Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter
During evolution, mitochondrial DNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating n...
Published in: | Scandinavian Journal of Medicine & Science in Sports |
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Language: | English |
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Online Access: | http://hdl.handle.net/10553/50924 https://doi.org/10.1111/sms.12612 |
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ftunivlaspalmas:oai:https://accedacris.ulpgc.es:10553/50924 2023-05-15T14:55:04+02:00 Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter Gnaiger, E. Boushel, R. Søndergaard, H. Munch-Andersen, T. Damsgaard, R. Hagen, C. Díez-Sánchez, C. Ara, I. Wright-Paradis, C. Schrauwen, P. Hesselink, M. Calbet, J. A. L. Christiansen, M. Helge, J. W. Saltin, B. Calbet, Jose A Helge, Jorn Ara Royo, Ignacio schrauwen, patrick Gnaiger, Erich 55365839300 7003471688 36958968500 20735070800 6506963877 55645082100 6506330419 57201415994 36740604300 7003942896 7004164830 7004323423 7102525297 20334409300 7103099936 156181 220476 1592176 3384687 1055810 234106 1978686 238859 7863187 66440 102527 90295 16539595 147585 13919 2015 http://hdl.handle.net/10553/50924 https://doi.org/10.1111/sms.12612 eng eng 0905-7188 Scandinavian Journal of Medicine and Science in Sports 0905-7188 http://hdl.handle.net/10553/50924 doi:10.1111/sms.12612 WOS:000365322300023 84948402625 000365322300023 134 126 25 WOS:000365322300023 H-6693-2015 I-7096-2012 No ID No ID No ID Scandinavian Journal Of Medicine & Science In Sports[ISSN 0905-7188],v. 25, p. 126-134 241106 Fisiología del ejercicio 2015 ftunivlaspalmas https://doi.org/10.1111/sms.12612 2019-09-08T16:51:50Z During evolution, mitochondrial DNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fiber type, and uncoupling protein‐3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from VO2max and maximum capacities of oxidative phosphorylation. Other/Unknown Material Arctic Greenland inuit Universidad de Las Palmas de Gran Canaria: Acceda Arctic Greenland Scandinavian Journal of Medicine & Science in Sports 25 126 134 |
institution |
Open Polar |
collection |
Universidad de Las Palmas de Gran Canaria: Acceda |
op_collection_id |
ftunivlaspalmas |
language |
English |
topic |
241106 Fisiología del ejercicio |
spellingShingle |
241106 Fisiología del ejercicio Gnaiger, E. Boushel, R. Søndergaard, H. Munch-Andersen, T. Damsgaard, R. Hagen, C. Díez-Sánchez, C. Ara, I. Wright-Paradis, C. Schrauwen, P. Hesselink, M. Calbet, J. A. L. Christiansen, M. Helge, J. W. Saltin, B. Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter |
topic_facet |
241106 Fisiología del ejercicio |
description |
During evolution, mitochondrial DNA haplogroups of arctic populations may have been selected for lower coupling of mitochondrial respiration to ATP production in favor of higher heat production. We show that mitochondrial coupling in skeletal muscle of traditional and westernized Inuit habituating northern Greenland is identical to Danes of western Europe haplogroups. Biochemical coupling efficiency was preserved across variations in diet, muscle fiber type, and uncoupling protein‐3 content. Mitochondrial phenotype displayed plasticity in relation to lifestyle and environment. Untrained Inuit and Danes had identical capacities to oxidize fat substrate in arm muscle, which increased in Danes during the 42 days of acclimation to exercise, approaching the higher level of the Inuit hunters. A common pattern emerges of mitochondrial acclimatization and evolutionary adaptation in humans at high latitude and high altitude where economy of locomotion may be optimized by preservation of biochemical coupling efficiency at modest mitochondrial density, when submaximum performance is uncoupled from VO2max and maximum capacities of oxidative phosphorylation. |
author2 |
Calbet, Jose A Helge, Jorn Ara Royo, Ignacio schrauwen, patrick Gnaiger, Erich 55365839300 7003471688 36958968500 20735070800 6506963877 55645082100 6506330419 57201415994 36740604300 7003942896 7004164830 7004323423 7102525297 20334409300 7103099936 156181 220476 1592176 3384687 1055810 234106 1978686 238859 7863187 66440 102527 90295 16539595 147585 13919 |
author |
Gnaiger, E. Boushel, R. Søndergaard, H. Munch-Andersen, T. Damsgaard, R. Hagen, C. Díez-Sánchez, C. Ara, I. Wright-Paradis, C. Schrauwen, P. Hesselink, M. Calbet, J. A. L. Christiansen, M. Helge, J. W. Saltin, B. |
author_facet |
Gnaiger, E. Boushel, R. Søndergaard, H. Munch-Andersen, T. Damsgaard, R. Hagen, C. Díez-Sánchez, C. Ara, I. Wright-Paradis, C. Schrauwen, P. Hesselink, M. Calbet, J. A. L. Christiansen, M. Helge, J. W. Saltin, B. |
author_sort |
Gnaiger, E. |
title |
Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter |
title_short |
Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter |
title_full |
Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter |
title_fullStr |
Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter |
title_full_unstemmed |
Mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of Inuit and Caucasians in the arctic winter |
title_sort |
mitochondrial coupling and capacity of oxidative phosphorylation in skeletal muscle of inuit and caucasians in the arctic winter |
publisher |
0905-7188 |
publishDate |
2015 |
url |
http://hdl.handle.net/10553/50924 https://doi.org/10.1111/sms.12612 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Greenland inuit |
genre_facet |
Arctic Greenland inuit |
op_source |
Scandinavian Journal Of Medicine & Science In Sports[ISSN 0905-7188],v. 25, p. 126-134 |
op_relation |
Scandinavian Journal of Medicine and Science in Sports 0905-7188 http://hdl.handle.net/10553/50924 doi:10.1111/sms.12612 WOS:000365322300023 84948402625 000365322300023 134 126 25 WOS:000365322300023 H-6693-2015 I-7096-2012 No ID No ID No ID |
op_doi |
https://doi.org/10.1111/sms.12612 |
container_title |
Scandinavian Journal of Medicine & Science in Sports |
container_volume |
25 |
container_start_page |
126 |
op_container_end_page |
134 |
_version_ |
1766326854823706624 |