Plasma concentrations of perfluoroalkyl acids and their determinants in youth and adults from Nunavik, Canada
Perfluoroalkyl acids (PFAAs), a subset of per- and poly-fluoroalkyl substances (PFAS), are environmentally stable, mobile and bioaccumulative compounds. This leads to high concentrations in wildlife species essential to the cultural identity and subsistence of Arctic populations. Our objective was t...
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ftunivlavalcorp:oai:corpus.ulaval.ca:20.500.11794/106463 2024-06-23T07:50:06+00:00 Plasma concentrations of perfluoroalkyl acids and their determinants in youth and adults from Nunavik, Canada Aker, Amira Ayotte, Pierre Caron-Beaudoin, Élyse Silva, Amila de Ricard, Sylvie Gaudreau, Éric Lemire, Mélanie Québec (Province) -- Nunavik 2022-12-12T20:11:35Z application/pdf https://hdl.handle.net/20.500.11794/106463 https://doi.org/10.1016/j.chemosphere.2022.136797 eng eng Pergamon 0045-6535 http://hdl.handle.net/20.500.11794/106463 doi:10.1016/j.chemosphere.2022.136797 http://purl.org/coar/access_right/c_abf2 Perfluoroalkyl acids PFAS Exposure determinants Inuit Arctic Indigenous Composés perfluorés Plasma Inuits article de recherche 2022 ftunivlavalcorp https://doi.org/20.500.11794/10646310.1016/j.chemosphere.2022.136797 2024-06-10T23:42:53Z Perfluoroalkyl acids (PFAAs), a subset of per- and poly-fluoroalkyl substances (PFAS), are environmentally stable, mobile and bioaccumulative compounds. This leads to high concentrations in wildlife species essential to the cultural identity and subsistence of Arctic populations. Our objective was to characterize the distribution and exposure determinants of PFAAs among Nunavik Inuit adults. The study included up to 1322 Nunavik residents aged 16–80 years who participated in the Qanuilirpitaa? 2017 Nunavik Inuit Health Survey (Q2017). Plasma concentrations were compared to those the general Canadian population using data from the Canadian Health Measures Survey Cycle 5 (2016–2017). Associations between plasma concentrations of nine PFAAs, determined by liquid chromatography-tandem mass spectrometry, and sociodemographic factors and traditional activity participation were examined using multiple linear regression models. Overall exposure to PFAAs was twice as high compared to the general Canadian population and less regulated perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUnDA) concentrations were 7-fold higher, and perfluorodecanoic acid (PFDA) concentrations were 4-fold higher. Males had higher concentrations of perfluorooctanoic acid (PFOA) and perfluorohexane sulfonate (PFHxS), whereas females had higher concentrations of PFDA and PFUnDA. PFAAs concentrations increased with age and were highest among those aged 60+ years. PFNA and PFOA Other/Unknown Material Arctic inuit inuits Nunavik Université Laval: CorpusUL Arctic Nunavik Canada Chemosphere 310 136797 |
institution |
Open Polar |
collection |
Université Laval: CorpusUL |
op_collection_id |
ftunivlavalcorp |
language |
English |
topic |
Perfluoroalkyl acids PFAS Exposure determinants Inuit Arctic Indigenous Composés perfluorés Plasma Inuits |
spellingShingle |
Perfluoroalkyl acids PFAS Exposure determinants Inuit Arctic Indigenous Composés perfluorés Plasma Inuits Aker, Amira Ayotte, Pierre Caron-Beaudoin, Élyse Silva, Amila de Ricard, Sylvie Gaudreau, Éric Lemire, Mélanie Plasma concentrations of perfluoroalkyl acids and their determinants in youth and adults from Nunavik, Canada |
topic_facet |
Perfluoroalkyl acids PFAS Exposure determinants Inuit Arctic Indigenous Composés perfluorés Plasma Inuits |
description |
Perfluoroalkyl acids (PFAAs), a subset of per- and poly-fluoroalkyl substances (PFAS), are environmentally stable, mobile and bioaccumulative compounds. This leads to high concentrations in wildlife species essential to the cultural identity and subsistence of Arctic populations. Our objective was to characterize the distribution and exposure determinants of PFAAs among Nunavik Inuit adults. The study included up to 1322 Nunavik residents aged 16–80 years who participated in the Qanuilirpitaa? 2017 Nunavik Inuit Health Survey (Q2017). Plasma concentrations were compared to those the general Canadian population using data from the Canadian Health Measures Survey Cycle 5 (2016–2017). Associations between plasma concentrations of nine PFAAs, determined by liquid chromatography-tandem mass spectrometry, and sociodemographic factors and traditional activity participation were examined using multiple linear regression models. Overall exposure to PFAAs was twice as high compared to the general Canadian population and less regulated perfluorononanoic acid (PFNA) and perfluoroundecanoic acid (PFUnDA) concentrations were 7-fold higher, and perfluorodecanoic acid (PFDA) concentrations were 4-fold higher. Males had higher concentrations of perfluorooctanoic acid (PFOA) and perfluorohexane sulfonate (PFHxS), whereas females had higher concentrations of PFDA and PFUnDA. PFAAs concentrations increased with age and were highest among those aged 60+ years. PFNA and PFOA |
format |
Other/Unknown Material |
author |
Aker, Amira Ayotte, Pierre Caron-Beaudoin, Élyse Silva, Amila de Ricard, Sylvie Gaudreau, Éric Lemire, Mélanie |
author_facet |
Aker, Amira Ayotte, Pierre Caron-Beaudoin, Élyse Silva, Amila de Ricard, Sylvie Gaudreau, Éric Lemire, Mélanie |
author_sort |
Aker, Amira |
title |
Plasma concentrations of perfluoroalkyl acids and their determinants in youth and adults from Nunavik, Canada |
title_short |
Plasma concentrations of perfluoroalkyl acids and their determinants in youth and adults from Nunavik, Canada |
title_full |
Plasma concentrations of perfluoroalkyl acids and their determinants in youth and adults from Nunavik, Canada |
title_fullStr |
Plasma concentrations of perfluoroalkyl acids and their determinants in youth and adults from Nunavik, Canada |
title_full_unstemmed |
Plasma concentrations of perfluoroalkyl acids and their determinants in youth and adults from Nunavik, Canada |
title_sort |
plasma concentrations of perfluoroalkyl acids and their determinants in youth and adults from nunavik, canada |
publisher |
Pergamon |
publishDate |
2022 |
url |
https://hdl.handle.net/20.500.11794/106463 https://doi.org/10.1016/j.chemosphere.2022.136797 |
op_coverage |
Québec (Province) -- Nunavik |
geographic |
Arctic Nunavik Canada |
geographic_facet |
Arctic Nunavik Canada |
genre |
Arctic inuit inuits Nunavik |
genre_facet |
Arctic inuit inuits Nunavik |
op_relation |
0045-6535 http://hdl.handle.net/20.500.11794/106463 doi:10.1016/j.chemosphere.2022.136797 |
op_rights |
http://purl.org/coar/access_right/c_abf2 |
op_doi |
https://doi.org/20.500.11794/10646310.1016/j.chemosphere.2022.136797 |
container_title |
Chemosphere |
container_volume |
310 |
container_start_page |
136797 |
_version_ |
1802640860983066624 |