Development and application of non-destructive biomarkers for biomonitoring endocrine disruption in pinnipeds
Over the past years there has been an increased concern regarding widespread pollution of the environment with persistent organic pollutants (POPs) that biomagnify and bioaccumulate along the food chain. Marine mammals, especially seals being top predators of the marine food chain, are significantly...
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ftunivkingston:oai:eprints.kingston.ac.uk:20378 2023-10-09T21:55:16+02:00 Development and application of non-destructive biomarkers for biomonitoring endocrine disruption in pinnipeds Liori, Ourania 2006 text https://eprints.kingston.ac.uk/id/eprint/20378/ https://eprints.kingston.ac.uk/id/eprint/20378/1/Liori-O.pdf http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433819 en eng Kingston University https://eprints.kingston.ac.uk/id/eprint/20378/1/Liori-O.pdf Liori, Ourania (2006) Development and application of non-destructive biomarkers for biomonitoring endocrine disruption in pinnipeds. (PhD thesis), Kingston University, . Biological sciences Thesis NonPeerReviewed 2006 ftunivkingston 2023-09-14T22:26:57Z Over the past years there has been an increased concern regarding widespread pollution of the environment with persistent organic pollutants (POPs) that biomagnify and bioaccumulate along the food chain. Marine mammals, especially seals being top predators of the marine food chain, are significantly exposed to biomagnified levels of POPs that bioaccumulate in the blubber which acts as a reservoir for these lipophilic compounds. POPs have been associated with a number of pathological changes in the seals, thus early detection of the adverse health effects resulting from pollutant exposure is vital, since exposure may cause irreversible damage to entire populations or ecosystems in the long term. Biomonitoring studies to investigate changes in fecundity of marine mammal populations due to exposure to POPs are needed. Biological indicators (biomarkers) that reflect the exposure levels or toxic effects of the contaminant load in wildlife populations can be used as early warning system for the reproduction and survival of the animals with non-destructive or minimal invasion. The aim of this study was to research and develop new and existing exposure and effect biomarkers for biomonitoring endocrine disruption in Ringed (Phoca hispida), Grey (Halichoerus grypus) and Harbour (Phoca vitulina) seals from different geographical areas using non-destructive/non-invasive sampling. Sex steroids, lactoferrin and blood chemistry parameters were investigated ill seal faecal and serum samples as potential biomarkers. Exposure level (PCBs, DDT, PBDEs) was determined using chromatographic and immunoassay techniques. Estrogens in the exposed populations showed a negative correlation with contaminant exposure and higher LTF, glucose and lipoprotein levels showed a positive correlation with contaminant exposure and negative correlation with sex steroids, thus they are proposed as biomarkers of endocrine disruption. This is the first study to quantify and measure LTF as well as sex steroids in seal faecal samples and to investigate ... Thesis Phoca hispida Phoca vitulina Kingston University London: Research Repository |
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Kingston University London: Research Repository |
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English |
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Biological sciences |
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Biological sciences Liori, Ourania Development and application of non-destructive biomarkers for biomonitoring endocrine disruption in pinnipeds |
topic_facet |
Biological sciences |
description |
Over the past years there has been an increased concern regarding widespread pollution of the environment with persistent organic pollutants (POPs) that biomagnify and bioaccumulate along the food chain. Marine mammals, especially seals being top predators of the marine food chain, are significantly exposed to biomagnified levels of POPs that bioaccumulate in the blubber which acts as a reservoir for these lipophilic compounds. POPs have been associated with a number of pathological changes in the seals, thus early detection of the adverse health effects resulting from pollutant exposure is vital, since exposure may cause irreversible damage to entire populations or ecosystems in the long term. Biomonitoring studies to investigate changes in fecundity of marine mammal populations due to exposure to POPs are needed. Biological indicators (biomarkers) that reflect the exposure levels or toxic effects of the contaminant load in wildlife populations can be used as early warning system for the reproduction and survival of the animals with non-destructive or minimal invasion. The aim of this study was to research and develop new and existing exposure and effect biomarkers for biomonitoring endocrine disruption in Ringed (Phoca hispida), Grey (Halichoerus grypus) and Harbour (Phoca vitulina) seals from different geographical areas using non-destructive/non-invasive sampling. Sex steroids, lactoferrin and blood chemistry parameters were investigated ill seal faecal and serum samples as potential biomarkers. Exposure level (PCBs, DDT, PBDEs) was determined using chromatographic and immunoassay techniques. Estrogens in the exposed populations showed a negative correlation with contaminant exposure and higher LTF, glucose and lipoprotein levels showed a positive correlation with contaminant exposure and negative correlation with sex steroids, thus they are proposed as biomarkers of endocrine disruption. This is the first study to quantify and measure LTF as well as sex steroids in seal faecal samples and to investigate ... |
format |
Thesis |
author |
Liori, Ourania |
author_facet |
Liori, Ourania |
author_sort |
Liori, Ourania |
title |
Development and application of non-destructive biomarkers for biomonitoring endocrine disruption in pinnipeds |
title_short |
Development and application of non-destructive biomarkers for biomonitoring endocrine disruption in pinnipeds |
title_full |
Development and application of non-destructive biomarkers for biomonitoring endocrine disruption in pinnipeds |
title_fullStr |
Development and application of non-destructive biomarkers for biomonitoring endocrine disruption in pinnipeds |
title_full_unstemmed |
Development and application of non-destructive biomarkers for biomonitoring endocrine disruption in pinnipeds |
title_sort |
development and application of non-destructive biomarkers for biomonitoring endocrine disruption in pinnipeds |
publisher |
Kingston University |
publishDate |
2006 |
url |
https://eprints.kingston.ac.uk/id/eprint/20378/ https://eprints.kingston.ac.uk/id/eprint/20378/1/Liori-O.pdf http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.433819 |
genre |
Phoca hispida Phoca vitulina |
genre_facet |
Phoca hispida Phoca vitulina |
op_relation |
https://eprints.kingston.ac.uk/id/eprint/20378/1/Liori-O.pdf Liori, Ourania (2006) Development and application of non-destructive biomarkers for biomonitoring endocrine disruption in pinnipeds. (PhD thesis), Kingston University, . |
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1779319117719797760 |