Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims
Polychlorinated biphenyl (PCB) and dichlorodiphenylethane (DDE) methyl sulfone (MSF) metabolites possess high affinities for binding two homologous 16,000 Da homodimeric receptor proteins in the lung (Clara cell secretory protein, CCSP) and the uterus (uteroglobin, UG), leading to selective bioaccum...
Published in: | Journal of Toxicology and Environmental Health, Part A |
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2000
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Online Access: | https://eprints.kingston.ac.uk/id/eprint/7230/ https://doi.org/10.1080/00984100050201622 |
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ftunivkingston:oai:eprints.kingston.ac.uk:7230 2023-05-15T16:33:09+02:00 Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims Troisi, G.M. Haraguchi, K. Kaydoo, D.S. Nyman, M. Aguilar, A. Borrell, A. Siebert, U. Mason, C.F. 2000-12 https://eprints.kingston.ac.uk/id/eprint/7230/ https://doi.org/10.1080/00984100050201622 unknown Taylor & Francis Inc. Troisi, G.M., Haraguchi, K., Kaydoo, D.S., Nyman, M., Aguilar, A., Borrell, A., Siebert, U. and Mason, C.F. (2000) Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims. Journal of Toxicology and Environmental Health - Part A Current Issues, 62(1), pp. 1-8. ISSN (print) 1528-7394 Biological sciences target-cells contaminants uteroglobin metabolites cetaceans binding waters irish coast Article PeerReviewed 2000 ftunivkingston https://doi.org/10.1080/00984100050201622 2022-02-22T09:09:26Z Polychlorinated biphenyl (PCB) and dichlorodiphenylethane (DDE) methyl sulfone (MSF) metabolites possess high affinities for binding two homologous 16,000 Da homodimeric receptor proteins in the lung (Clara cell secretory protein, CCSP) and the uterus (uteroglobin, UG), leading to selective bioaccumulation of MSFs in these tissues. As marine mammals are highly exposed to organochlorines, concentrations of PCBs, PCB MSFs, DDT, and DDE MSF were analyzed in blubber, lung, and uterus samples from harbor seal (Phoca vitulina) and striped dolphin (Stenella coeruleoalba) morbillivirus epizootic victims to investigate uterine and lung MSF accumulation. Mean uterus concentrations of PCB MSFs and DDE MSF in harbor seals were 0.61 and 0.04 microg/g lipid weight and in striped dolphins 0.05 and 0.01 microg/g lipid weight. Mean lung concentrations of PCB MSFs and DDE MSF in harbor seals were 0.96 and 0.02 microg/g lipid weight and in striped dolphins 0.16 and 0.01 microg/g lipid weight. To ascertain whether uterine and lung bioaccumulation of MSFs is possible due to the presence of CCSP and UG in seals, CCSP and UG proteins in uterine flushings and in uterine and lung and epithelial tissue from Baltic gray and ringed seals were characterized using gel electrophoresis and Western blotting techniques. UG- and CCSP-like proteins with molecular weights of 16,000 Da were resolved in all samples. This is the first demonstration of this protein in any marine mammalian species. The toxicological implications of MSF binding with UG and CCSP in marine mammals are discussed. Article in Journal/Newspaper harbor seal Phoca vitulina Kingston University London: Research Repository Journal of Toxicology and Environmental Health, Part A 62 1 1 8 |
institution |
Open Polar |
collection |
Kingston University London: Research Repository |
op_collection_id |
ftunivkingston |
language |
unknown |
topic |
Biological sciences target-cells contaminants uteroglobin metabolites cetaceans binding waters irish coast |
spellingShingle |
Biological sciences target-cells contaminants uteroglobin metabolites cetaceans binding waters irish coast Troisi, G.M. Haraguchi, K. Kaydoo, D.S. Nyman, M. Aguilar, A. Borrell, A. Siebert, U. Mason, C.F. Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims |
topic_facet |
Biological sciences target-cells contaminants uteroglobin metabolites cetaceans binding waters irish coast |
description |
Polychlorinated biphenyl (PCB) and dichlorodiphenylethane (DDE) methyl sulfone (MSF) metabolites possess high affinities for binding two homologous 16,000 Da homodimeric receptor proteins in the lung (Clara cell secretory protein, CCSP) and the uterus (uteroglobin, UG), leading to selective bioaccumulation of MSFs in these tissues. As marine mammals are highly exposed to organochlorines, concentrations of PCBs, PCB MSFs, DDT, and DDE MSF were analyzed in blubber, lung, and uterus samples from harbor seal (Phoca vitulina) and striped dolphin (Stenella coeruleoalba) morbillivirus epizootic victims to investigate uterine and lung MSF accumulation. Mean uterus concentrations of PCB MSFs and DDE MSF in harbor seals were 0.61 and 0.04 microg/g lipid weight and in striped dolphins 0.05 and 0.01 microg/g lipid weight. Mean lung concentrations of PCB MSFs and DDE MSF in harbor seals were 0.96 and 0.02 microg/g lipid weight and in striped dolphins 0.16 and 0.01 microg/g lipid weight. To ascertain whether uterine and lung bioaccumulation of MSFs is possible due to the presence of CCSP and UG in seals, CCSP and UG proteins in uterine flushings and in uterine and lung and epithelial tissue from Baltic gray and ringed seals were characterized using gel electrophoresis and Western blotting techniques. UG- and CCSP-like proteins with molecular weights of 16,000 Da were resolved in all samples. This is the first demonstration of this protein in any marine mammalian species. The toxicological implications of MSF binding with UG and CCSP in marine mammals are discussed. |
format |
Article in Journal/Newspaper |
author |
Troisi, G.M. Haraguchi, K. Kaydoo, D.S. Nyman, M. Aguilar, A. Borrell, A. Siebert, U. Mason, C.F. |
author_facet |
Troisi, G.M. Haraguchi, K. Kaydoo, D.S. Nyman, M. Aguilar, A. Borrell, A. Siebert, U. Mason, C.F. |
author_sort |
Troisi, G.M. |
title |
Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims |
title_short |
Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims |
title_full |
Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims |
title_fullStr |
Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims |
title_full_unstemmed |
Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims |
title_sort |
bioaccumulation of polychlorinated biphenyls (pcbs) and dichlorodiphenylethane (dde) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims |
publisher |
Taylor & Francis Inc. |
publishDate |
2000 |
url |
https://eprints.kingston.ac.uk/id/eprint/7230/ https://doi.org/10.1080/00984100050201622 |
genre |
harbor seal Phoca vitulina |
genre_facet |
harbor seal Phoca vitulina |
op_relation |
Troisi, G.M., Haraguchi, K., Kaydoo, D.S., Nyman, M., Aguilar, A., Borrell, A., Siebert, U. and Mason, C.F. (2000) Bioaccumulation of polychlorinated biphenyls (PCBs) and dichlorodiphenylethane (DDE) methyl sulfones in tissues of seal and dolphin morbillivirus epizootic victims. Journal of Toxicology and Environmental Health - Part A Current Issues, 62(1), pp. 1-8. ISSN (print) 1528-7394 |
op_doi |
https://doi.org/10.1080/00984100050201622 |
container_title |
Journal of Toxicology and Environmental Health, Part A |
container_volume |
62 |
container_issue |
1 |
container_start_page |
1 |
op_container_end_page |
8 |
_version_ |
1766022869480898560 |