Cetacean morbillivirus: Current knowledge and future directions

• Published in: Viruses
• Main Authors: Van Bressem, Marie Françoise, Duignan, Pádraig J., Banyard, Ashley C., Barbieri, Michelle M., Colegrove, Kathleen M., de Guise, Sylvain, Di Guardo, Giovanni, Dobson, Andrew D. M., Domingo Álvarez, Mariano, Fauquier, Deborah A., Fernández Rodríguez, Antonio Jesús, Goldstein, Tracey A., Grenfell, Bryan T., Groch, Kátia Regina, Gulland, Frances M. D., Jensen, Brenda A., Jepson, Paul D., Hall, Ailsa J., Kuiken, Thijs, Mazzariol, Sandro, Morris, Sinead E., Nielsen, Ole, Raga Esteve, Juan Antonio, Rowles, Teresa K., Saliki, Jeremiah T., Sierra Pulpillo, Eva María, Stephens, Nahiid, Stone, Brett M., Tomo, Ikuko, Wang, Jianning, Waltzek, Thomas B., Wellehan, James Fx X.
• Other Authors: Fernandez, Antonio, Banyard, Ashley, Sierra, Eva, APHA, Staff publications, Raga, Juan Antonio, Hall, Ailsa, #NODATA#, 7003659694, 7003529114, 9035976700, 55814173100, 9243993900, 7004208103, 36860870100, 7202943634, 37080570100, 7005595725, 6506861996, 56673009900, 7004660880, 7004421686, 37072358500, 7006272482, 57203051034, 7006738308, 35798139800, 26643529400, 24173815500, 56460750900, 7202851915, 7004329765, 6603419429, 35517361900, 15742962600, 55694517300, 54905117700, 6602978261, 56074122800, 6507324896, 6603743908, 1490240, 303423, 499148, 3332261, 841494, 393890, 364862, 64085, 34967
• Format: Article in Journal/Newspaper
• Language: English
• Published: 2014
• Subjects: 242091 Virología animal; 310911 Virología; 240118 Mamíferos; Bottle-Nosed Dolphins; Canine-Distemper-Virus; Porpoises Phocoena-Phocoena; Polymerase-Chain-Reaction; Measles-Virus; Striped Dolphins; Stenella-Coeruleoalba; Tursiops-Truncatus; Epithelial Receptor; Postmortem Findings; Cetacean morbillivirus; Epidemics; Mass stranding; SLAM; Signaling Lymphocyte Activation Molecule; Phylogeny; Pathogenesis; Diagnosis; Endemic infections; Phocoena phocoena
• Online Access: http://hdl.handle.net/10553/47509; https://doi.org/10.3390/v6125145

We review the molecular and epidemiological characteristics of cetacean morbillivirus (CeMV) and the diagnosis and pathogenesis of associated disease, with six different strains detected in cetaceans worldwide. CeMV has caused epidemics with high mortality in odontocetes in Europe, the USA and Australia. It represents a distinct species within the Morbillivirus genus. Although most CeMV strains are phylogenetically closely related, recent data indicate that morbilliviruses recovered from Indo-Pacific bottlenose dolphins (Tursiops aduncus), from Western Australia, and a Guiana dolphin (Sotalia guianensis), from Brazil, are divergent. The signaling lymphocyte activation molecule (SLAM) cell receptor for CeMV has been characterized in cetaceans. It shares higher amino acid identity with the ruminant SLAM than with the receptors of carnivores or humans, reflecting the evolutionary history of these mammalian taxa. In Delphinidae, three amino acid substitutions may result in a higher affinity for the virus. Infection is diagnosed by histology, immunohistochemistry, virus isolation, RT-PCR, and serology. Classical CeMV-associated lesions include bronchointerstitial pneumonia, encephalitis, syncytia, and lymphoid depletion associated with immunosuppression. Cetaceans that survive the acute disease may develop fatal secondary infections and chronic encephalitis. Endemically infected, gregarious odontocetes probably serve as reservoirs and vectors. Transmission likely occurs through the inhalation of aerosolized virus but mother to fetus transmission was also reported. 5181 5145 1,904 3,353 Q1 Q2 SCIE