In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves
Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used...
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ftunivlaplata:oai:sedici.unlp.edu.ar:10915/167379 2024-09-15T17:47:38+00:00 In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves Hugo, Ayelén Amelia Serradell, María de los Ángeles Peri, Pablo Farina, Sebastián Gómez-Zavaglia, Andrea 2024 application/pdf http://sedici.unlp.edu.ar/handle/10915/167379 en eng http://sedici.unlp.edu.ar/handle/10915/167379 http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) Química Biología Animal model antioxidant activity ñire Nothofagus antarctica toxicity Articulo 2024 ftunivlaplata 2024-06-26T00:01:50Z Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the antioxidant activity in biological samples. Toxicity tests revealed no death or signs of toxicity. No significant differences in biochemical parameters/histological structure were registered. NA infusion exhibited a high content of polyphenols and flavonoids, contributing to its remarkably antioxidant activity. The periodic administration of NA infusion could increase the antioxidant capacity in mice at intestinal level. The results support the safe of consuming NA leaves infusion and suggest their contribution for modulating the intestinal oxidative stress. Facultad de Ciencias Exactas Centro de Investigación y Desarrollo en Criotecnología de Alimentos Article in Journal/Newspaper Antarc* Antarctica Universidad Nacional de La Plata (UNLP): SeDiCI (Servicio de Difusión de la Creación Intelectual) |
institution |
Open Polar |
collection |
Universidad Nacional de La Plata (UNLP): SeDiCI (Servicio de Difusión de la Creación Intelectual) |
op_collection_id |
ftunivlaplata |
language |
English |
topic |
Química Biología Animal model antioxidant activity ñire Nothofagus antarctica toxicity |
spellingShingle |
Química Biología Animal model antioxidant activity ñire Nothofagus antarctica toxicity Hugo, Ayelén Amelia Serradell, María de los Ángeles Peri, Pablo Farina, Sebastián Gómez-Zavaglia, Andrea In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
topic_facet |
Química Biología Animal model antioxidant activity ñire Nothofagus antarctica toxicity |
description |
Nothofagus antarctica (NA) is a native tree of Patagonia. Since ancient times, NA leaves were used in infusions for medical and food purposes, but there are no deep insights on its toxicity. The aim of this work was to assess the safety and antioxidant activity of NA leaves infusion. Mice were used to determine acute and subacute oral toxicity. Total polyphenols, flavonoids and the antioxidant activity of the infusion were assessed, as well as the antioxidant activity in biological samples. Toxicity tests revealed no death or signs of toxicity. No significant differences in biochemical parameters/histological structure were registered. NA infusion exhibited a high content of polyphenols and flavonoids, contributing to its remarkably antioxidant activity. The periodic administration of NA infusion could increase the antioxidant capacity in mice at intestinal level. The results support the safe of consuming NA leaves infusion and suggest their contribution for modulating the intestinal oxidative stress. Facultad de Ciencias Exactas Centro de Investigación y Desarrollo en Criotecnología de Alimentos |
format |
Article in Journal/Newspaper |
author |
Hugo, Ayelén Amelia Serradell, María de los Ángeles Peri, Pablo Farina, Sebastián Gómez-Zavaglia, Andrea |
author_facet |
Hugo, Ayelén Amelia Serradell, María de los Ángeles Peri, Pablo Farina, Sebastián Gómez-Zavaglia, Andrea |
author_sort |
Hugo, Ayelén Amelia |
title |
In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
title_short |
In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
title_full |
In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
title_fullStr |
In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
title_full_unstemmed |
In vivo oral toxicity and antioxidant capacity of Nothofagus antarctica (G.Forst.) oerst (ñire) leaves |
title_sort |
in vivo oral toxicity and antioxidant capacity of nothofagus antarctica (g.forst.) oerst (ñire) leaves |
publishDate |
2024 |
url |
http://sedici.unlp.edu.ar/handle/10915/167379 |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
http://sedici.unlp.edu.ar/handle/10915/167379 |
op_rights |
http://creativecommons.org/licenses/by/4.0/ Creative Commons Attribution 4.0 International (CC BY 4.0) |
_version_ |
1810497097588277248 |