Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966
Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth me...
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ftunivkingston:oai:eprints.kingston.ac.uk:40223 2023-05-15T17:42:33+02:00 Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966 Buxton, Jessica L. Das, Shikta Rodriguez, Alina Kaakinen, Marika Couto Alves, Alexessander Sebert, Sylvain Millwood, Iona Y. Laitinen, Jaana O'Reilly, Paul F. Jarvelin, Marjo-Riitta Blakemore, Alexandra I. F. 2014-06-11 text https://eprints.kingston.ac.uk/id/eprint/40223/ https://eprints.kingston.ac.uk/id/eprint/40223/6/Buxton-J-40223-VoR.PDF https://doi.org/10.1371/journal.pone.0099133 en eng Public Library of Science https://eprints.kingston.ac.uk/id/eprint/40223/6/Buxton-J-40223-VoR.PDF Buxton, Jessica L., Das, Shikta, Rodriguez, Alina, Kaakinen, Marika, Couto Alves, Alexessander, Sebert, Sylvain, Millwood, Iona Y., Laitinen, Jaana, O'Reilly, Paul F., Jarvelin, Marjo-Riitta and Blakemore, Alexandra I. F. (2014) Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966. PLoS ONE, 9(6), e99133. ISSN (online) 1932-6203 cc_by_4 CC-BY Biological sciences Epidemiology and public health Article PeerReviewed 2014 ftunivkingston https://doi.org/10.1371/journal.pone.0099133 2022-02-22T09:39:19Z Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and iii) adult BMI, waist-to-hip ratio (WHR), body adiposity index (BAI). Childhood BMI at AR was positively associated with LTL at 31 years in women (P = 0.041). Adult BMI and WHR in both men (P = 0.025 and P = 0.049, respectively) and women (P = 0.029 and P = 0.008, respectively), and BAI in women (P = 0.021) were inversely associated with LTL at 31 years. An increase in standardised BMI between early childhood and adulthood was associated with shorter adult LTL in women (P = 0.008). We show that LTL is inversely associated with multiple measures of adiposity in both men and women. Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing. Article in Journal/Newspaper Northern Finland Kingston University London: Research Repository PLoS ONE 9 6 e99133 |
institution |
Open Polar |
collection |
Kingston University London: Research Repository |
op_collection_id |
ftunivkingston |
language |
English |
topic |
Biological sciences Epidemiology and public health |
spellingShingle |
Biological sciences Epidemiology and public health Buxton, Jessica L. Das, Shikta Rodriguez, Alina Kaakinen, Marika Couto Alves, Alexessander Sebert, Sylvain Millwood, Iona Y. Laitinen, Jaana O'Reilly, Paul F. Jarvelin, Marjo-Riitta Blakemore, Alexandra I. F. Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966 |
topic_facet |
Biological sciences Epidemiology and public health |
description |
Studies of leukocyte telomere length (LTL) and adiposity have produced conflicting results, and the relationship between body mass index (BMI) and telomere length throughout life remains unclear. We therefore tested association of adult LTL measured in 5,598 participants with: i) childhood growth measures (BMI and age at adiposity rebound (AR)); ii) change in BMI from childhood to adulthood and iii) adult BMI, waist-to-hip ratio (WHR), body adiposity index (BAI). Childhood BMI at AR was positively associated with LTL at 31 years in women (P = 0.041). Adult BMI and WHR in both men (P = 0.025 and P = 0.049, respectively) and women (P = 0.029 and P = 0.008, respectively), and BAI in women (P = 0.021) were inversely associated with LTL at 31 years. An increase in standardised BMI between early childhood and adulthood was associated with shorter adult LTL in women (P = 0.008). We show that LTL is inversely associated with multiple measures of adiposity in both men and women. Additionally, BMI increase in women from childhood to adulthood is associated with shorter telomeres at age 31, potentially indicating accelerated biological ageing. |
format |
Article in Journal/Newspaper |
author |
Buxton, Jessica L. Das, Shikta Rodriguez, Alina Kaakinen, Marika Couto Alves, Alexessander Sebert, Sylvain Millwood, Iona Y. Laitinen, Jaana O'Reilly, Paul F. Jarvelin, Marjo-Riitta Blakemore, Alexandra I. F. |
author_facet |
Buxton, Jessica L. Das, Shikta Rodriguez, Alina Kaakinen, Marika Couto Alves, Alexessander Sebert, Sylvain Millwood, Iona Y. Laitinen, Jaana O'Reilly, Paul F. Jarvelin, Marjo-Riitta Blakemore, Alexandra I. F. |
author_sort |
Buxton, Jessica L. |
title |
Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966 |
title_short |
Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966 |
title_full |
Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966 |
title_fullStr |
Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966 |
title_full_unstemmed |
Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966 |
title_sort |
multiple measures of adiposity are associated with mean leukocyte telomere length in the northern finland birth cohort 1966 |
publisher |
Public Library of Science |
publishDate |
2014 |
url |
https://eprints.kingston.ac.uk/id/eprint/40223/ https://eprints.kingston.ac.uk/id/eprint/40223/6/Buxton-J-40223-VoR.PDF https://doi.org/10.1371/journal.pone.0099133 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_relation |
https://eprints.kingston.ac.uk/id/eprint/40223/6/Buxton-J-40223-VoR.PDF Buxton, Jessica L., Das, Shikta, Rodriguez, Alina, Kaakinen, Marika, Couto Alves, Alexessander, Sebert, Sylvain, Millwood, Iona Y., Laitinen, Jaana, O'Reilly, Paul F., Jarvelin, Marjo-Riitta and Blakemore, Alexandra I. F. (2014) Multiple measures of adiposity are associated with mean leukocyte telomere length in the Northern Finland Birth Cohort 1966. PLoS ONE, 9(6), e99133. ISSN (online) 1932-6203 |
op_rights |
cc_by_4 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1371/journal.pone.0099133 |
container_title |
PLoS ONE |
container_volume |
9 |
container_issue |
6 |
container_start_page |
e99133 |
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1766144422214369280 |