luc Boissinot, Maurice Bergeron, Michel G. Bélanger, Richard E. Muckle, Gina Poliakova, Natalia Ayotte, Pierre Corbeil, Jacques |
author_sort |
Abed, Jehane Y. |
title |
Gut metagenome profile of the Nunavik Inuit youth is distinct from industrial and non-industrial counterparts |
title_short |
Gut metagenome profile of the Nunavik Inuit youth is distinct from industrial and non-industrial counterparts |
title_full |
Gut metagenome profile of the Nunavik Inuit youth is distinct from industrial and non-industrial counterparts |
title_fullStr |
Gut metagenome profile of the Nunavik Inuit youth is distinct from industrial and non-industrial counterparts |
title_full_unstemmed |
Gut metagenome profile of the Nunavik Inuit youth is distinct from industrial and non-industrial counterparts |
title_sort |
gut metagenome profile of the nunavik inuit youth is distinct from industrial and non-industrial counterparts |
publisher |
Springer Nature |
publishDate |
2023 |
url |
https://hdl.handle.net/20.500.11794/112385 https://doi.org/10.1038/s42003-022-04372-y |
op_coverage |
Québec (Province) -- Nunavik |
geographic |
Nunavik |
geographic_facet |
Nunavik |
genre |
inuit inuits Nunavik |
genre_facet |
inuit inuits Nunavik |
op_relation |
2399-3642 http://hdl.handle.net/20.500.11794/112385 doi:10.1038/s42003-022-04372-y 36566300 |
op_rights |
http://purl.org/coar/access_right/c_abf2 |
op_doi |
https://doi.org/20.500.11794/11238510.1038/s42003-022-04372-y |
container_title |
Communications Biology |
container_volume |
5 |
container_issue |
1 |
_version_ |
1802646197034287104 |