Immunopathological study of parasitic cholangitis in cetaceans

This paper describes the immunophenotype of cellular inflammatory infiltrates in chronic cholangitis in six common dolphins (Delphinus delphis), four striped dolphins (Stenella coeruleoalba), three Atlantic spotted dolphins (Stenella frontalis) and one pygmy sperm whale (Kogia Breviceps) found stran...

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Bibliographic Details
Published in:Research in Veterinary Science
Main Authors: Jaber, J. R., Zafra, R., González Pérez, Jorge Francisco, Suárez-Bonnet, A., González, J. F., Carrascosa, C., Andrada, M., Arbelo, M., Fernández, A.
Other Authors: Perez, Jose, Arbelo, Manuel, Zafra Leva, Rafael, Fernandez, Antonio, Carrascosa, Conrado, 7004667021, 23029634000, 55597088351, 55597088346, 25636181300, 7404492965, 55243552300, 6602991535, 6603561403, 56673009900, 959492, 770447, 319037, 1256449, 1988579, 1652652, 862879, 667707, 273789, 176520, WOS:Jaber, JR, WOS:Zafra, R, WOS:Perez, J, WOS:Suarez-Bonnet, A, WOS:Gonzalez, JF, WOS:Carrascosa, C, WOS:Andrada, M, WOS:Arbelo, M, WOS:Fernandez, A
Format: Article in Journal/Newspaper
Language:Spanish
Published: 0034-5288 2013
Subjects:
Hepatic Lymph-Nodes
Monoclonal-Antibodies
Fasciola-Hepatica
Phocoena-Phocoena
Blood-Lymphocytes
Peripheral-Blood
Cross-Reactivity
Dolphin
Cells
Schistosomiasis
Phocoena phocoena
Sperm whale
Online Access:http://hdl.handle.net/10553/44139
https://doi.org/10.1016/j.rvsc.2013.05.011
Description
Summary:This paper describes the immunophenotype of cellular inflammatory infiltrates in chronic cholangitis in six common dolphins (Delphinus delphis), four striped dolphins (Stenella coeruleoalba), three Atlantic spotted dolphins (Stenella frontalis) and one pygmy sperm whale (Kogia Breviceps) found stranded along the coasts of the Canary Islands (Spain). A panel of 5 antibodies previously tested in dolphins (anti-CD3, -IgG, -MHC class II, -S100 protein and -lysozyme) were used. The present work also reports cross reactivity with dolphin antigens of two antibodies not used to date in dolphins (anti-mouse iNOS and anti-mouse Foxp3). The most common type of cholangitis found was chronic granulomatous cholangitis, associated with the presence of the parasite Campula spp., or its eggs in bile ducts. The cellular composition of the hepatic inflammatory infiltrate associated to chronic parasitic cholangitis was closely similar to that found in the cortex of control lymph nodes, including the presence of S100(+) and MHC class II+ dendritic-like cells in lymphoid follicles and interfollicular areas. Only occasional macrophages expressed iNOS, whereas Foxp3(+) lymphocytes were not found in any of the lesions described in the different types of cholangitis. (c) 2013 Elsevier Ltd. All rights reserved. 561 556 0,676 1,511 Q1 Q1 SCIE

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