Repositioning of the global epicentre of non-optimal cholesterol.
High blood cholesterol is typically considered a feature of wealthy western countries 1,2 . However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world 3 and countries are using lipid-lowering medications at varying rates. These changes can have disti...
Published in: | Nature |
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Format: | Article in Journal/Newspaper |
Language: | English |
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2020
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Online Access: | https://serval.unil.ch/notice/serval:BIB_8CEFDB3A3F0B https://doi.org/10.1038/s41586-020-2338-1 https://serval.unil.ch/resource/serval:BIB_8CEFDB3A3F0B.P001/REF.pdf |
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Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
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topic |
Adolescent Adult Aged 80 and over Bayes Theorem Cholesterol HDL/blood LDL/blood Female Humans Hypercholesterolemia/blood Hypercholesterolemia/epidemiology Internationality Male Middle Aged Myocardial Ischemia/blood Myocardial Ischemia/epidemiology Stroke/blood Stroke/epidemiology Triglycerides/blood Young Adult |
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Adolescent Adult Aged 80 and over Bayes Theorem Cholesterol HDL/blood LDL/blood Female Humans Hypercholesterolemia/blood Hypercholesterolemia/epidemiology Internationality Male Middle Aged Myocardial Ischemia/blood Myocardial Ischemia/epidemiology Stroke/blood Stroke/epidemiology Triglycerides/blood Young Adult Taddei, C. Repositioning of the global epicentre of non-optimal cholesterol. |
topic_facet |
Adolescent Adult Aged 80 and over Bayes Theorem Cholesterol HDL/blood LDL/blood Female Humans Hypercholesterolemia/blood Hypercholesterolemia/epidemiology Internationality Male Middle Aged Myocardial Ischemia/blood Myocardial Ischemia/epidemiology Stroke/blood Stroke/epidemiology Triglycerides/blood Young Adult |
description |
High blood cholesterol is typically considered a feature of wealthy western countries 1,2 . However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world 3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health 4,5 . However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment ... |
author2 |
NCD Risk Factor Collaboration (NCD-Risk) Zhou, B. Bixby, H. Carrillo-Larco, R.M. Danaei, G. Jackson, R.T. Farzadfar, F. Sophiea, M.K. Di Cesare, M. Iurilli, MLC Martinez, A.R. Asghari, G. Dhana, K. Gulayin, P. Kakarmath, S. Santero, M. Voortman, T. Riley, L.M. Cowan, M.J. Savin, S. Bennett, J.E. Stevens, G.A. Paciorek, C.J. Aekplakorn, W. Cifkova, R. Giampaoli, S. Kengne, A.P. Khang, Y.H. Kuulasmaa, K. Laxmaiah, A. Margozzini, P. Mathur, P. Nordestgaard, B.G. Zhao, D. Aadahl, M. Abarca-Gómez, L. Rahim, H.A. Abu-Rmeileh, N.M. Acosta-Cazares, B. Adams, R.J. Agdeppa, I.A. Aghazadeh-Attari, J. Aguilar-Salinas, C.A. Agyemang, C. Ahluwalia, T.S. Ahmad, N.A. Ahmadi, A. Ahmadi, N. Ahmed, S.H. Ahrens, W. |
format |
Article in Journal/Newspaper |
author |
Taddei, C. |
author_facet |
Taddei, C. |
author_sort |
Taddei, C. |
title |
Repositioning of the global epicentre of non-optimal cholesterol. |
title_short |
Repositioning of the global epicentre of non-optimal cholesterol. |
title_full |
Repositioning of the global epicentre of non-optimal cholesterol. |
title_fullStr |
Repositioning of the global epicentre of non-optimal cholesterol. |
title_full_unstemmed |
Repositioning of the global epicentre of non-optimal cholesterol. |
title_sort |
repositioning of the global epicentre of non-optimal cholesterol. |
publishDate |
2020 |
url |
https://serval.unil.ch/notice/serval:BIB_8CEFDB3A3F0B https://doi.org/10.1038/s41586-020-2338-1 https://serval.unil.ch/resource/serval:BIB_8CEFDB3A3F0B.P001/REF.pdf |
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Greenland Norway Pacific |
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Greenland Norway Pacific |
genre |
Greenland Iceland |
genre_facet |
Greenland Iceland |
op_source |
Nature, vol. 582, no. 7810, pp. 73-77 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41586-020-2338-1 info:eu-repo/semantics/altIdentifier/pmid/32494083 info:eu-repo/semantics/altIdentifier/eissn/1476-4687 https://serval.unil.ch/notice/serval:BIB_8CEFDB3A3F0B doi:10.1038/s41586-020-2338-1 urn:issn:0028-0836 https://serval.unil.ch/resource/serval:BIB_8CEFDB3A3F0B.P001/REF.pdf |
op_rights |
info:eu-repo/semantics/restrictedAccess Restricted: indefinite embargo CC BY 4.0 https://creativecommons.org/licenses/by/4.0/ |
op_doi |
https://doi.org/10.1038/s41586-020-2338-1 |
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Nature |
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582 |
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7810 |
container_start_page |
73 |
op_container_end_page |
77 |
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spelling |
ftunivlausanne:oai:serval.unil.ch:BIB_8CEFDB3A3F0B 2024-02-11T10:04:29+01:00 Repositioning of the global epicentre of non-optimal cholesterol. Taddei, C. NCD Risk Factor Collaboration (NCD-Risk) Zhou, B. Bixby, H. Carrillo-Larco, R.M. Danaei, G. Jackson, R.T. Farzadfar, F. Sophiea, M.K. Di Cesare, M. Iurilli, MLC Martinez, A.R. Asghari, G. Dhana, K. Gulayin, P. Kakarmath, S. Santero, M. Voortman, T. Riley, L.M. Cowan, M.J. Savin, S. Bennett, J.E. Stevens, G.A. Paciorek, C.J. Aekplakorn, W. Cifkova, R. Giampaoli, S. Kengne, A.P. Khang, Y.H. Kuulasmaa, K. Laxmaiah, A. Margozzini, P. Mathur, P. Nordestgaard, B.G. Zhao, D. Aadahl, M. Abarca-Gómez, L. Rahim, H.A. Abu-Rmeileh, N.M. Acosta-Cazares, B. Adams, R.J. Agdeppa, I.A. Aghazadeh-Attari, J. Aguilar-Salinas, C.A. Agyemang, C. Ahluwalia, T.S. Ahmad, N.A. Ahmadi, A. Ahmadi, N. Ahmed, S.H. Ahrens, W. 2020-06 application/pdf https://serval.unil.ch/notice/serval:BIB_8CEFDB3A3F0B https://doi.org/10.1038/s41586-020-2338-1 https://serval.unil.ch/resource/serval:BIB_8CEFDB3A3F0B.P001/REF.pdf eng eng info:eu-repo/semantics/altIdentifier/doi/10.1038/s41586-020-2338-1 info:eu-repo/semantics/altIdentifier/pmid/32494083 info:eu-repo/semantics/altIdentifier/eissn/1476-4687 https://serval.unil.ch/notice/serval:BIB_8CEFDB3A3F0B doi:10.1038/s41586-020-2338-1 urn:issn:0028-0836 https://serval.unil.ch/resource/serval:BIB_8CEFDB3A3F0B.P001/REF.pdf info:eu-repo/semantics/restrictedAccess Restricted: indefinite embargo CC BY 4.0 https://creativecommons.org/licenses/by/4.0/ Nature, vol. 582, no. 7810, pp. 73-77 Adolescent Adult Aged 80 and over Bayes Theorem Cholesterol HDL/blood LDL/blood Female Humans Hypercholesterolemia/blood Hypercholesterolemia/epidemiology Internationality Male Middle Aged Myocardial Ischemia/blood Myocardial Ischemia/epidemiology Stroke/blood Stroke/epidemiology Triglycerides/blood Young Adult info:eu-repo/semantics/article article info:eu-repo/semantics/submittedVersion 2020 ftunivlausanne https://doi.org/10.1038/s41586-020-2338-1 2024-01-22T01:04:12Z High blood cholesterol is typically considered a feature of wealthy western countries 1,2 . However, dietary and behavioural determinants of blood cholesterol are changing rapidly throughout the world 3 and countries are using lipid-lowering medications at varying rates. These changes can have distinct effects on the levels of high-density lipoprotein (HDL) cholesterol and non-HDL cholesterol, which have different effects on human health 4,5 . However, the trends of HDL and non-HDL cholesterol levels over time have not been previously reported in a global analysis. Here we pooled 1,127 population-based studies that measured blood lipids in 102.6 million individuals aged 18 years and older to estimate trends from 1980 to 2018 in mean total, non-HDL and HDL cholesterol levels for 200 countries. Globally, there was little change in total or non-HDL cholesterol from 1980 to 2018. This was a net effect of increases in low- and middle-income countries, especially in east and southeast Asia, and decreases in high-income western countries, especially those in northwestern Europe, and in central and eastern Europe. As a result, countries with the highest level of non-HDL cholesterol-which is a marker of cardiovascular risk-changed from those in western Europe such as Belgium, Finland, Greenland, Iceland, Norway, Sweden, Switzerland and Malta in 1980 to those in Asia and the Pacific, such as Tokelau, Malaysia, The Philippines and Thailand. In 2017, high non-HDL cholesterol was responsible for an estimated 3.9 million (95% credible interval 3.7 million-4.2 million) worldwide deaths, half of which occurred in east, southeast and south Asia. The global repositioning of lipid-related risk, with non-optimal cholesterol shifting from a distinct feature of high-income countries in northwestern Europe, north America and Australasia to one that affects countries in east and southeast Asia and Oceania should motivate the use of population-based policies and personal interventions to improve nutrition and enhance access to treatment ... Article in Journal/Newspaper Greenland Iceland Université de Lausanne (UNIL): Serval - Serveur académique lausannois Greenland Norway Pacific Nature 582 7810 73 77 |