PCB-associated alteration of hepatic steroid metabolism in harbor seals ('Phoca vitulina')
Hepatic cytochrome P-450 (CYP450) isozymes are involved in xenobiotic detoxification and steroid metabolism. Seals are highly exposed to polychlorinated biphenyls (PCBs) in the environment, resulting in CYP450 induction, which may have concomitant effects on CYP450 steroid metabolism. Experiments we...
Published in: | Journal of Toxicology and Environmental Health, Part A |
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Taylor & Francis
2000
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Online Access: | https://eprints.kingston.ac.uk/id/eprint/7233/ https://doi.org/10.1080/00984100050195134 |
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ftunivkingston:oai:eprints.kingston.ac.uk:7233 2023-05-15T16:33:07+02:00 PCB-associated alteration of hepatic steroid metabolism in harbor seals ('Phoca vitulina') Troisi, G. M. Mason, C. F. 2000-12 https://eprints.kingston.ac.uk/id/eprint/7233/ https://doi.org/10.1080/00984100050195134 unknown Taylor & Francis Troisi, G. M. and Mason, C. F. (2000) PCB-associated alteration of hepatic steroid metabolism in harbor seals ('Phoca vitulina'). Journal of Toxicology and Environmental Health - Part A Current Issues, 61(8), pp. 649-655. ISSN (print) 1528-7394 Chemistry Biological sciences enzyme-activities ringed seals cytochrome-p-450 microsomes exposure mink rat Article PeerReviewed 2000 ftunivkingston https://doi.org/10.1080/00984100050195134 2022-02-22T09:09:26Z Hepatic cytochrome P-450 (CYP450) isozymes are involved in xenobiotic detoxification and steroid metabolism. Seals are highly exposed to polychlorinated biphenyls (PCBs) in the environment, resulting in CYP450 induction, which may have concomitant effects on CYP450 steroid metabolism. Experiments were conducted to determine rates of steroid metabolism in harbor seal (Phoca vitulina) liver. CYP450 was induced with increasing liver PCB concentrations between 0.2 and 5.73 microg/g (wet weight). Progesterone metabolism was significantly decreased with increasing liver PCB concentration. Testosterone metabolism was also increased with increasing liver PCB concentration. The results indicate a change in steroid metabolism associated with increasing PCB burden, suggesting that PCBs may have a modulating effect on hepatic steroid biotransformation in environmentally exposed seals. The possible implications of this for endocrine homeostasis in seals are discussed. Article in Journal/Newspaper harbor seal Phoca vitulina Kingston University London: Research Repository Journal of Toxicology and Environmental Health, Part A 61 8 649 655 |
institution |
Open Polar |
collection |
Kingston University London: Research Repository |
op_collection_id |
ftunivkingston |
language |
unknown |
topic |
Chemistry Biological sciences enzyme-activities ringed seals cytochrome-p-450 microsomes exposure mink rat |
spellingShingle |
Chemistry Biological sciences enzyme-activities ringed seals cytochrome-p-450 microsomes exposure mink rat Troisi, G. M. Mason, C. F. PCB-associated alteration of hepatic steroid metabolism in harbor seals ('Phoca vitulina') |
topic_facet |
Chemistry Biological sciences enzyme-activities ringed seals cytochrome-p-450 microsomes exposure mink rat |
description |
Hepatic cytochrome P-450 (CYP450) isozymes are involved in xenobiotic detoxification and steroid metabolism. Seals are highly exposed to polychlorinated biphenyls (PCBs) in the environment, resulting in CYP450 induction, which may have concomitant effects on CYP450 steroid metabolism. Experiments were conducted to determine rates of steroid metabolism in harbor seal (Phoca vitulina) liver. CYP450 was induced with increasing liver PCB concentrations between 0.2 and 5.73 microg/g (wet weight). Progesterone metabolism was significantly decreased with increasing liver PCB concentration. Testosterone metabolism was also increased with increasing liver PCB concentration. The results indicate a change in steroid metabolism associated with increasing PCB burden, suggesting that PCBs may have a modulating effect on hepatic steroid biotransformation in environmentally exposed seals. The possible implications of this for endocrine homeostasis in seals are discussed. |
format |
Article in Journal/Newspaper |
author |
Troisi, G. M. Mason, C. F. |
author_facet |
Troisi, G. M. Mason, C. F. |
author_sort |
Troisi, G. M. |
title |
PCB-associated alteration of hepatic steroid metabolism in harbor seals ('Phoca vitulina') |
title_short |
PCB-associated alteration of hepatic steroid metabolism in harbor seals ('Phoca vitulina') |
title_full |
PCB-associated alteration of hepatic steroid metabolism in harbor seals ('Phoca vitulina') |
title_fullStr |
PCB-associated alteration of hepatic steroid metabolism in harbor seals ('Phoca vitulina') |
title_full_unstemmed |
PCB-associated alteration of hepatic steroid metabolism in harbor seals ('Phoca vitulina') |
title_sort |
pcb-associated alteration of hepatic steroid metabolism in harbor seals ('phoca vitulina') |
publisher |
Taylor & Francis |
publishDate |
2000 |
url |
https://eprints.kingston.ac.uk/id/eprint/7233/ https://doi.org/10.1080/00984100050195134 |
genre |
harbor seal Phoca vitulina |
genre_facet |
harbor seal Phoca vitulina |
op_relation |
Troisi, G. M. and Mason, C. F. (2000) PCB-associated alteration of hepatic steroid metabolism in harbor seals ('Phoca vitulina'). Journal of Toxicology and Environmental Health - Part A Current Issues, 61(8), pp. 649-655. ISSN (print) 1528-7394 |
op_doi |
https://doi.org/10.1080/00984100050195134 |
container_title |
Journal of Toxicology and Environmental Health, Part A |
container_volume |
61 |
container_issue |
8 |
container_start_page |
649 |
op_container_end_page |
655 |
_version_ |
1766022830920564736 |