Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer.
Full-term pregnancies are associated with long-term reductions in maternal risk of breast cancer, but the biological determinants of the protection are unknown. Experimental observations suggest that human chorionic gonadotropin (hCG), a major hormone of pregnancy, could play a role in this associat...
Published in: | Cancer Research |
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2010
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Online Access: | https://serval.unil.ch/notice/serval:BIB_890EB343C5BB https://doi.org/10.1158/0008-5472.CAN-09-4622 https://serval.unil.ch/resource/serval:BIB_890EB343C5BB.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_890EB343C5BB6 |
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ftunivlausanne:oai:serval.unil.ch:BIB_890EB343C5BB 2024-02-11T10:07:11+01:00 Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer. Toniolo, Paolo Grankvist, Kjell Wulff, Marianne Chen, Tianhui Johansson, Robert Schock, Helena Lenner, Per Hallmans, Göran Lehtinen, Matti Kaaks, Rudolf Wadell, Göran Zeleniuch-Jacquotte, Anne Lundin, Eva Lukanova, Annekatrin 2010 application/pdf https://serval.unil.ch/notice/serval:BIB_890EB343C5BB https://doi.org/10.1158/0008-5472.CAN-09-4622 https://serval.unil.ch/resource/serval:BIB_890EB343C5BB.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_890EB343C5BB6 eng eng info:eu-repo/semantics/altIdentifier/doi/10.1158/0008-5472.CAN-09-4622 info:eu-repo/semantics/altIdentifier/pmid/20713523 info:eu-repo/semantics/altIdentifier/pissn/1538-7445[electronic], 0008-5472[linking] info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_890EB343C5BB6 https://serval.unil.ch/notice/serval:BIB_890EB343C5BB doi:10.1158/0008-5472.CAN-09-4622 https://serval.unil.ch/resource/serval:BIB_890EB343C5BB.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_890EB343C5BB6 info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer Cancer Research, vol. 70, no. 17, pp. 6779-6786 Adolescent Adult Age Factors Breast Neoplasms/blood Breast Neoplasms/prevention & control Case-Control Studies Chorionic Gonadotropin/blood Cohort Studies Female Humans Middle Aged Pregnancy Young Adult info:eu-repo/semantics/article article info:eu-repo/semantics/submittedVersion 2010 ftunivlausanne https://doi.org/10.1158/0008-5472.CAN-09-4622 2024-01-22T01:04:29Z Full-term pregnancies are associated with long-term reductions in maternal risk of breast cancer, but the biological determinants of the protection are unknown. Experimental observations suggest that human chorionic gonadotropin (hCG), a major hormone of pregnancy, could play a role in this association. A case-control study (242 cases and 450 controls) nested within the Northern Sweden Maternity Cohort included women who had donated a blood sample during the first trimester of a first full-term pregnancy. Total hCG was determined on Immulite 2000 analyzer. Odds ratios (OR) and 95% confidence intervals (CI) were estimated through conditional logistic regression. Maternal breast cancer risk decreased with increasing hCG (upper tertile OR, 0.67; CI, 0.46-0.99), especially for pregnancies before age 25 (upper tertile OR, 0.41; CI, 0.21-0.80). The association diverged according to age at diagnosis: risk was reduced after age 40 (upper tertile OR, 0.60; CI, 0.39-0.91) and seemed to increase before age 40 (upper tertile OR, 1.78; CI, 0.72-4.38). Risk was reduced among those diagnosed 10 years or longer after blood draw (upper tertile OR, 0.60; CI, 0.40-0.90), but not so among those diagnosed within 10 years (upper tertile OR, 4.33; CI, 0.86-21.7). These observations suggest that the association between pregnancy hCG and subsequent maternal risk of breast cancer is modified by age at diagnosis. Although the hormone seems to be a determinant of the reduced risk around or after age 50, it might not confer protection against, or it could even increase the risk of, cancers diagnosed in the years immediately following pregnancy. Article in Journal/Newspaper Northern Sweden Université de Lausanne (UNIL): Serval - Serveur académique lausannois Cancer Research 70 17 6779 6786 |
institution |
Open Polar |
collection |
Université de Lausanne (UNIL): Serval - Serveur académique lausannois |
op_collection_id |
ftunivlausanne |
language |
English |
topic |
Adolescent Adult Age Factors Breast Neoplasms/blood Breast Neoplasms/prevention & control Case-Control Studies Chorionic Gonadotropin/blood Cohort Studies Female Humans Middle Aged Pregnancy Young Adult |
spellingShingle |
Adolescent Adult Age Factors Breast Neoplasms/blood Breast Neoplasms/prevention & control Case-Control Studies Chorionic Gonadotropin/blood Cohort Studies Female Humans Middle Aged Pregnancy Young Adult Toniolo, Paolo Grankvist, Kjell Wulff, Marianne Chen, Tianhui Johansson, Robert Schock, Helena Lenner, Per Hallmans, Göran Lehtinen, Matti Kaaks, Rudolf Wadell, Göran Zeleniuch-Jacquotte, Anne Lundin, Eva Lukanova, Annekatrin Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer. |
topic_facet |
Adolescent Adult Age Factors Breast Neoplasms/blood Breast Neoplasms/prevention & control Case-Control Studies Chorionic Gonadotropin/blood Cohort Studies Female Humans Middle Aged Pregnancy Young Adult |
description |
Full-term pregnancies are associated with long-term reductions in maternal risk of breast cancer, but the biological determinants of the protection are unknown. Experimental observations suggest that human chorionic gonadotropin (hCG), a major hormone of pregnancy, could play a role in this association. A case-control study (242 cases and 450 controls) nested within the Northern Sweden Maternity Cohort included women who had donated a blood sample during the first trimester of a first full-term pregnancy. Total hCG was determined on Immulite 2000 analyzer. Odds ratios (OR) and 95% confidence intervals (CI) were estimated through conditional logistic regression. Maternal breast cancer risk decreased with increasing hCG (upper tertile OR, 0.67; CI, 0.46-0.99), especially for pregnancies before age 25 (upper tertile OR, 0.41; CI, 0.21-0.80). The association diverged according to age at diagnosis: risk was reduced after age 40 (upper tertile OR, 0.60; CI, 0.39-0.91) and seemed to increase before age 40 (upper tertile OR, 1.78; CI, 0.72-4.38). Risk was reduced among those diagnosed 10 years or longer after blood draw (upper tertile OR, 0.60; CI, 0.40-0.90), but not so among those diagnosed within 10 years (upper tertile OR, 4.33; CI, 0.86-21.7). These observations suggest that the association between pregnancy hCG and subsequent maternal risk of breast cancer is modified by age at diagnosis. Although the hormone seems to be a determinant of the reduced risk around or after age 50, it might not confer protection against, or it could even increase the risk of, cancers diagnosed in the years immediately following pregnancy. |
format |
Article in Journal/Newspaper |
author |
Toniolo, Paolo Grankvist, Kjell Wulff, Marianne Chen, Tianhui Johansson, Robert Schock, Helena Lenner, Per Hallmans, Göran Lehtinen, Matti Kaaks, Rudolf Wadell, Göran Zeleniuch-Jacquotte, Anne Lundin, Eva Lukanova, Annekatrin |
author_facet |
Toniolo, Paolo Grankvist, Kjell Wulff, Marianne Chen, Tianhui Johansson, Robert Schock, Helena Lenner, Per Hallmans, Göran Lehtinen, Matti Kaaks, Rudolf Wadell, Göran Zeleniuch-Jacquotte, Anne Lundin, Eva Lukanova, Annekatrin |
author_sort |
Toniolo, Paolo |
title |
Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer. |
title_short |
Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer. |
title_full |
Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer. |
title_fullStr |
Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer. |
title_full_unstemmed |
Human chorionic gonadotropin in pregnancy and maternal risk of breast cancer. |
title_sort |
human chorionic gonadotropin in pregnancy and maternal risk of breast cancer. |
publishDate |
2010 |
url |
https://serval.unil.ch/notice/serval:BIB_890EB343C5BB https://doi.org/10.1158/0008-5472.CAN-09-4622 https://serval.unil.ch/resource/serval:BIB_890EB343C5BB.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_890EB343C5BB6 |
genre |
Northern Sweden |
genre_facet |
Northern Sweden |
op_source |
Cancer Research, vol. 70, no. 17, pp. 6779-6786 |
op_relation |
info:eu-repo/semantics/altIdentifier/doi/10.1158/0008-5472.CAN-09-4622 info:eu-repo/semantics/altIdentifier/pmid/20713523 info:eu-repo/semantics/altIdentifier/pissn/1538-7445[electronic], 0008-5472[linking] info:eu-repo/semantics/altIdentifier/urn/urn:nbn:ch:serval-BIB_890EB343C5BB6 https://serval.unil.ch/notice/serval:BIB_890EB343C5BB doi:10.1158/0008-5472.CAN-09-4622 https://serval.unil.ch/resource/serval:BIB_890EB343C5BB.P001/REF.pdf http://nbn-resolving.org/urn/resolver.pl?urn=urn:nbn:ch:serval-BIB_890EB343C5BB6 |
op_rights |
info:eu-repo/semantics/openAccess Copying allowed only for non-profit organizations https://serval.unil.ch/disclaimer |
op_doi |
https://doi.org/10.1158/0008-5472.CAN-09-4622 |
container_title |
Cancer Research |
container_volume |
70 |
container_issue |
17 |
container_start_page |
6779 |
op_container_end_page |
6786 |
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1790605345505148928 |